New voltammetric analysis of olanzapine in tablets and human urine samples using a modified carbon paste sensor electrode incorporating gold nanoparticles and glutamine in a micellar medium

Ahmed, Hytham M.; Mohamed, Mona A.; Salem, Waheed M.

doi:10.1039/c4ay02450h

Cited by 26 publications

(16 citation statements)

References 45 publications

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“…The presence of ascorbic acid (ASA) and uric acid (UA) were also explored upon the electrochemical oxidation of DPX ( Figure S6 ) because these two analytes coexist in many biological samples. 50 The electrochemical oxidation of 6.5 × 10 –6 M DPX in the presence of 6.5 × 10 –6 M ASA and UA were investigated using the Cs–Au/SPE via SWV, as shown in Figure S6 , which demonstrates that these are far resolved from the analytical peak of interest. The effect of many substances that can potentially interfere with the electroanalytical determination of DPX were also examined.…”

Section: Results and Discussionmentioning

confidence: 99%

Electrochemical Determination of the Serotonin Reuptake Inhibitor, Dapoxetine, Using Cesium–Gold Nanoparticles

et al. 2017

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Cesium–gold (Cs–Au) nanoparticles are shown to be analytically advantageous for the electroanalytical sensing of dapoxetine (DPX), a serotonin reuptake inhibitor used for the treatment of premature ejaculation. The Cs–Au nanoparticles are electrically wired and supported upon mass producible, economical screen-printed electrochemical sensing platforms and are characterized electrochemically (cyclic voltammetry and electrochemical impedance spectroscopy) and physiochemically (field emission scanning electron microscopy and energy dispersive X-ray analysis). The face-centered design was applied to optimize the significant experimental factors by using square wave voltammetry. The Cs–Au-based sensor is found to exhibit a large linear range (10–7 to 10–4 M) with a good analytical linearity with the limits of detection and quantification corresponding to 2.50 × 10–10 and 8.33 × 10–8 M, respectively. The developed sensor was successfully applied in the quantification of DPX in the presence of sildenafil, both of which are commonly found within combined dose tablet pharmaceutical formulations. The proposed DPX electrochemical Cs–Au-based sensor has the advantages of being single-shot and disposable and is shown to be successful in determining DPX in pharmaceutical formulations, human urine, and serum samples with acceptable recoveries.

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Section: Results and Discussionmentioning

confidence: 99%

Electrochemical Determination of the Serotonin Reuptake Inhibitor, Dapoxetine, Using Cesium–Gold Nanoparticles

et al. 2017

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“…There are also electroanalytical techniques such as potentiometry (Rouhani & Soleymanpour, 2019), amperometry with HPLC (Raggi et al, 2000), and voltammetry. Voltammetric methods are used for the determination of many antipsychotics including olanzapine (Karadurmus et al, 2019;Kul, 2019), the oxidative behavior of olanzapine with modified electrodes (Azab & Amany, 2019;Behzad et al, 2016;Ahmed et al, 2015;Shahrokhian et al, 2014;El Shal, 2013;Mashhadizadeh & Afshar, 2012;Merli et al, 2012), and the oxidative behavior of olanzapine on a glassy carbon electrode (Yılmaz et al, 2017;Biryol & Erk, 2013). However, an electroreduction study of olanzapine has not yet been reported.…”

Section: ___________________mentioning

confidence: 99%

Reduction Behavior of Olanzapine and Its Differential Pulse Voltammetric Determination in Human Urine and Pharmaceuticals

Yağmur

2020

Journal of Advanced Research in Natural and Applied Sciences

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The electrochemical reduction behavior of olanzapine was investigated by DPV (differential pulse voltammetry) and CV (cyclic voltammetry) techniques using a glassy carbon electrode. The measurements were carried out in different buffer solutions in a pH range from 0.50 to 12.05. The behavior of the peak potential and the peak current were examined by changing the pH, and a pH= 7.0 Britton-Robinson buffer solution was selected as the supporting electrolyte. To designate the electron and proton numbers that participated in the reaction, the changing peak potentials of olanzapine with increasing pH were investigated. The number of transferred electrons was found equal to the number of the hydrogen ions taking part in the electrode reaction. Equal electron and proton numbers were also supported with suggested reduction mechanism. For DPV analysis, the linear calibration curve of olanzapine was plotted between concentrations 2x10 -5 M and 1x10 -4 M at the pH= 7.0 Britton-Robinson buffer solution. The limit of detection (LOD) and the limit of quantification (LOQ) were found to be 1.88x10 -6 M and 6.29x10 -6 M, respectively. Lastly, the developed technique was applied to spiked urine and pharmaceutical preparations for recovery studies of olanzapine. A reaction mechanism related to the reduction of olanzapine was also proposed with this study.

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“…As a result, pH 5.0 was selected for this study. Ahmed et al demonstrated OLZ detection with a modified carbon paste sensor electrode incorporating gold nanoparticles and glutamine in a micellar medium (Ahmed et al 2015). They reported an LOD value of 3.58 × 10 -9 M in Britton-Robinson buffer (pH 7.0) and demonstrated the recovery of OLZ in urine samples.…”

Section: Introductionmentioning

confidence: 99%

A platinum black-modified microelectrode for in situ olanzapine detection in microliter volumes of undiluted serum

et al. 2020

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Olanzapine is a thienobenzodiazepine compound. It is one of the newer types of antipsychotic drugs used in the treatment of schizophrenia and other psychotic disorders. Several methods have been reported for analyzing olanzapine in its pure form or combined with other drugs and in biological fluids. These methods include high-performance liquid chromatography and liquid chromatography-tandem mass spectroscopy. Although many of the reported methods are accurate and sensitive, they require the use of sophisticated equipment, lack in situ analysis, and require expensive reagents. Moreover, several of these methods are cumbersome, require prolonged sample pretreatment, strict control of pH, and long reaction times. Here we present the development of a miniaturized electrochemical sensor that will enable minimally invasive, real-time, and in situ monitoring of olanzapine levels in microliter volumes of serum samples. For this purpose, we modified a microfabricated microelectrode with a platinum black film to increase the electrocatalytic activity of the microelectrode towards olanzapine oxidation; this improved the overall selectivity and sensitivity of the sensor. We observed in recorded voltammograms the anodic current dose response characteristics in microliter volumes of olanzapine-spiked serum samples that resulted in a limit of detection of 28.6 ± 1.3 nM and a sensitivity of 0.14 ± 0.02 µA/cm 2 nM. Importantly, the platinum black-modified microelectrode exhibited a limit of detection that is below the clinical threshold (65-130 nM). Further miniaturizing and integrating such sensors into point-of-care devices provide real-time monitoring of olanzapine blood levels; this will enable treatment teams to receive feedback and administer adjustable olanzapine therapy.

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New voltammetric analysis of olanzapine in tablets and human urine samples using a modified carbon paste sensor electrode incorporating gold nanoparticles and glutamine in a micellar medium

Cited by 26 publications

References 45 publications

Electrochemical Determination of the Serotonin Reuptake Inhibitor, Dapoxetine, Using Cesium–Gold Nanoparticles

Electrochemical Determination of the Serotonin Reuptake Inhibitor, Dapoxetine, Using Cesium–Gold Nanoparticles

Reduction Behavior of Olanzapine and Its Differential Pulse Voltammetric Determination in Human Urine and Pharmaceuticals

A platinum black-modified microelectrode for in situ olanzapine detection in microliter volumes of undiluted serum

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