New Wnt/β-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals

Qi, Jingjing; Yu, Yong A.; Öztürk, Özlem Akilli; Holland, Jane D.; Besser, Daniel; Fritzmann, Johannes; Wulf-Goldenberg, Annika; Eckert, K; Fichtner, Iduna; Birchmeier, Walter

doi:10.1136/gutjnl-2014-307900

Cited by 154 publications

(124 citation statements)

References 40 publications

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“…[54] Activated Wnt/β-catenin signaling promotes EMT, migration, and invasion of CRC cells by targeting miR-150, BOP1, CKS2, and NFL3 genes, which induced a mesenchymal-like morphological change and experimental metastasis of CRC cells. [55,56] High Wnt/β-catenin signaling is also critical in the maintenance of the stem cell niche, which leads to tumor progression and metastasis. [10] β-catenin accumulation in the nucleus or cytoplasm was identified as a poor prognosis marker and nuclear β-catenin was implicated as a potential target for cancer therapy.…”

Section: Discussionmentioning

confidence: 99%

Nuclear expression and/or reduced membranous expression of β-catenin correlate with poor prognosis in colorectal carcinoma

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Nuclear expression and/or reduced membranous expression of β-catenin correlate with poor prognosis in colorectal carcinoma

et al. 2016

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“…The cells with EMT are present certain anti-apoptotic activity and drug resistance [89]. The signaling pathways involved in EMT include TGF-β, Wnt, Hedgehog, Notch, ILK, and uPAR (urokinase-type plasminogen activator receptor) [90][91][92][93][94][95].…”

Section: Inhibition Of Tumor Metastasis By Dadsmentioning

confidence: 99%

The Progress of Diallyl Disulfide in Anti-Cancer

Lz¹,

Liao²,

Wang³

et al. 2017

Chemotherapy

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Considerable evidence in recent years suggests that garlic has anti-proliferative effects on various types of cancer. Garlic contains water-soluble and oil-soluble sulfur compounds. Oil-soluble compounds (OSCs), such as diallyl sulfide (DAS), diallyl disulfide (DADS), diallyl trisulfide (DATS) and ajoene are more effective than watersoluble compounds in protection against cancer. DADS, a major organosulfur compound derived from garlic, can reduce carcinogen-induced cancers in experimental animals and inhibit the proliferation of various types of cancer cells. The mechanisms of these action of DADS include activation of metabolic enzymes that detoxify carcinogens, suppression of the formation of DNA adducts, antioxidant effects, regulation of cell-cycle progression, induction of apoptosis, and inhibition of angiogenesis and metastasis. These topics are discussed in depth in this review.

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“…Colorectal cancer (CRC) remains one of the most common types of malignancy worldwide, and CRC-related mortality is largely caused by metastasis [1, 2]. Individuals with obesity are at a higher risk of certain types of malignancy, including CRC.…”

Section: Introductionmentioning

confidence: 99%

Cholesterol Enhances Colorectal Cancer Progression via ROS Elevation and MAPK Signaling Pathway Activation

Wang

Xuan

et al. 2017

Cell Physiol Biochem

180

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Background/Aims: Elevated serum cholesterol levels were linked to a higher risk of colorectal adenoma and colorectal cancer (CRC), while the effect of cholesterol on CRC metastasis has not been widely studied. Methods: CRC patients were enrolled to evaluate the association between low-density lipoprotein cholesterol (LDL) and CRC metastases, and LDL receptor (LDLR) level of the CRC tissue was assessed by immunohistochemistry. The effects of LDL on cell proliferation, migration and stemness were assessed in CRC cells in vitro, and the effects of high fat diet (HFD) on tumor growth and intestinal tumorigenicity were investigated in vivo. ROS assays, gene expression array analysis and western blot were used to explore the mechanisms of LDL in CRC progression. Results: The level of LDL was positively correlated with liver metastases, and a higher level of LDL receptor (LDLR) expression was associated with advanced N and M stages of CRC. In vitro, LDL promoted the migration and sphere formation of CRC cells and induced upregulated expression of “stemness” genes including Sox2, Oct4, Nanog and Bmi 1. High-fat diet (HFD) significantly enhanced tumor growth in vivo, and was associated with a shorter intestinal length in azoxymethane/dextran sodium sulfate (AOM/DSS)-treated mice. Furthermore, LDL significantly elevated reactive oxygen species (ROS) levels and Whole Human Genome Microarray found 87 differentially expressed genes between LDL-treated CRC cells and controls, which were largely clustered in the MAP kinase (MAPK) signaling pathway. Conclusions: LDL enhances intestinal inflammation and CRC progression via activation of ROS and signaling pathways including the MAPK pathway. Inflammation is strongly associated with cancer initiation, and the role of LDL in intestinal tumorigenicity should be further explored.

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New Wnt/β-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals

Cited by 154 publications

References 40 publications

Nuclear expression and/or reduced membranous expression of β-catenin correlate with poor prognosis in colorectal carcinoma

Nuclear expression and/or reduced membranous expression of β-catenin correlate with poor prognosis in colorectal carcinoma

The Progress of Diallyl Disulfide in Anti-Cancer

Cholesterol Enhances Colorectal Cancer Progression via ROS Elevation and MAPK Signaling Pathway Activation

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