Newborn calf intestinal absorption of immunoglobulins extracted from colostrum

Jf, Grongnet; Gronget-Pinchon, E; Levieux, Didier; Piot, Michel; Lareynie, J.

doi:10.1051/rnd:19860428

Cited by 12 publications

(20 citation statements)

References 34 publications

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“…No significant drop was recorded in the animals fed bovine colostrum, which indicate that the energy supply of such a diet was correct. The hematocrit (Table 4) was generally decreasing with time, which is in agreement with Grongnet (1986). Even if it is rare, rapid anaemia is always to be feared when newborn lambs receive bovine colostrum (Winter, 1983;Bernadina and Franken, 1985).…”

Section: Resultssupporting

confidence: 67%

“…On the other hand, destruction of indifferent germs is not needed for good intestinal transfer since, in the case of this experiment, no difference between native and heat treated colostrum was found as far as IgG plasma levels are concerned. If mixed and thawed colostrum or dried colostrum products (for instance semi-purified immunoglobulin) are characterized by low intestinal transfer (Grongnet et al 1986(Grongnet et al , 1995, the reason cannot be normal flora even if it is superabundant. Destruction or removal during processing of a specific absorption factor should be further taken into consideration.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Influence of bovine colostrum thermisation on immunoglobulin intestinal transfer in newborn lambs

Grongnet¹,

Santos²,

Piot³

et al. 1995

J. Anim. Feed Sci.

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Experiment was carried out to test the influence of mixed bovine colostrum thermisation on immunoglobulin intestinal absorption in newborn lambs. Thirty-three newborn lambs were alloted to three treatments: free maternal suckling or three meals of pooled bovine colostrum (30/kg BW), given 0.5, 3.5 and 6.5 h after birth or three meals of the same but previously heated bovine colostrum. Gentle thermal treatment (62°C for 1 min.) was used in order to preserve immunoglobulin biological activity. Immunoglobulin G levels determined in blood samples collected 3.5,6.5,9.5 and 12.5 h after birth were satisfactory but lower in animals receiving bovine colostrum. Thermisation resulted in decreased microbial contamination but did not affect Ig plasmatic levels. In the absence of pathogenic germs, heating colostrum is not necessary to enable an efficient intestinal transfer of immunoglobulin.

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Section: Resultssupporting

confidence: 67%

Section: Resultsmentioning

confidence: 99%

Influence of bovine colostrum thermisation on immunoglobulin intestinal transfer in newborn lambs

Grongnet¹,

Santos²,

Piot³

et al. 1995

J. Anim. Feed Sci.

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“…Balfour and Comline (1962) showed that Ig added to a saline solution were very poorly absorbed, this has been confirmed by Grongnet et al (1986). Therefore the key to efficient absorption of Ig appears to be in the colostrum itself.…”

Section: Diet Compositionmentioning

confidence: 61%

“…Therefore, it would be necessary to semi-purify the colostrum, however, this leads to the production of a colostrum for which the Ig are absorbed less efficiently. After this type of treatment, which may eliminate the factor thought to help absorption by Balfour and Comline (1962), the absorption of the Ig can be very low (Grongnet et al, 1986(Grongnet et al, , 1996. This was not the case for Nousiainen et al (1994) and more recently Grongnet et al (unpublished results) who showed that absorption and blood Ig levels were sufficient to give protection.…”

Section: The Role Of the Farmer And Industrymentioning

confidence: 99%

Acquisition of passive immunity in domestic ungulates

Grongnet¹,

Duvaux-Ponter

1998

J. Anim. Feed Sci.

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The ungulates possess an epteriochondrial placenta, which separates the maternal and foetal blood systems and thus reduces the permeability of the placenta to small molecules. Thus, in these species, the colostral imminoglobulins are the main source of protection factors which aid survival in the first days of life. This review deals with several aspects of passive immunity in ungulate neonates: the type and the origin of colostral immunoglobulins and factors which influence their production in the mother and their absorption form the gastrointestinal tract of the neonate.Recommendations for farmes to enhance natural postnatal immunity and recent technological advances in the production of immunoglobulin preparations are discussed.

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“…Another option would consist in the removal of most of the fat and protein of the colostrum. Extraction of immunoglobulins from colostrum, followed by their concentration may be used but according to Grongnet et al [20], such extracted immunoglobulins are poorly absorbed by the intestine of the newborn calf. Some food additives which might help reestablish the absorption capacity have been tested by the same authors (Grongnet et al [19]).…”

Section: Introductionmentioning

confidence: 99%

Immunoglobulin G absorption from pooled maternal colostrum, commercial powder and freeze-dried colostrum by newborn calves

Wereme

Strabel

Grongnet³

et al. 2001

Anim. Res.

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-For many reasons, a lot of newborn ruminants have no access to their mother's colostrum and are therefore not protected against neonatal diseases. Many commercial colostra-replacers are now available, but their ability to pass the intestinal wall is not well established. Therefore, two experiments were carried out to test the value of two maternal colostra, freeze-dried immunoglobulins extracted from the colostra of Holstein cows, and a commercial dried colostrum powder, as colostrum substitute. Fifty-seven Holstein calves were fed the same immunoglobulin concentration exactly 1, 7 and 15 h after birth. They were divided into four groups A, B, C and D with respectively 16, 16, 13 and 12 animals. Total immunoglobulin G concentrations were the highest at 24 h in all groups but the freeze-dried colostrum was best absorbed. The IgG of the whole and the freeze-dried colostra were well absorbed by the calves: the second meal increased the IgG of the calves over 10 g . L -1 , usually considered as the minimum level of protection of the newborn. The commercial dried colostrum powder was not well absorbed and showed low immunoglobulin levels at 24 h postpartum. It was concluded that even when colostra are given in the same concentrations to calves, the absorption of immunoglobulins differ, because of the complexity and the probable sensitivity and alteration of colostrum components during technological treatments.birth / calf / colostrum / absorption / immunoglobulin G Résumé -Absorption des immunoglobines G chez le veau nouveau-né. Pour diverses raisons, de nombreux ruminants nouveau-nés n'ont pas accès au colostrum de leur mère pour se protéger contre les infections néonatales. Des substituts du colostrum sont actuellement disponibles sur le marché mais leur absorption intestinale par le nouveau-né n'est pas clairement établie. Deux A. N'Diaye Wereme et al. 316

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Newborn calf intestinal absorption of immunoglobulins extracted from colostrum

Abstract: Introduction.

Cited by 12 publications

References 34 publications

Influence of bovine colostrum thermisation on immunoglobulin intestinal transfer in newborn lambs

Influence of bovine colostrum thermisation on immunoglobulin intestinal transfer in newborn lambs

Acquisition of passive immunity in domestic ungulates

Immunoglobulin G absorption from pooled maternal colostrum, commercial powder and freeze-dried colostrum by newborn calves

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