Newborn Metabolic Profile Associated with Hyperbilirubinemia With and Without Kernicterus

McCarthy, Molly; Oltman, Scott P.; Baer, Rebecca J.; Ryckman, Kelli K.; Rogers, Elizabeth E.; Steurer-Muller, Martina; Witte, John S.; Jelliffe‐Pawlowski, Laura L.

doi:10.1111/cts.12590

Cited by 13 publications

(6 citation statements)

References 29 publications

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“…Previous studies have shown that elevated valine, leucine, lysine, isoleucine and alanine levels reflected abnormal amino acid metabolism in patients with neonatal jaundice [10] , and revealed transient high serum methionine levels and hypermethioninemia helped distinguish the various causes of obstructive jaundice in these infants [20] . Additionally, altered serum phenylalanine, ornithine, isoleucine and leucine metabolism in neonates is closely associated with the presence of combined bilirubin encephalopathy in neonates with hyperbilirubinemia [21] , which is consistent with the results of our study. Whether the results of our gut metabolomic may help distinguish neonates with hyperbilirubinemia from HC and as metabolic markers for NJ requires further investigation.…”

Section: Discussionsupporting

confidence: 92%

Machine learning approach identifies meconium metabolites as potential biomarkers of neonatal hyperbilirubinemia

Zeng

Wang

Zhang

et al. 2022

Computational and Structural Biotechnology Journal

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Section: Discussionsupporting

confidence: 92%

Machine learning approach identifies meconium metabolites as potential biomarkers of neonatal hyperbilirubinemia

Zeng

Wang

Zhang

et al. 2022

Computational and Structural Biotechnology Journal

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“…The possible link between this disease and bilirubin concentrations is unknown. However, for the other gene, KANK1, there may be a stronger relationship, given that deletions in this gene have been associated with cerebral palsy and alterations in neurodevelopment [74] and it is known that, in the case of extreme hyperbilirubinemia in the newborn neurological sequelae can occur, including the Kernicterus Spectrum Disorders [30,75]. However, our data on this level of statistical significance only provide suggestive results for later replication.…”

Section: Discussionmentioning

confidence: 59%

“…Initially, the focus was between the association of high bilirubin concentrations and jaundice in children and other related syndromes (Gilbert, etc.) as well as liver damage in adults [28,29,30,75]. However, even in Gilbert’s syndrome [26], associated with SNPs in the UGT1A1 gene and a mild hyperbilirubinemia, a lower incidence of cardiovascular diseases has been reported [76].…”

Section: Discussionmentioning

confidence: 99%

Genome-Wide Association Study (GWAS) on Bilirubin Concentrations in Subjects with Metabolic Syndrome: Sex-Specific GWAS Analysis and Gene-Diet Interactions in a Mediterranean Population

et al. 2019

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Although, for decades, increased serum bilirubin concentrations were considered a threatening sign of underlying liver disease and had been associated with neonatal jaundice, data from recent years show that bilirubin is a powerful antioxidant and suggest that slightly increased serum bilirubin concentrations are protective against oxidative stress-related diseases, such as cardiovascular diseases. Therefore, a better understanding of the gene-diet interactions in determining serum bilirubin concentrations is needed. None of the previous genome-wide association studies (GWAS) on bilirubin concentrations has been stratified by sex. Therefore, considering the increasing interest in incorporating the gender perspective into nutritional genomics, our main aim was to carry out a GWAS on total serum bilirubin concentrations in a Mediterranean population with metabolic syndrome, stratified by sex. Our secondary aim was to explore, as a pilot study, the presence of gene-diet interactions at the GWAS level. We included 430 participants (188 men and 242 women, aged 55–75 years, and with metabolic syndrome) in the PREDIMED Plus-Valencia study. Global and sex-specific GWAS were undertaken to analyze associations and gene-diet interaction on total serum bilirubin. Adherence (low and high) to the Mediterranean diet (MedDiet) was analyzed as the dietary modulator. In the GWAS, we detected more than 55 SNPs associated with serum bilirubin at p < 5 × 10−8 (GWAS level). The top-ranked were four SNPs (rs4148325 (p = 9.25 × 10−24), rs4148324 (p = 9.48 × 10−24), rs6742078 (p = 1.29 × 10−23), rs887829 (p = 1.39 × 10−23), and the rs4148324 (p = 9.48 × 10−24)) in the UGT1A1 (UDP glucuronosyltransferase family 1 member A1) gene, which replicated previous findings revealing the UGT1A1 as the major locus. In the sex-specific GWAS, the top-ranked SNPs at the GWAS level were similar in men and women (the lead SNP was the rs4148324-UGT1A1 in both men (p = 4.77 × 10−11) and women (p = 2.15 × 10−14), which shows homogeneous genetic results for the major locus. There was more sex-specific heterogeneity for other minor genes associated at the suggestive level of GWAS significance (p < 1 × 10−5). We did not detect any gene-MedDiet interaction at p < 1 × 10−5 for the major genetic locus, but we detected some gene-MedDiet interactions with other genes at p < 1 × 10−5, and even at the GWAS level for the IL17B gene (p = 3.14 × 10−8). These interaction results, however, should be interpreted with caution due to our small sample size. In conclusion, our study provides new data, with a gender perspective, on genes associated with total serum bilirubin concentrations in men and women, and suggests possible additional modulations by adherence to MedDiet.

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“…27 Neonatal metabolism is associated with hypertrophy of blood bilirubin, thyroidstimulating hormone (TSH) and C-18:2 decreased jaundice associated with levels of TSH, T4, and G6PD. 28,29 Residential zones are associated with hypothyroidism. Home locations affect pregnant women using iodine salt and getting enough iodine from food.…”

Section: Discussionmentioning

confidence: 99%

Factors affecting to neonatal thyroid hormone deficiency in the era of the COVID-19 pandemic, Akat Amnuai district, Sakon Nakhon Province

Suttawanit¹,

Srisamai²

2023

Int J Reprod Contracept Obstet Gynecol

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Background: In the spread of COVID-19 Less exposure to iodine affects the health of the pregnant woman and fetus, causing miscarriages and premature births. low birth weight, anemia and hypothyroidism in newborns. Changes in levels of thyroid-stimulating hormone besides genetics, and many environmental factors can also affect thyroid function. This research aims to study the impact of environmental factors on thyroid-stimulating hormone in newborns. Methods: The sample consisted of 134 postpartum women randomly selected by simple method from 807 postpartum women in 2020-2022. The data were collected between June-July 2022 by interviewing social, environment, and household economy. Lifestyle, Iodine salt intake, drugs, iodine supplements and quality antenatal care correlation with Thyroid-stimulating hormone were determined by multiple logistic regression, adjusted odd ratio (ORadj), and 95%Confidence Interval (95% CI) were presented. Results: The results revealed that 67.7% were pregnant aged 20-34 years, 50.7% took iodized salt before pregnancy, 67.2% consumed during pregnancy, 45.5% received salt during antenatal care, 30.6% took folate(B9) before pregnancy,53.0%took antenatal care qualitatively and took iodine supplementation (57.5% daily intake, 29.9% intake 4-6 days/week, 11.9% intake 2-3 days/week). Most of them consume high iodine foods not variety and not frequent enough. High iodine supplements/diet intake, household income, COVID-19 infection, and antenatal care qualitatively were not significant. The significant correlation factor was not eating iodized salt, low education level and residing in the sub-district administrative organization. The results of the correlation analysis using Backward elimination showed that positively correlated with pregnant women whose husbands drink alcohol were hypothyroidism 0.3 times (95%CI=0.10-0.66), husbands smoking 0.4 times (95% CI=0.20-0.94, and pre-pregnancy malnutrition were 2.6 times (95%CI=1.17-5.74). Conclusions: The findings iodine affects to health of pregnant women and fetuses, Therefore, a more rigorous monitoring system for Iodized salt should be designed to encourage a higher rate of pregnant women to take iodine supplementation daily.

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Newborn Metabolic Profile Associated with Hyperbilirubinemia With and Without Kernicterus

Cited by 13 publications

References 29 publications

Machine learning approach identifies meconium metabolites as potential biomarkers of neonatal hyperbilirubinemia

Machine learning approach identifies meconium metabolites as potential biomarkers of neonatal hyperbilirubinemia

Genome-Wide Association Study (GWAS) on Bilirubin Concentrations in Subjects with Metabolic Syndrome: Sex-Specific GWAS Analysis and Gene-Diet Interactions in a Mediterranean Population

Factors affecting to neonatal thyroid hormone deficiency in the era of the COVID-19 pandemic, Akat Amnuai district, Sakon Nakhon Province

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