Newborns from women infected with COVID-19: somatic and metabolic status

Abstract

To date, there are limited data regarding manifestations of new coronavirus infection in infants born of SARS-CoV-2 infected mothers, so the aim of this study is to investigate somatic and metabolic status of newborn infants born to mothers diagnosed with COVID-19. The investigation was carried out on the bases of Laboratory Diagnostic Department of Samara Regional Clinical Hospital named after V.D. Seredavin and the Department of Fundamental and Clinical Biochemistry with Laboratory Diagnostics of Samara State Medical University. Under observation were 85 newborns, including 35 born of healthy mothers and 50 born of COVID-19 mothers.The somatic status of all newborns was assessed using the Apgar scale at the 1st and 5th minutes after birth. Also all newborns had general and biochemical blood tests and newborns from mothers with COVID-19 were tested for the presence of SARS-CoV-2 RNA in oral and nasopharyngeal swabs. Thus, the study of somatic status revealed that of 50 neonates from women infected with COVID-19, only 18% were practically healthy, the rest had signs of prematurity, hypotrophy, perinatal CNS damage, diabetic fetopathy, pulmonary atelectasis, delayed intrauterine development, asphyxia. The metabolic state is characterised by decreased haemoglobin and platelets, increased concentration of total protein, including C-reactive protein, high transaminase activity, decreased sodium and chloride content. These parameters of general and biochemical blood tests can be considered as indicators for the evaluation of the condition of newborns from mothers with COVID-19.

Perinatal and neonatal outcomes with coronavirus disease 2019 (COVID-19) in the Khabarovsk territory

“…По мере накопления статистических данных число инфицированных новорожденных возросло с 3 до 12% и даже до 30% [9][10][11]; мы не можем быть уверены в безопасности применения тех или иных методик; остается открытым вопрос о вероятности вертикальной передачи вируса и др. [11][12][13][14].…”

“…Отсутствие достоверных знаний о путях передачи COVID-19 при беременности, изменчивость вируса, сложности профилактики -все это, несомненно, изменило тактику ведения беременности и родов с применением многочисленных мер по обеспечению инфекционной безопасности беременных, а также осуществляющих уход и медицинскую помощь, и новорожденных. При этом происходят накопление данных, анализ имеющихся фактов и еще предстоят обобщение, стандартизация и создание рекомендаций, основанных на доказательной базе [11][12][13][14][15][16][17][18].…”

Global research on emerging trends of obstetrics during the COVID-19 pandemic: A bibliometric analysis

“…[12] Infants born to COVID-19-infected pregnant women are more likely to be infected with COVID-19 and have a higher incidence of adverse outcomes, including undernutrition, perinatal central nervous system damage, diabetic fetal disease, pulmonary atelectasis, delayed intrauterine growth, asphyxia, and other diseases and signs and symptoms. [12][13][14] The number of articles examining COVID-19 has continued to rise since the outbreak of the coronavirus epidemic, and the impact of COVID-19 on maternal and neonatal outcomes has been substantial, resulting in a rapid growth of published literature in the field of COVID-19 and obstetrics. Therefore, we anticipate a growing focus and research interest in the intersection of COVID-19 and obstetrics.…”