Newbouldiaquinone and Newbouldiamide: A New Naphthoquinone—Anthraquinone Coupled Pigment and a New Ceramide from Newbouldia laevis.

Eyong, Kenneth O.; Krohn, Karsten; Hussain, Hidayat; Folefoc, Gabriel N.; Nkengfack, Augustin Ephram; Schulz, Barbara; Hu, Qunxiu

doi:10.1002/chin.200546174

Cited by 9 publications

(11 citation statements)

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“…In addition, the antioxidant, antiulcerogenic, arginase inhibitory, hepatoprotective and antibacterial properties of the aqueous leaf extract have been reported [18,19,20,21]. Previous studies have shown that among compounds isolated from the Bignoniaceae, naphthoquinones in general and furanonaphthoquinones in particular, exhibit a broad spectrum of biological activities [22][23][24][25]26].…”

Section: Despitementioning

confidence: 99%

Anti-Acetylcholinesterase Compounds Isolated from the Leaves of Kigelia africana (LAM) Benth (Bignoniaceae)

Falode

Crown

Famuyiwa

et al. 2019

EJMP

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Acetylcholinesterase (AChE) is an enzyme that is involved in the breakdown of some neurotransmitters. Its inhibition is one of the treatment strategies employed in the management Alzheimer diseases. Flavonoids isolated from the leaves of Kigelia africana were investigated for their comparative AChE inhibition. The extract of the leaves was subjected to vacuum liquid chromatography (VLC) to obtain four fractions using n-hexane (n-hex, 100%), n-hexane/dichloromethane (hex/DCM, 1:1), dichloromethane/ethyl acetate (DCM/EtOAc, 1:1) and ethyl acetate/methanol (EtOAc/MeOH, 1:1). The four fractions were subjected to AChE inhibitory study with DCM/EtOAc (1:1) fraction showing the highest inhibitory activity. Three flavonoids were isolated from this fraction and their structures were elucidated and characterised using 1D- and 2D-nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) techniques. Their spectroscopic data compared well with literature. The compounds demonstrated considerable inhibition of AChE activity with luteolin (1), rutin (2) and quercetin (3) that showed IC50 of 945.0, 282.1, 254.8 μg/ml respectively as against the IC50 of 38.93 μg/ml for rivastigmine, a well-known cholinesterase agent. Compound 3 showed 17.89 ± 0.57 and 7.70 ± 0.64 μ/l/mg protein at 200 and 400 μg/ml respectively, for AChE activity as against 10.37 ± 0.99 and 6.24 ± 1.24 μ/l/mg protein showed by rivastigmine at 200 and 400 μg/ml respectively. This study showed that the phytochemical responsible for the AChE inhibition in the crude extract as reported by Falode et al., 2017 resided in the DCM/EtOAc (1:1) fraction. The structural-activity relationship of the flavonoids revolves around substitution in position 3 of the compounds.

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Section: Despitementioning

confidence: 99%

Anti-Acetylcholinesterase Compounds Isolated from the Leaves of Kigelia africana (LAM) Benth (Bignoniaceae)

Falode

Crown

Famuyiwa

et al. 2019

EJMP

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“…They are widely accepted as an important and promising alternative drug delivery system because they are endowed with several advantages of different traditional drug carrier systems, while avoiding some of their disadvantages. 5 –7…”

Section: Introductionmentioning

confidence: 99%

Development, in vitro and in vivo evaluations of novel lipid drug delivery system of Newbouldia laevis (P. Beauv.)

et al. 2016

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Newbouldia laevis (P. Beauv.) is a tropical rainforest plant used in traditional folk medicine for the treatment of malaria, cough, joint pains, stomach ache, oedema and inflammation. The main thrust of this research work was to study the analgesic/anti-nociceptive properties of N. laevis-loaded solid lipid microdispersions. N. laevis leaves were extracted using ethanol, and the extract was formulated into solid lipid microdispersions using lipid matrix comprising a rational blend of Precirol® ATO 5 and Softisan® 154. Characterization of the solid lipid microdispersions include determination of morphology, particle size, pH, thermal property, encapsulation efficiency percentage and analgesic/anti-nociceptive property. The results obtained showed that the particles were spherical with sizes ranging from 40 µm to 125 µm. The solid lipid microdispersions maintained a stable pH within the acidic region of 5–6 with insignificant variations (p > 0.05) over a period of 90 days. Thermal analysis showed that N. laevis was entrapped in the lipid matrix used for the formulations. Solid lipid microdispersions recorded a maximum encapsulation efficiency up to 88.1%. N. laevis-loaded solid lipid microdispersions also produced good analgesic/anti-nociceptive property comparable with the standard diclofenac potassium. N. laevis-loaded solid lipid microdispersions showed good analgesic/anti-nociceptive effect and could be used in the treatment and management of pain.

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“…It is a medium sized angiosperm which grows to a height of about 7 to 8 (up to 15 m), more, usually a shrub of 2 to 3 m, many-stemmed forming dumps of gnarled branches (Arbonnier, 2004). N. laevis is widely used in African folk medicine for the treatment of malaria and fever, stomach ache, coughs, sexually transmitted disease, tooth ache, breast cancer, and constipation (Iwu, 2000;Gorman et al, 2003;Eyong et al, 2005). In south eastern and part of the Midwestern Nigeria, the plant is used for the treatment of septic wounds, the young leaves are crushed in little places in water and the extract is put into the eye to cure eye inflammation and redness, it is also administered to stop vaginal bleeding in threatened abortion (Gill, 1992;Kargbo, 1982).…”

Section: Introductionmentioning

confidence: 99%

Improved gastric lesion of ulcerogenic mice treated with bark extracts and fractions of Newbouldia laevis

Umeokoli¹,

Ekeh²,

Eze³

et al. 2015

Afr. J. Pharm. Pharmacol.

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Newbouldia laevis is used in Nigerian traditional medicine for the treatment of various diseases including gastric ulcer. The present study was undertaken to validate the anti-ulcer potential of N. laevis stem bark. The plant was extracted using ethanol and fractionated using N-hexane, ethyl acetate and water. Phytochemical evaluation of the extract and fractions of the plant was done using standard procedures. The anti-ulcer property of the crude extract and fractions of the plant was investigated against ethanol induced gastric ulcer in white albino rats using Cimetidine (100 mg/kg) as the standard control. Primary screening of the crude ethanol extract of N. laevis stem bark against Salmonella typhi, Staphylococcus aureus, Streptococcus pneumoniae, Bacillus subtilis, Klebsiella pneumoniae, and Pseudomonas aeruginosa was determined using the agar well diffusion method. Also, the minimum inhibitory concentrations (MICs) of the extract on the test organisms were determined using the agar dilution method. The result showed that the crude extract and fractions of the plant significantly (P < 0.001) produced protection in the ethanol-induced ulceration and reduced the ulcer index when compared to the control . Preliminary phytochemical screening of the crude extract and fractions revealed the presence of steroid, glycosides, flavonoids, saponins terpenoids, and tannins while alkaloids were absent. At the concentrations analyzed (15.625 to 500 mg/ml), the inhibition zone diameters (IZDs) produced by the crude ethanol extract against test isolates ranged from 0 to 14 mm. Also, the MICs of the plant extracts on test organisms ranged from 6.25 to 25 mg/ml. The extract recorded best antibacterial activity against K. pneumoniae followed by S. typhi. In conclusion, the present study provided preliminary data that the extract and fractions of N. laevis possesses significant anti-ulcer activity in animal models. The gastric anti-secretory and acid neutralizing effect of the plant plus its antibacterial activity reveals the anti-ulcer potential of the plant.

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Newbouldiaquinone and Newbouldiamide: A New Naphthoquinone—Anthraquinone Coupled Pigment and a New Ceramide from Newbouldia laevis.

Abstract: For Abstract see ChemInform Abstract in Full Text.

Cited by 9 publications

References 1 publication

Anti-Acetylcholinesterase Compounds Isolated from the Leaves of Kigelia africana (LAM) Benth (Bignoniaceae)

Anti-Acetylcholinesterase Compounds Isolated from the Leaves of Kigelia africana (LAM) Benth (Bignoniaceae)

Development, in vitro and in vivo evaluations of novel lipid drug delivery system of Newbouldia laevis (P. Beauv.)

Improved gastric lesion of ulcerogenic mice treated with bark extracts and fractions of Newbouldia laevis

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