2021
DOI: 10.3390/genes12040495
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Newcastle Disease Virus Induced Pathologies Severely Affect the Exocrine and Endocrine Functions of the Pancreas in Chickens

Abstract: Newcastle disease virus (NDV) causes a highly contagious and devastating disease in poultry. ND causes heavy economic losses to the global poultry industry by decreasing the growth rate, decrease in egg production high morbidity and mortality. Although significant advances have been made in the vaccine development, outbreaks are reported in vaccinated birds. In this study, we report the damage caused by NDV infection in the pancreatic tissues of vaccinated and specific-pathogen-free chickens. The histopatholog… Show more

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Cited by 9 publications
(10 citation statements)
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“…Viral infection is among the causes of pancreatitis and the elevation of AMYL activity in the blood [ 95 ]; this was reviewed in [ 96 ]. In contrast, damage to the exocrine portion of the pancreas caused by Newcastle disease viral infection decreased the activity of AMYL and its mRNA expression in the chicken pancreas [ 44 ]. Serum and saliva AMYL activities were higher in diseased dogs than in healthy dogs [ 97 ], and both high and low AMYL activities were observed in humans with chronic kidney disease [ 98 ].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Viral infection is among the causes of pancreatitis and the elevation of AMYL activity in the blood [ 95 ]; this was reviewed in [ 96 ]. In contrast, damage to the exocrine portion of the pancreas caused by Newcastle disease viral infection decreased the activity of AMYL and its mRNA expression in the chicken pancreas [ 44 ]. Serum and saliva AMYL activities were higher in diseased dogs than in healthy dogs [ 97 ], and both high and low AMYL activities were observed in humans with chronic kidney disease [ 98 ].…”
Section: Discussionmentioning
confidence: 99%
“…The details of statistical analyses of blood analytes, including normality testing, and transformation and back-transformation of the means and standard errors, are often unclear in published reports. For instance, no indication of the normality testing prior to a multi-way analysis of variance for blood analytes was reported in mink [ 38 , 39 , 40 , 41 ], dogs [ 42 ], cats [ 43 ], and chickens [ 44 ]. Blood analytes have also been compared between two [ 33 , 45 , 46 , 47 , 48 ] or more groups [ 49 , 50 , 51 , 52 , 53 , 54 , 55 ] with a t-test without prior normality testing.…”
Section: Introductionmentioning
confidence: 99%
“…Most of the research into NDV is done as viral challenge models in chickens or in ovo using SPF embryonated chicken eggs, but the strain of chicken and the precise definition of SPF are not often disclosed [444,[478][479][480][481][482][483]. The most commonly reported strain of chicken used is the White Leghorn, along with others such as White Rock and Isa Brown layers [120,447,[484][485][486].…”
Section: Newcastle Diseasementioning
confidence: 99%
“…The virus strain and challenge dose of NDV is usually given and is often the experimental variable, but there is not a standard strain and dose that is used as a model of ND [478,485]. A common vaccine strain used in studies is the LaSota strain [430,450,452,480,483,488,489]. Other host species are also used, including Japanese quail (Coturnix coturnix japonica) and pigeons (Columba livia) [480,485].…”
Section: Newcastle Diseasementioning
confidence: 99%
“…NDV induces extensive tissue damage in the testes, brain and liver, and affects the exocrine and endocrine functions of the pancreas. 1 , 21 , 22 , 23 , 24 …”
Section: Introductionmentioning
confidence: 99%