Newcastle Disease Virus Vectored Bivalent Vaccine against Virulent Infectious Bursal Disease and Newcastle Disease of Chickens

Dey, Sohini; Chellappa, Madhan Mohan; Pathak, D. C.; Gaikwad, Satish S.; Yadav, Kalpana; Ramakrishnan, Saravanan; Vakharia, Vikram N.

doi:10.3390/vaccines5040031

Cited by 21 publications

(24 citation statements)

References 36 publications

(42 reference statements)

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“…Following vaccination, the recombinant NDV generated an effective humoral immune response against ND and ARV infection. Protection against NDV is primarily by the humoral immune response, as is evidenced by several earlier vaccine studies [17,40,41,42]. Moreover, the anti-σC antibody response generated with the recombinant virus was comparable with the ARV inactivated vaccine.…”

Section: Discussionmentioning

confidence: 51%

“…Viral vectored vaccines could be an alternate approach to control ARV infection. A number of attenuated poultry vaccine viruses, such as Newcastle disease virus (NDV) [14,15,16,17], fowl pox virus (FPV) [18,19,20], adenovirus [21], herpesvirus of turkeys (HVT) [22,23], infectious laryngotracheitis virus (ILTV) [24,25] and Marek’s disease virus (MDV) [26,27,28] have been genetically modified in order to use them as vaccine vectors for developing combinations of live attenuated vaccines for controlling the diseases of poultry. Among these viruses, NDV is an attractive vaccine vector for both human and animal diseases.…”

Section: Introductionmentioning

confidence: 99%

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Recombinant Newcastle Disease Virus (NDV) Expressing Sigma C Protein of Avian Reovirus (ARV) Protects against Both ARV and NDV in Chickens

et al. 2019

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Newcastle disease (ND) and avian reovirus (ARV) infections are a serious threat to the poultry industry, which causes heavy economic losses. The mesogenic NDV strain R2B is commonly used as a booster vaccine in many Asian countries to control the disease. In this seminal work, a recombinant NDV strain R2B expressing the sigma C (σC) gene of ARV (rNDV-R2B-σC) was generated by reverse genetics, characterized in vitro and tested as a bivalent vaccine candidate in chickens. The recombinant rNDV-R2B-σC virus was attenuated as compared to the parent rNDV-R2B virus as revealed by standard pathogenicity assays. The generated vaccine candidate, rNDV-R2B-σC, could induce both humoral and cell mediated immune responses in birds and gave complete protection against virulent NDV and ARV challenges. Post-challenge virus shedding analysis revealed a drastic reduction in NDV shed, as compared to unvaccinated birds.

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Section: Discussionmentioning

confidence: 51%

Section: Introductionmentioning

confidence: 99%

Recombinant Newcastle Disease Virus (NDV) Expressing Sigma C Protein of Avian Reovirus (ARV) Protects against Both ARV and NDV in Chickens

et al. 2019

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“…Live and inactivated vaccines are widely available for the control of IBD. However, these vaccines have the potential risks of incomplete inactivation and reversion to virulence [ 30 ]. A recent study reported that the homologous recombination between the nVarIBDV and IBDV intermediate vaccine strain increased the pathogenicity of nVarIBDV [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Development of a Viral-Like Particle Candidate Vaccine Against Novel Variant Infectious Bursal Disease Virus

et al. 2021

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Infectious bursal disease (IBD), an immunosuppressive disease of young chickens, is caused by infectious bursal disease virus (IBDV). Novel variant IBDV (nVarIBDV), a virus that can evade immune protection against very virulent IBDV (vvIBDV), is becoming a threat to the poultry industry. Therefore, nVarIBDV-specific vaccine is much needed for nVarIBDV control. In this study, the VP2 protein of SHG19 (a representative strain of nVarIBDV) was successfully expressed using an Escherichia coli expression system and further purified via ammonium sulfate precipitation and size-exclusion chromatography. The purified protein SHG19-VP2-466 could self-assemble into 25-nm virus-like particle (VLP). Subsequently, the immunogenicity and protective effect of the SHG19-VLP vaccine were evaluated using animal experiments, which indicated that the SHG19-VLP vaccine elicited neutralization antibodies and provided 100% protection against the nVarIBDV. Furthermore, the protective efficacy of the SHG19-VLP vaccine against the vvIBDV was evaluated. Although the SHG19-VLP vaccine induced a comparatively lower vvIBDV-specific neutralization antibody titer, it provided good protection against the lethal vvIBDV. In summary, the SHG19-VLP candidate vaccine could provide complete immune protection against the homologous nVarIBDV as well as the heterologous vvIBDV. This study is of significance to the comprehensive prevention and control of the recent atypical IBD epidemic.

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“…The role of cell-mediated immunity following IBDV infection is well established31,32 with the localization of bursal mRNA transcription of the pro-inflammatory cytokines IL-1β, IL-6, CXCLi2 and IFN-γ together with downregulation of transcription growth factor-β4. In vivo challenge with vvIBDV UK661 strain upregulated the transcription levels of types I, II and III IFNs as well as IL-18, IL-4 and IL-13 cytokines 33…”

Section: Immune Response Towards Ibdv Infectionmentioning

confidence: 99%

<p>Infectious bursal disease virus in chickens: prevalence, impact, and management strategies</p>

Dey¹,

Pathak²,

Narayan³

et al. 2019

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Infectious bursal disease (IBD), also known as Gumboro disease, is a highly contagious, immunosuppressive disease of young chickens. Although first observed about 60 years ago, to date, the disease is responsible for major economic losses in the poultry industry worldwide. IBD virus (IBDV), a double-stranded RNA virus, exists as two serotypes with only serotype 1 causing the disease in young chickens. The virus infects the bursa of Fabricius of particularly the actively dividing and differentiating lymphocytes of the B-cells lineage of immature chickens, resulting in morbidity, mortality, and immunosuppression. Immunosuppression enhances the susceptibility of chickens to other infections and interferes with vaccination against other diseases. Immunization is the most important measure to control IBD; however, rampant usage of live vaccines has resulted in the evolution of new strains. Although the immunosuppression caused by IBDV is more directed toward the B lymphocytes, the protective immunity in birds depends on inducement of both humoral and cell-mediated immune responses. The interference with the inactivated vaccine induced maternally derived antibodies in young chicks has become a hurdle in controlling the disease, thus necessitating the development of newer vaccines with improved efficacy. The present review illustrates the overall dynamics of the virus and the disease, and the recent developments in the field of virus diagnosis and vaccine research.

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Newcastle Disease Virus Vectored Bivalent Vaccine against Virulent Infectious Bursal Disease and Newcastle Disease of Chickens

Cited by 21 publications

References 36 publications

Recombinant Newcastle Disease Virus (NDV) Expressing Sigma C Protein of Avian Reovirus (ARV) Protects against Both ARV and NDV in Chickens

Recombinant Newcastle Disease Virus (NDV) Expressing Sigma C Protein of Avian Reovirus (ARV) Protects against Both ARV and NDV in Chickens

Development of a Viral-Like Particle Candidate Vaccine Against Novel Variant Infectious Bursal Disease Virus

<p>Infectious bursal disease virus in chickens: prevalence, impact, and management strategies</p>

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