Newer concepts of atopic dermatitis

Hanifin, John M.

doi:10.1001/archderm.113.5.663

Cited by 97 publications

(31 citation statements)

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“…Clinically, these patients are susceptible to develop disseminated viral infections with herpes simplex and vaccinia viruses (5). This in vivo observation correlates with in vitro experiments showing that the majority of AD patients are unable to generate normal T8+ cytotoxic T cell activity after allogeneic stimulation (6).…”

Section: Introductionsupporting

confidence: 66%

Impairment of the autologous mixed lymphocyte reaction in atopic dermatitis.

Leung¹,

Saryan²,

Frankel³

et al. 1983

J. Clin. Invest.

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A B S T R A C T The T cell proliferative response to autologous non-T cells is termed the autologous mixed lymphocyte reaction (AMLR). Recent studies have suggested that the AMLR represents an inducer circuit for the activation of T8+ suppressor/cytotoxic effector cells. Since atopic dermatitis (AD) patients are deficient in T8+ cytolytic T cell function, we investigated the AMLR in AD. When sheep erythrocytes were used to separate T cells from non-T cells, the AMLR was found to be significantly decreased (P < 0.001) in AD patients (n = 11; Acpm = 1,550±393) when compared with normal control subjects (n = 13; Acpm = 25,819±4,609). To exclude the possibility that these results were an artifact of the sheep erythrocyte separation, T cells were also separated on a fluorescenceactivated cell sorter after treatment of peripheral blood lymphocytes with the OKT3 monoclonal antibody. AD T cells separated by the latter method were also found to have a significantly reduced AMLR response when compared with similarly treated normal T cells. Co-culture studies using cells from AD patients and their HLA identical siblings indicated that the defect resided at the responder T cell level rather than at the stimulator non-T cell level. Co-culture studies revealed no evidence for excessive suppressor cell activity resulting in the decreased AMLR. However, enumeration of T cells reactive with the monoclonal antibody T29, which recognizes a subset of T cells proliferating in the AMLR, demonstrated that AD patients (n = 8; % T29 = 2.5±0.7) had a significantly decreased (P < 0.001) number of circulating T29+ T cells when compared with normal controls (n = 8; % T29

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Section: Introductionsupporting

confidence: 66%

Impairment of the autologous mixed lymphocyte reaction in atopic dermatitis.

Leung¹,

Saryan²,

Frankel³

et al. 1983

J. Clin. Invest.

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“…This pattern is similar to the findings in other studies. 4,5 Nummular eczema (discoid eczema) occurred in 25.7% of cases seen in this study. Distribution among the various age groups was generalized, though it was rarely seen in infants.…”

Section: Discussionmentioning

confidence: 56%

The Pattern of Endogenous Eczema in the Northern Frontier, Kingdom of Saudi Arabia

Kubeyinje

1995

Ann Saudi Med

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“…은 유사하지만 이전의 Hanifin과 Lobitz [12]가 제안한 진 단기준을 근거로 피부과 의사들이 검진한 결과 6세 이하 어 린이에서 11.2%의 유병률을 보고한 이래 여러 보고에서 6세 이하의 소아에서 6.1%, 초등학교 연령에서는 3.7% 이후에 는 좀 더 감소하는 것으로 보고된 바 있다 [13].…”

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Current status and characteristics of atopic dermatitis in Korea

Kim

2014

J Korean Med Assoc

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Atopic dermatitis (AD) is a very common disease with a prevalence of 15 to 25%, especially in Western countries, and seems to be increasing worldwide and in Korea. The prevalence of AD in Korea is considered to be about 10% in the pediatric population less than 6 years of age and decreases thereafter, falling to about 3% in adults. AD in Korea seems to be a little more common in girls than in boys. Infragluteal eczema, scalp scaling, and periauricular eczema, which are not included in the worldwide diagnostic criteria, are reported to be quite common in Korean AD patients. Recently, the number of adult patients with a more severe form of AD appears to be increasing in Korea. Many Korean patients are more likely to seek treatments that are not proven to be effective scientifically, and patient education is of utmost importance.

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Newer concepts of atopic dermatitis

Cited by 97 publications

References 0 publications

Impairment of the autologous mixed lymphocyte reaction in atopic dermatitis.

Impairment of the autologous mixed lymphocyte reaction in atopic dermatitis.

The Pattern of Endogenous Eczema in the Northern Frontier, Kingdom of Saudi Arabia

Current status and characteristics of atopic dermatitis in Korea

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