Newer Concepts of Experimental Obesity

Etiology of Severe Obesity: A Study of Five Cases

“…The metabolic setting may determine whether a person will or will not become obese as a result of hyperphagia and increased food intake, and is therefore of great importance in the development of this disease. This is evident from a consideration of hyperthyroidism (2). It is also conceivable that certain types of diets may eventually lead to obesity through induced metabolic changes; for example, by increased demands on the insulin requirement, with an effect equivalent to that of partial pancreatectomy (24).…”

“…The obese person often responds temporarily, only to return to the same sad state and to seek new panaceas. The recurrent cycles of weight loss and gain are perhaps analogous (2) to those in the hypothalamic obese animal (3) receiving a reducing diet: There seems to be a level beyond which weight loss leads only to renewed hyperphagia and the consequent recurrent gain in weight.…”

Hypothalamic Obesity in Acute Leukaemia

“…In the literature we have only been able to trace 6 cases of obesity in acute leukaemia (4,14,15,17). In 4 of these, the central nervous system was subjected to histological studies.…”