Newer insights into the drug delivery approaches of α-glucosidase inhibitors

Kumar, Rajiv; Sinha, Vivek Ranjan

doi:10.1517/17425247.2012.663080

Cited by 29 publications

(37 citation statements)

References 55 publications

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“…It is especially important because of well-known adverse events of acarbose and other -glucosidase inhibitors on the gastrointestinal tract function [Kumar et al, 2012]. However, one of the most important issues is to calculate an effective human dose of a bioactive substance.…”

Section: Resultsmentioning

confidence: 99%

Suppression of Postprandial Glycaemia by L-Arabinose in Rats is More Associated with Starch Than Sucrose Ingestion - a Short Report

Jurgoński¹,

Krotkiewski²,

Juśkiewicz³

et al. 2015

Pol. J. Food Nutr. Sci.

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The aim of this study was to verify the glycaemia-lowering activity of L-arabinose. The experiment was conducted on 3 individual days, each separated by a week. At the beginning of each week rats were subjected to an oral glucose, sucrose or starch tolerance test. Five minutes prior to each test rats were gavaged with water (a control), an aqueous solution of acarbose (a positive control) and L-arabinose. There was no effect of L-arabinose on glycaemia in the glucose tolerance test, whereas it reduced postprandial glycaemia after 15 min of the sucrose tolerance test. In the starch tolerance test, the glycaemia after L-arabinose ingestion was signifi cantly decreased both at time intervals and in total. Inhibition of enzyme activity involved in starch digestion (amylase, maltase) may be suggested as the most probable mechanism responsible for the observed effects.Brought to you by | MIT Libraries Authenticated Download Date | 5/12/18 11:54 AM

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Section: Resultsmentioning

confidence: 99%

Suppression of Postprandial Glycaemia by L-Arabinose in Rats is More Associated with Starch Than Sucrose Ingestion - a Short Report

Jurgoński¹,

Krotkiewski²,

Juśkiewicz³

et al. 2015

Pol. J. Food Nutr. Sci.

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“…α-GIs can be used in all patients with postprandial hyperglycaemia; however, its potency suggests it is highly effective in patients with relatively mild type 2 diabetes with postprandial hyperglycaemia. 21 The fasting blood glucose levels of the STZ-NA rats used in the mitiglinide combination study were not significantly different from those of the normal rats. However, they showed a higher transition in blood glucose than the normal rats did in the OSTT.…”

Section: Discussionmentioning

confidence: 81%

“…Voglibose is an α‐GI, which suppresses glucose absorption from the small intestine by inhibiting α‐glucosidase, which converts disaccharides to glucose. α‐GIs can be used in all patients with postprandial hyperglycaemia; however, its potency suggests it is highly effective in patients with relatively mild type 2 diabetes with postprandial hyperglycaemia . The fasting blood glucose levels of the STZ‐NA rats used in the mitiglinide combination study were not significantly different from those of the normal rats.…”

Section: Discussionmentioning

confidence: 96%

“…In diabetes treatment, insulin sensitizers are used for patients with strong insulin resistance or who are overweight or obese. α‐GIs are used for patients with insulin‐independent postprandial hyperglycaemia who do not exhibit very high fasting blood glucose levels . Furthermore, SGLT2 inhibitors that also inhibit SGLT1 have been recently used .…”

Section: Introductionmentioning

confidence: 99%

“…α-GIs are used for patients with insulin-independent postprandial hyperglycaemia who do not exhibit very high fasting blood glucose levels. 20,21 Furthermore, SGLT2 inhibitors that also inhibit SGLT1 have been recently used. 22 Mitiglinide is combined with these drugs in clinical practice because it is unlikely to negate their effects when used in combination.…”

Section: Introductionmentioning

confidence: 99%

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Effects of combination of mitiglinide with various oral antidiabetic drugs in streptozotocin‐nicotinamide‐induced type 2 diabetic rats and Zucker fatty rats

Akahane

Ojima

Yokoyama

et al. 2017

Clin Exp Pharma Physio

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We examined the effects of combining the rapid insulin secretagogue, mitiglinide, with various oral hypoglycaemic drugs including biguanides, pioglitazone, α-glucosidase inhibitors, and sodium-glucose co-transporter 2 inhibitors in a rat model of type 2 diabetes. The oral glucose tolerance test (OGTT) using glucose, sucrose, or a liquid meal was used to compare the effects of mitiglinide with those of the four oral hypoglycaemic drugs and examine their combined effects on blood glucose levels and insulin secretion in the rat model. The combination of mitiglinide with other oral hypoglycaemic drugs suppressed the plasma glucose levels more than either agent did alone. Furthermore, the combination of these agents decreased insulin secretion more than mitiglinide did alone. These results indicate that mitiglinide is suitable for use in combination with other hypoglycaemic drugs because it inhibits postprandial hyperglycaemia by rapidly stimulating insulin secretion.

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Recent Advances in Effect‐directed Enzyme Assays based on Thin‐layer Chromatography

Bräm

Wolfram

2017

Phytochemical Analysis

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Thin-layer chromatography (TLC) together with its more modern form high-performance thin-layer chromatography (HPTLC) is a rapid and cost effective analytical tool with a long tradition in quality control of medicinal plants, extracts and natural products. Separated compounds are fixed on the solid silica phase to form a compound library. Through direct coupling of visualisable enzyme reactions on the TLC plate, this compound library can also be used for activity screening. Such TLC-based bioautographic enzyme and enzyme inhibition assays complement first stage development activity screening assays. They provide not only phytochemical results by chromatographic separation, but also additional information about the activity of constituents or fractions in multi-compound mixtures, and thus can reveal and distinguish artefacts generated by certain compound classes. This review summarises recently introduced TLC bioautographic enzyme assays as well as advances in already existing procedures. Bioautographic enzyme and enzyme inhibitory assays offer a rapid, high-throughput method for screening of secondary metabolite profiles for potential enzyme and enzyme inhibitory activities. Copyright © 2017 John Wiley & Sons, Ltd.

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Newer insights into the drug delivery approaches of α-glucosidase inhibitors

Abstract: It is concluded that development of a successful controlled-release delivery system for these drugs will obviate the need of repeated administration, which in turn will improve patient compliance.

Cited by 29 publications

References 55 publications

Suppression of Postprandial Glycaemia by L-Arabinose in Rats is More Associated with Starch Than Sucrose Ingestion - a Short Report

Suppression of Postprandial Glycaemia by L-Arabinose in Rats is More Associated with Starch Than Sucrose Ingestion - a Short Report

Effects of combination of mitiglinide with various oral antidiabetic drugs in streptozotocin‐nicotinamide‐induced type 2 diabetic rats and Zucker fatty rats

Recent Advances in Effect‐directed Enzyme Assays based on Thin‐layer Chromatography

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