This work presents a thorough derivation of the full-wave transmissionline equations on the basis of Maxwell's theory. The multiconductor system is assumed to be composed of nonuniform thin wires. It is shown that the mixed potential integral equations are equivalent to generalized telegrapher equations. Novel, exact, and compact expressions for the multiconductor transmission-line parameters are derived, and their connection to radiation effects is shown. Iteration and perturbation procedures are proposed for the solution of the generalized transmission-line equations.