Newly Developed Antibiotic Combination Therapy for Ulcerative Colitis: A Double-Blind Placebo-Controlled Multicenter Trial

Ohkusa, Toshifumi; Kato, Kimitoshi; Terao, Shuichi; Chiba, Tetsuhiro; Mabe, Katsuhiro; Murakami, Kazunari; Mizokami, Yuji; Sugiyama, Toshiro; Yanaka, Akinori; Takeuchi, Yoji; Yamato, Shigeru; Yokoyama, Tetsuji; Okayasu, Isao; Watanabe, Sumio; Tajiri, Hisao; Sato, Nobuhiro

doi:10.1038/ajg.2010.84

Cited by 122 publications

(96 citation statements)

References 29 publications

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“…In addition, antibiotics can transiently diminish IBD activity even in absence of CDI. [19][20][21] Similarly, absence of a clear antibiotic trigger temporally associated with the initial diagnosis of CDI is not a reliable factor because IBD alone can be associated with marked dysbiosis, sufficient to allow CDI.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Recurrent Clostridium Difficile Infection using Fecal Microbiota Transplantation in Patients with Inflammatory Bowel Disease

Newman¹,

Rank²,

Vaughn³

et al. 2017

Gastroenterology

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Section: Discussionmentioning

confidence: 99%

Treatment of Recurrent Clostridium Difficile Infection using Fecal Microbiota Transplantation in Patients with Inflammatory Bowel Disease

Newman¹,

Rank²,

Vaughn³

et al. 2017

Gastroenterology

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“…Antibiotics could be used to reduce the burden of commensal bacteria for the treatment of IBD [89]. Spontaneous colitis in IL-10 deficient mice could be prevented with the disruption of the MyD88 signaling pathway [90], which indicates that IL-10 regulates commensal bacteria driven colitis through the MyD88 pathway.…”

Section: Inflammatory Bowel Disease (Ibd)mentioning

confidence: 99%

Reciprocity in Microbiome and Immune System Interactions and its Implications in Disease and Health

Nikoopour¹,

Singh

2014

IADT

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“…On the basis of these observations, we employed a combined regimen of F. varium-susceptible antibiotics (amoxicillin, tetracycline, and metronidazole [ATM]) in both a randomized controlled pilot study and a double-blind placebo-controlled multicenter trial. This regimen demonstrated significant efficacy in active UC (4,5).…”

Section: Introductionmentioning

confidence: 99%

Nested Culture Method Improves Detection of Fusobacterium from Stool in Patients with Ulcerative Colitis

et al. 2013

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SUMMARY:Fusobacterium varium is an elusive pathogenic factor in ulcerative colitis (UC); conventional methods of fecal culture rarely recover F. varium. We have developed a nested culture method to recover Fusobacterium and we used it to investigate whether F. varium could be isolated from UC patients. We enrolled 50 consecutive patients in this study; 26 received combination antibiotic therapy that included amoxicillin, tetracycline, and metronidazole (ATM) for 2 weeks and were thus assigned to the ATM group, and the remaining 24 were assigned to the non-ATM group and did not receive any antibiotics. Stool samples were added to 10 ml of GAM broth that contained neomycin and crystal violet. The samples were vortexed and incubated under anaerobic conditions. The preincubated broth was streaked onto a Fusobacterium-selective agar plate and then incubated under anaerobic conditions. The species of the colonies isolated were identified using the Vitek Automated system and PCR analysis. We recoverd F. varium from 7 of the 24 non-ATM patients (29.2z) and none from the ATM patients (0z) ( P ＝ 0.0035). All of the F. varium isolates were susceptible to ATM. This study suggests that the recovery of F. varium is related to UC, which aligns with results from previous studies that used mucosal culture, immunostaining, real-time PCR, and serological studies.

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Newly Developed Antibiotic Combination Therapy for Ulcerative Colitis: A Double-Blind Placebo-Controlled Multicenter Trial

Abstract: The 2-week triple antibiotic therapy produced improvement, remission, and steroid withdrawal in active UC more effectively than a placebo.

Cited by 122 publications

References 29 publications

Treatment of Recurrent Clostridium Difficile Infection using Fecal Microbiota Transplantation in Patients with Inflammatory Bowel Disease

Treatment of Recurrent Clostridium Difficile Infection using Fecal Microbiota Transplantation in Patients with Inflammatory Bowel Disease

Reciprocity in Microbiome and Immune System Interactions and its Implications in Disease and Health

Nested Culture Method Improves Detection of Fusobacterium from Stool in Patients with Ulcerative Colitis

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