The aim of this study was to examine (a) how life stress, work-family conflict, social support, psychological distress, and relationship satisfaction develop over the course of military-induced separations; (b) what best predicts relationship satisfaction after being separated for several months; and (c) whether the effects were mediated by spousal interaction. Longitudinal data were collected among 153 spouses of Dutch military personnel before, during, and after military-induced separations. Analyses demonstrated a significant decrease in relationship satisfaction, psychological distress, and social support over time. Controlling for predeployment levels of relationship satisfaction, work-family conflict, social support, psychological distress, and spousal interaction made significant contributions to the explanation of relationship satisfaction after military-induced separations. However, the effects on relationships varied for each stage of the work-related spousal separation. Hence, clinical implications for psychological service delivery suggested by these findings are impacted by the stage of the work-related spousal separation. Specifically, before the separation, services might focus upon balancing work and family demands; during the separation, services that facilitate building networks are important; and finally, communication remains the key service focus upon reunion.