2017
DOI: 10.1016/j.drudis.2017.04.008
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Next-generation superparamagnetic iron oxide nanoparticles for cancer theranostics

Abstract: Superparamagnetic nanoparticles of iron oxides (SPIO) have been intensively studied for the development of contrast agents in magnetic resonance imaging (MRI). First generation SPIO had diagnostic capabilities only, while a new generation of SPIO have multifunctional characteristics for combined therapeutic and diagnostic applications. These theranostic nanoparticles hold great potential for image-guided cancer therapies. Especially, polymer-coated theranostic SPIO have enjoyed increasing attention due to good… Show more

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Cited by 123 publications
(77 citation statements)
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“…Chemotherapeutic drugs generally attached to iron NPs are characterized by low molecular weights, rapid biodistribution, and rapid clearance. Once attached to iron NPs, blood circulation time is increased as well as EPR effects, enhancing tumor retention [116,117]. Metallic NPs include iron, gold, silver, zinc, and titanium, and can be produced on a large scale, although they have to demonstrate their good tolerance and the lack of body accumulation over time if chronic administration is to be realized.…”
Section: Metallic Nanoparticlesmentioning
confidence: 99%
“…Chemotherapeutic drugs generally attached to iron NPs are characterized by low molecular weights, rapid biodistribution, and rapid clearance. Once attached to iron NPs, blood circulation time is increased as well as EPR effects, enhancing tumor retention [116,117]. Metallic NPs include iron, gold, silver, zinc, and titanium, and can be produced on a large scale, although they have to demonstrate their good tolerance and the lack of body accumulation over time if chronic administration is to be realized.…”
Section: Metallic Nanoparticlesmentioning
confidence: 99%
“…The biomedical interest in superparamagnetic iron oxide nanoparticles (SPION) is due to their biocompatibility, surface engineering capability and enhanced magnetic properties [1][2][3]. This material has been applied in drug delivery systems, magnetic fluid hyperthermia (MFH) [4,5] and contrast agent for magnetic resonance imaging [6]. Theranostics systems, whose diagnosis and treatment are carried out on a single platform, has also been investigating [7,8].…”
Section: Introductionmentioning
confidence: 99%
“…They do not show any dramatic toxicity and have interesting cellular and in vivo interactions, making them extremely attractive as theranostic agents [29].…”
Section: Cellular Uptake and Biodistribution Of Superparamagnetic Iromentioning
confidence: 99%