NF-κB and cell-cycle regulation: the cyclin connection

Joyce, David A.; Albanese, Chris; Steer, Jay; Fu, Maofu; Bouzahzah, Boumediene; Pestell, Richard G.

doi:10.1016/s1359-6101(00)00018-6

Cited by 363 publications

(278 citation statements)

References 214 publications

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“…Second, persistent expression of D-type cyclins in post-mitotic cells may be explained by their participation in non-cell cycle mediated processes. This hypothesis is consistent with data that support cell cycle-independent transcriptional up-regulation and functions of D-type cyclins in various cellular contexts (Amanatullah et al, 2002;Coqueret, 2002Coqueret, , 2003Fu et al, 2004;Jian et al, 2005;Joyce et al, 2001;Kenney and Rowitch, 2000;Pestell et al, 1999;Wang et al, 2004). More recently, a combined genetic-proteomic analysis identified several non-cell cycle proteins that interact with cyclin D1 (Bienvenu et al, 2010).…”

Section: Discussionsupporting

confidence: 88%

Segment- And Cell-Specific Expression of Dtype Cyclins in the Postnatal Mouse Epididymis

Wang

2007

Biology of Reproduction

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Sperm transport, maturation and storage are the essential functions of the epididymis. The epididymis in the mouse is structurally characterized by regional and segmental organization including caput, corpus and cauda epididymis that are comprised of ten segments. Although several growth factor signaling pathways have been discovered in the epididymis, how these converge onto the cell cycle components is unknown. To begin to elucidate the growth factor control of cell cycle events in the epididymis, we analyzed the expression of D-type cyclins at different postnatal ages. At 7d, cyclin D1 was mainly expressed in the cauda epithelium, by 14d its expression occurred in the epithelium of caput, corpus and cauda that persisted up to 21d. By 42d, cyclin D1 was mostly detectable in the principal cells of the caput and corpus (segments 1-7) but not in the cauda epididymis. Expression of cyclin D2, unlike that of cyclin D1, was evident only at 42d but not earlier, and was mostly confined to corpus and cauda epithelium. In contrast to both cyclin D1 and D2, cyclin D3 was expressed primarily in the interstitium at 7d and by 21d its expression was localized to the epithelium of the corpus and cauda epididymis. By 42d, expression of cyclin D3 peaked in segments 6-10 and confined to basal and principal cells of the corpus and apical cells of the cauda epithelium. Ki67 immunoreactivity confirmed absence of cell proliferation despite continued expression of D-type cyclins in the adult epididymis. Collectively, on the basis of our immunophenotyping and protein expression data, we conclude that the D-type cyclins are expressed in a development -, segment-, and cell-specific manner in the postnatal mouse epididymis.

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Section: Discussionsupporting

confidence: 88%

Segment- And Cell-Specific Expression of Dtype Cyclins in the Postnatal Mouse Epididymis

Wang

2007

Biology of Reproduction

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“…Cytokines by binding to their cognate receptors on tumor cells could provide proliferative signals that could counter apoptotic effects of TRAIL. In addition, TRAIL-induced stimulation of tumor cell proliferation could be a result of involvement of other mechanisms, such as activation cyclin kinases and stimulation cell cycle [25][26][27]. Moreover, activation of downstream caspases could trigger cellcycle arrest and development of senescence in some of the surviving cells (Figure 8).…”

Section: Discussionmentioning

confidence: 99%

“…TRAIL signaling via cognate receptors activates various signaling pathways, including MAPKs, PKB/Akt-and NF-κB-signaling cascades that could ultimately activate cyclin kinases and stimulate cell cycle [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Multiple effects of TRAIL in human carcinoma cells: Induction of apoptosis, senescence, proliferation, and cytokine production

Levina

Marrangoni

DeMarco

et al. 2008

Experimental Cell Research

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TRAIL is a death ligand that induces apoptosis in malignant but not normal cells. Recently the ability of TRAIL to induce proliferation in apoptosis-resistant normal and malignant cells was reported. In this study, we analyzed TRAIL effects in apoptosis sensitive MCF7, OVCAR3 and H460 human tumor cell lines. TRAIL at low concentrations preferentially induced cell proliferation. At 100 ng/ ml apoptotic death was readily observed, however surviving cells acquired higher proliferative capacity. TRAIL stimulated production of several cytokines, IL-8, RANTES, MCP-1 and bFGF, and activation of caspases 1 and 8 was essential for this effect. Antibodies to IL-8, RANTES, and bFGF blocked TRAIL-induced cell proliferation and further stimulated apoptosis. For the first time, we report that high TRAIL concentrations induced cell senescence as determined by altered morphology and expression of several senescence markers: SA-β-gal, p21 Waf1/Cip1 , p16 INK4a , and HMGA. Caspase 9 inhibition protected TRAIL-treated cells from senescence, whereas inhibition of caspases 1 and 8 increased yield of SLP cells. In conclusion, in cultured human carcinoma cells, TRAIL therapy results in three functional outcomes, apoptosis, proliferation and senescence. TRAIL induced proapoptotic and prosurvival responses correlate with strength of signaling. TRAIL-induced cytokine production is responsible for its proliferative and prosurvival effects.

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“…PKB/Akt is known to control the NF-nB level by phosphorylating downstream proteins (IKK and InB), which in turn release NF-nB from its complex [24]. NF-nB then translocates to the nucleus where it induces the transcription of growth factors including TNF-a and the oncogene cyclin D1 [25]. The latter was found to be directly related to chemoresistance.…”

Section: Discussionmentioning

confidence: 99%

389 CF101, an agonist to the A3 adenosine receptor enhances the chemotherapeutic effect of 5-fluorouracil in a colon carcinoma murine model

Fishman¹,

Yehuda²,

Madi³

et al. 2004

European Journal of Cancer Supplements

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NF-κB and cell-cycle regulation: the cyclin connection

Cited by 363 publications

References 214 publications

Segment- And Cell-Specific Expression of Dtype Cyclins in the Postnatal Mouse Epididymis

Segment- And Cell-Specific Expression of Dtype Cyclins in the Postnatal Mouse Epididymis

Multiple effects of TRAIL in human carcinoma cells: Induction of apoptosis, senescence, proliferation, and cytokine production

389 CF101, an agonist to the A3 adenosine receptor enhances the chemotherapeutic effect of 5-fluorouracil in a colon carcinoma murine model

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