2020
DOI: 10.3390/ijms21239181
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NF-κB and Disease

Abstract: The role of NF-κB in all diseases characterized by an inflammatory process, from cancer to autoimmune diseases, is known, but—precisely because it is involved in many diseases—this transcriptional factor continues to attract scientific research and the new knowledge that emerges is fundamental in highlighting the therapeutic potential that this factor can have in the various diseases in which it is involved [...]

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Cited by 85 publications
(46 citation statements)
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“…The NF-κB signaling pathway is composed of canonical signaling pathways activated via various stimuli with a rapid but transient transcriptional activity, as well as non-canonical signaling pathways stimulated via TNF receptor superfamily members ( 23 ). Previous studies have verified the pivotal role of NF-κB signaling in tumors and diseases ( 24 , 25 ). Furthermore, the NF-κB signaling pathway promotes RA ( 26 , 27 ).…”
Section: Introductionmentioning
confidence: 78%
“…The NF-κB signaling pathway is composed of canonical signaling pathways activated via various stimuli with a rapid but transient transcriptional activity, as well as non-canonical signaling pathways stimulated via TNF receptor superfamily members ( 23 ). Previous studies have verified the pivotal role of NF-κB signaling in tumors and diseases ( 24 , 25 ). Furthermore, the NF-κB signaling pathway promotes RA ( 26 , 27 ).…”
Section: Introductionmentioning
confidence: 78%
“…Transcription factor NF-kB is known to be the marker of the inflammatory activation of cells [ 45 , 46 ]. Therefore, we studied the activity of the transcription factor NF-kB and analyzed in cells the content of the anti-apoptotic proteins Mcl-1, Bcl-2, Bcl-xL, Bcl-w, and Bfl-1 which are under the control of NF-kB [ 47 ].…”
Section: Resultsmentioning
confidence: 99%
“…The TLR4/NF-κB pathway is a recently discovered signal pathway that is closely related to the anti-inflammatory immune mechanism; it is widely involved in the expression and regulation of genes involved in cell survival, proliferation, and differentiation. 45–48 TLR-4 is one of the proteins upstream of NF-κB; it can phosphorylate S536 on the NF-κBp65 subunit through the MYD88 non-dependent pathway and MYD88-dependent pathway. Furthermore, the free NF-kB can enter the nucleus and bind to the targeted DNA, which induces the expression of the pro-inflammatory cytokines TNFα and IL-6.…”
Section: Discussionmentioning
confidence: 99%