Lyophyllum decastesfruiting body polysaccharide alleviates acute liver injury by activating the Nrf2 signaling pathway

Abstract

Polysaccharides have high antioxidant, hypoglycemic, hypolipidemic, hepatoprotective and anti-tumor activities, as well as high anticancer activity. In this study, Lyophyllum decastes fruiting body polysaccharide (LDFP) is used as the research...

Suppression of endoplasmic reticulum stress-associated pathways and hepatocyte apoptosis participates in the attenuation of betulinic acid on alcohol-provoked liver injury in mice

“…Male Kunming mice were used as the alcoholic liver injury model. 22,23 Male Kunming mice (20 ± 2 g) were purchased from Hunan Silaikejingda Experimental Animal Co., Ltd (Changsha, Hunan, China) and housed in an environment with 12-hour light and dark cycles at a temperature of 20-25 °C and relative humidity of 50% to 70%. The animal experiments were conducted under the Animal Care Committee of Hunan Agricultural University and performed according to the Animal Care and Use Guidelines of China (approval code: 43321820).…”

Morphology and Phylogeny of Lyophylloid Mushrooms in China with Description of Four New Species

“…[ 1 , 4 , 5 ]. In addition, some species of Lyophyllum , Calocybe Kühner, Hypsizygus Singer, and Termitomyces R. Heim have edible value [ 6 ], and a few species have medicinal and significant economic importance [ 7 , 8 , 9 , 10 ]. In particular, Lyophyllum shimeji (Kawam.)…”

Complete genome sequences and comparative secretomic analysis for the industrially cultivated edible mushroom Lyophyllum decastes reveals insights on evolution and lignocellulose degradation potential

“…Lyophyllum decastes is proved to be a health-promoting supplement due to its antitumor (Kim et al, 1984;Ukawa et al, 2000;Ding et al, 2022), antidiabetic (Miura et al, 2002), antihypertension (Kokean et al, 2005), anti-hyperlipidemic (Ukawa et al, 2002;Wang T. et al, 2022), immunoregulation (Ding et al, 2022), hepatic-protection (Zhang et al, 2022), radioprotection (Nakamura et al, 2007), and skin lesion protection effects (Ukawa et al, 2007). Polysaccharides were the major bioactive compounds characterized in L. decastes (Ukawa et al, 2000;Ding et al, 2022;Wang T. et al, 2022;Zhang et al, 2022). Pokhrel et al investigated the optimistic submerged culture conditions for mycelial yield and polysaccharide production by L. decastes and found that a concentration of glucose 3% + yeast extract 1% was a suitable condition for submerged culture (Pokhrel and Ohga, 2007).…”