Suppression of endoplasmic reticulum stress-associated pathways and hepatocyte apoptosis participates in the attenuation of betulinic acid on alcohol-provoked liver injury in mice

Abstract

BA protects against alcohol-induced liver damage through the alleviation of oxidative stress and suppression of ERS-induced apoptosis.

A novel approach combining network pharmacology and experimental validation to study the protective effect of ginsenoside Rb1 against cantharidin‐induced hepatotoxicity in mice

“…There is evidence that ERS participates in the occurrence and development of various liver disorders, including fatty liver, ischemia–reperfusion injury, liver fibrosis and DILI 38–41 . Moreover, evidence has suggested that activation of ERS and apoptosis could cause liver injury, 42 which is consistent with our previous findings in LO2 cells after CTD intervention 8 . Furthermore, suppressing three branches of the ERS signalling pathway could alleviate DILI 43 …”