NF-κB triggers cell cycle arrest in epidermis via specific induction of the cyclin-dependent kinase inhibitor p21Cip1

Seitz, CS; Deng, Helen; Khavari, P

doi:10.1016/s0923-1811(98)83014-4

Cited by 3 publications

(1 citation statement)

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“…It was supposed that APCA induced cell cycle arrest and apoptosis without activation of the p53/p21 system. Another pathway reported by Seitz et al [33] was that the nuclear translocation of NF-kB contributed to the increase of p21 and the following cell cycle arrest. However, our study suggested that the intranuclear amount of NF-kB was reduced (Fig.…”

Section: Discussionmentioning

confidence: 91%

Induction of G2/M phase arrest and apoptosis by potent antitumor APCA in human cervix carcinoma cells

Liang

Wang

et al. 2011

Anti-Cancer Drugs

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3-(dimethylamino-ethylamino)-8-oxo-8H-acenaphthol[1, 2-b]pyrrole-9-carboxylic acid (APCA), as a potent antitumor compound, showed anticancer activity on a series of established cancer cells. Meanwhile, the cytotoxic effects of APCA were much smaller on normal human cells than that on cancer cells. This study investigated the molecular mechanisms underlying APCA-induced growth inhibition in HeLa cells. The results showed that the APCA-induced cell cycle arrest at G(2)/M phase correlated with cyclinB1 and cyclin-dependent kinase 1 expression downregulation in a p53-independent manner, and also caused an increase in apoptosis, which was confirmed by characteristic morphological changes and increased apoptotic sub-G(1) population. Furthermore, translocation inhibition of nuclear factor-κB, upregulation of Bax, and downregulation of Bcl-2, caspase-3 and caspase-9 activation, and poly-(ADP-ribose) polymerase cleavage were observed in HeLa cells treated with APCA, which indicated that the mitochondrial pathway was involved in the apoptosis signal pathway. In summary, APCA displayed an antitumor effect through cell cycle arrest and apoptotic induction in HeLa cells, which suggested that APCA might have therapeutic potential against cervix carcinoma as an effective lead compound.

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Section: Discussionmentioning

confidence: 91%