1999
DOI: 10.1016/s0014-2999(99)00168-5
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NG-nitro-l-arginine methylester is protective against ethanol-induced gastric damage in cholestatic rats

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Cited by 32 publications
(38 citation statements)
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“…Several studies have demonstrated increased levels of NO in cholestasis (6,21). In the present study, levels of NO in BDL only group were significantly higher than those of resveratrol-treated rats.…”
Section: Discussionsupporting
confidence: 49%
See 1 more Smart Citation
“…Several studies have demonstrated increased levels of NO in cholestasis (6,21). In the present study, levels of NO in BDL only group were significantly higher than those of resveratrol-treated rats.…”
Section: Discussionsupporting
confidence: 49%
“…The present study indicates that intraperitoneal administration of resveratrol at a dose of 10 mg/kg day reduced MDA and NO and increased GSH levels in gastric tissue after BDL in rats. A recent study showed that plasma levels of nitrite and nitrate are higher in cholestatic rats than in normal animals and this finding confirms the assumption of increased production of NO in cholestasis (21). In another study Chen et al (22) reported that endogenous NO produced by constitutive NO synthase regulates mucosal perfusion and has been suggested to protect the gastrointestinal mucosa from a variety of stimuli.…”
Section: Discussionmentioning
confidence: 70%
“…Some reports have shown that L-NAME is protective against ethanol-induced gastric damage. 29,30) Gastroprotective activity of NO against ethanol-induced ulcers has been reported in rats. 31,32) However, an ulcerogenic as well as a protective effect of NO was demonstrated in the injury of rat gastric mucosa.…”
Section: Discussionmentioning
confidence: 99%
“…[31][32][33] On the other hand, in comparison with the sham-operated group, the NO level in the gastric tissue increased in cholestatic rats in those groups receiving ASA alone or with some other substance. Nahavandi et al 26 obtained a similar result. Furthermore, ASA inhibits the cyclooxygenase pathway of arachidonate metabolism, which produces prostaglandins, which have several effects, including mucus and bicarbonate secretion, mucosal blood flow, epithelial cell replication, and repair of the mucosal immunologic function of nerve endings and of cells involved in inflammation.…”
Section: Discussionmentioning
confidence: 64%
“…6,18,26 Oxidative stress is defined as an imbalance between oxidants and antioxidants in favor of the oxidants, which potentially leads to damage. Accumulating evidence implicates reactive oxygen species in the pathogenesis of a number of disease processes.…”
Section: Discussionmentioning
confidence: 99%