Dose-Dependent Effects of Verapamil on Ethanol-Induced Gastric Lesions in Rats

Kılıç, Fatma Sultan; Sırmagül, Başar; Batu, Özlem; Erol, Kevser

doi:10.1248/jhs.52.781

Cited by 8 publications

(8 citation statements)

References 36 publications

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“…All these reductions were found to be statistically highly significant when compared with Carbachol alone. Our study is consistent with other workers who concluded that Verapamil significantly reduces gastric acid secretion (Kadalmani et al 2011;Kilie et al 2006). Verapamil, a well known calcium channel blocker inhibits the calcium influx, which may be responsible for the observed reductions in volume and acidity of gastric secretion.…”

Section: Discussionsupporting

confidence: 94%

Pharmacological effects of extract of Carthamus tinctorius on volume and acidity of stimulated gastric secretion

Mandade¹,

Sreenivas

Sakarkar³

et al. 2011

Orient Pharm Exp Med

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Over production of gastric acid in response to various stimuli is responsible for peptic ulceration in majority of patients. Calcium plays an important role in the release of various stimulant mediators. The aerial part of Carthamus tinctorius L. are reported to have calcium channel blocking activity. This study was designed to find out the effects of extract on the volume and acidity, free and total, of Carbachol induced gastric secretion and to compare the results with that of Cimetidine and Verapamil on the same parameters. The animals were kept on fasting for 48 h after which the pylorus of each animal was ligated. The extract was administered 200 and 400 mg/kg of body weight, Cimetidine 2.5 mg/kg and Carbachol 600 μg/kg and Verapamil 10 mg/kg body weight, intraperitoneally, in pylorus ligated rats. It was found that the extract reduced the volume, free and total acidity of gastric secretion, which were statistically highly significant when compared with Carbachol (P<0.001). Cimetidine also had the same effects. When the difference of mean values, brought about by extract, was compared with those of Cimetidine, it was found that these differences in the volume and free acidity were significant indicating that Cimetidine is more effective than the extract. The extract can, however, be used effectively in the treatment of peptic ulcer. Although, the extract reduced gastric acidity significantly, but is less effective than Cimetidine

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Section: Discussionsupporting

confidence: 94%

Pharmacological effects of extract of Carthamus tinctorius on volume and acidity of stimulated gastric secretion

Mandade¹,

Sreenivas

Sakarkar³

et al. 2011

Orient Pharm Exp Med

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“…The results of this study shows that amlodipine in dose of 0.5 mg/kg demonstrates anti-ulcer action in different etiologies of peptic ulcers. Similar observations were reported by Kilic et al .,[ 6 ] with verapamil in ethanol-induced gastric ulcer model and Jain et al .,[ 9 ] with verapamil and diltiazem. One previous study has demonstrated ulcer protective efficacy of amlodipine in doses 0.5 mg/kg and 1 mg/kg in pylorus ligation model in rats.…”

Section: Discussionmentioning

confidence: 99%

“…Alcohol-induced gastric ulcer: The study medications were administered 1 hour prior to induction of ulcer with ethanol (80%, 1 ml/100 gm) orally. [ 6 ]…”

Section: Methodsmentioning

confidence: 99%

“…The anti-ulcer effects of calcium channel blockers, viz ., verapamil, nifedipine and diltiazem have been reported. [ 5 6 ] All these drugs have been reported to potentiate the anti-ulcer and anti-secretory effects of famotidine at low doses. Amlodipine is currently one of the most widely prescribed calcium channel blocker (CCB) for various cardiovascular disorders.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of anti-ulcer effect of amlodipine in gastric ulcer models in rats

et al. 2012

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Aims:To study anti-ulcer effect of Amlodipine and compared it with ranitidine in indomethacin, alcohol and pyloric ligation-induced gastric ulcers in wistar rats.Materials and Methods:Gastric ulcers were induced in Wistar albino rats by oral administration of indomethacin (200 mg/kg), alcohol (80%, 1 ml/100 gm) and by pyloric ligation. Antiulcer activity of amlodipine (0.5 mg/kg, i.p.) was observed either alone or in combination with ranitidine (15 mg/kg, i.p.), on ulcer index, gastric pH and gastric volume. Statistical analysis was done by ANOVA and unpaired one tailed ‘t‘ test. P<0.05 was considered statistically significant.Results:Amlodipine produced significant (P<0.05) decrease in ulcer index and gastric pH as compared to control. It also produced significant (P<0.05) increase in gastric volume as compared to ranitidine. The anti-ulcer effects of ranitidine were significantly higher than that of amlodipine. Combination of amlodipine and ranitidine did not show significant increase in anti-ulcer activity as compared with ranitidine alone.Conclusions:Amlodipine produced significant anti-ulcer effects in all 3 experimental models. Amlodipine increased the volume of gastric secretions as compared to ranitidine.

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“…9 Dihydropyridine CCB are reported to enhance production of NO whereas as verapamil did not have any effect on NO in vitro. 12 Diltiazem is a calcium channel blocker of non-dihydropyridine type. 5 In present study, diltiazem has the property of ulcer preventing activity in diclofenac induced gastric ulcers.…”

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confidence: 99%

Evaluation of antiulcer activity of diltiazem in rats

Vare¹,

Bagle²,

Hire³

2017

Int J Basic Clin Pharmacol

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Background: The risk factors for patients with cardiovascular diseases and gastrointestinal diseases overlap. Majority of the patients have both problems coexistent. Thus, there is need of medicine that can be used for both the diseases.Methods: Rats weighing 150-250gm of either gender were procured for the study from central animal house. The animals were divided into 7 groups. Control group (Distilled water 2ml), diclofenac sodium (12mg/kg), diltiazem (10mg/kg), diltiazem (30mg/kg), diltiazem (60mg/kg), ranitidine (8mg/kg), ranitidine (16mg/kg). After six hours, scarification of animals was done by cervical dislocation. Size of ulcer, number of gastric ulcers, mean gastric irritancy index, ulcer index, and ulcer scoring were the parameters that were studied.Results: Diltiazem in dose of 10, 30 and 60 mg/kg showed reduction in all parameters in dose dependent manner. Diltiazem (60mg/kg) showed marked reduction in mean diameter of ulcerated surface area (0.46±0.36), number of ulcers (4.10±2.05), size of ulcers (1.07±0.48), total mucosal surface area (7.60±1.38), and total ulcerated surface area (0.263±0.3). Diltiazem (60mg/kg) showed significant reduction of the parameters as compared to other doses of Diltiazem. Also, diltiazem (60mg/kg) was comparable to Ranitidine in all the parameters. Diltiazem (60mg/kg) also showed reduction in average number of ulcers, ulcer index, mean gastric irritancy index and ulcer scoring as compared to diclofenac sodium (12mg/kg).Conclusions: Diltiazem has shown to have ulcer prevention property; this can be useful in patients having concomitant cardiovascular and gastrointestinal problems.

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Dose-Dependent Effects of Verapamil on Ethanol-Induced Gastric Lesions in Rats

Cited by 8 publications

References 36 publications

Pharmacological effects of extract of Carthamus tinctorius on volume and acidity of stimulated gastric secretion

Pharmacological effects of extract of Carthamus tinctorius on volume and acidity of stimulated gastric secretion

Evaluation of anti-ulcer effect of amlodipine in gastric ulcer models in rats

Evaluation of antiulcer activity of diltiazem in rats

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