Pharmacological effects of extract of Carthamus tinctorius on volume and acidity of stimulated gastric secretion

Abstract

Over production of gastric acid in response to various stimuli is responsible for peptic ulceration in majority of patients. Calcium plays an important role in the release of various stimulant mediators. The aerial part of Carthamus tinctorius L. are reported to have calcium channel blocking activity. This study was designed to find out the effects of extract on the volume and acidity, free and total, of Carbachol induced gastric secretion and to compare the results with that of Cimetidine and Verapamil on the same parameters. The animals were kept on fasting for 48 h after which the pylorus of each animal was ligated. The extract was administered 200 and 400 mg/kg of body weight, Cimetidine 2.5 mg/kg and Carbachol 600 μg/kg and Verapamil 10 mg/kg body weight, intraperitoneally, in pylorus ligated rats. It was found that the extract reduced the volume, free and total acidity of gastric secretion, which were statistically highly significant when compared with Carbachol (P<0.001). Cimetidine also had the same effects. When the difference of mean values, brought about by extract, was compared with those of Cimetidine, it was found that these differences in the volume and free acidity were significant indicating that Cimetidine is more effective than the extract. The extract can, however, be used effectively in the treatment of peptic ulcer. Although, the extract reduced gastric acidity significantly, but is less effective than Cimetidine

Safflower seed extract synergizes the therapeutic effect of cisplatin and reduces cisplatin-induced nephrotoxicity in human colorectal carcinoma RKO cells and RKO-transplanted mice

“…flowers and leaves of safflower (Carthamus tinctorius L.), a member of the chrysanthemum family, have a long history of use in traditional Chinese medicine in treatments for stroke, gynecological diseases, coronary heart disease, angina pectoris, and hypertension (5)(6)(7)(8). Furthermore, safflower has been used for centuries to treat urological diseases in China (9), and the consumption of safflower seed oil is popular worldwide.…”

Serotonins of safflower seeds play a key role in anti-inflammatory effect in lipopolysaccharide-stimulated RAW 264.7 macrophages

“…The flowers and leaves of safflower (Carthamus tinctorius L.), which belongs to chrysanthemum family, have long been used to treat stroke, gynecological diseases, coronary heart disease, angina pectoris and hypertension in traditional Chinese medicines Li et al 2009;Mandade et al 2012). Additionally, C. tinctorius seeds, which are rich in unsaturated fatty acid and α-linoleic acid, are widely used for the treatment of blood stasis, bone formation, and osteoporosis and prevention of rheumatism in Korea (Kim 1998;Seo et al 2000).…”