NGF Sensitizes Nociceptors for Cowhage- but Not Histamine-Induced Itch in Human Skin

Rukwied, Roman; Main, Maurice; Weinkauf, Benjamin; Schmelz, Martin

doi:10.1038/jid.2012.242

Cited by 52 publications

(36 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…22) Thus, increased NGF in the skin may sensitize primary afferents, thereby contributing to chronic itch such as atopic dermatitis. Interestingly, tumor necrosis factor (tnf)-α has been found to enhance NGF production in human keratinocytes.…”

Section: Nerve Elongation Factorsmentioning

confidence: 99%

An Update on Peripheral Mechanisms and Treatments of Itch

Tominaga

Takamori

2013

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Histamine H 1 -receptor blockers are used to treat all types of itch resulting from serious skin diseases such as atopic dermatitis, as well as from renal and liver diseases. However, they often lack efficacy in chronic itch, a profound clinical problem that decreases quality of life. The development of effective treatments requires a full understanding of the fundamental mechanisms of itch. Recent studies have indicated that the pathogenic mechanisms of itch also involve agonists other than histamine, including proteases, neuropeptides, cytokines, and opioids, as well as their cognate receptors. Release of these pruritogenic mediators and modulators into the periphery may directly activate itch-mediating C-fibers via specific receptors on the nerve terminals. Histological observations have shown increased epidermal nerve densities in patients with atopic dermatitis, suggesting that the higher density is at least partly responsible for itch sensitization. This

show abstract

Section: Nerve Elongation Factorsmentioning

confidence: 99%

An Update on Peripheral Mechanisms and Treatments of Itch

Tominaga

Takamori

2013

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

show abstract

“…Another example is neurotrophic factors such as NGF and artemin, which are known to sensitize nociceptors and promote thermal and mechanical hyperalgesia (Pezet and McMahon 2006;Malin et al 2006Malin et al , 2011Zhang et al 2005). NGF and artemin have also been recently shown to sensitize pruriceptors and thus enhance itching upon injection intradermally (Rukwied et al 2013;Murota et al 2012). Consistent with their role in regulating itch, the level of NGF and artemin was significantly elevated in the skin from patients with atopic dermatitis (Yamaguchi et al 2009;Murota et al 2012).…”

Section: Modulation Of Itch By Inflammatory Mediatorsmentioning

confidence: 53%

“…Consistent with their role in regulating itch, the level of NGF and artemin was significantly elevated in the skin from patients with atopic dermatitis (Yamaguchi et al 2009;Murota et al 2012). Intriguingly, NGF sensitized only cowhage-induced itch, but not histamine-induced itch (Rukwied et al 2013), which is mainly mediated by TRPV1. It is therefore tempting to speculate that the NGF receptor TrkA is not expressed in the TRPV1 + pruriceptive neurons, but present in pruriceptive neurons that mediate the action of cowhage.…”

Section: Modulation Of Itch By Inflammatory Mediatorsmentioning

confidence: 56%

Targeting TRP ion channels for itch relief

Zhang

2014

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

Acute itch (pruritus) is unpleasant and acts as an alerting mechanism for removing irritants. However, severe chronic itch is debilitating and impairs the quality of life. Rapid progress has been made in recent years in our understanding of the fundamental neurobiology of itch. Notably, several temperature-sensitive transient receptor potential (thermo-TRP) ion channels have emerged as critical players in many types of itch, in addition to pain. They serve as markers that define the itch neural pathway. Thermo-TRP ion channels are thus becoming attractive targets for developing effective anti-pruritic therapies.

show abstract

“…Zusätz-lich wurde die Rolle der mechano-und hitzeresponsiven (CMH) C-Fasern bei chronischen Prurituserkrankungen vor Kurzem beschrieben. Diese Nervenfasern vermitteln durch TRPV1 ("transient receptor potential channel V1")-Rezeptoren neben Pruritus auch thermalen Schmerz sowie Brennen und Kribbeln [22]. Die Sensibilisierung der lange bekannten CMi-Fasern alleine kann die Entstehung und Aufrechterhaltung des chronischen Pruritus nicht erklären.…”

Section: » Eine Kleinfaserneuropathieunclassified