Niacin or niacinamide? Nicotinic acid or nicotinamide? What is the difference?

Ranchoff, Richard E.; Tomecki, Kenneth J.

doi:10.1016/s0190-9622(86)80149-9

Cited by 22 publications

(14 citation statements)

References 3 publications

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“…Potential side effects from the older literature are listed in Table 2. In contrast to nicotinic acid, nicotinamide is not a vasodilator and rarely produces cutaneous flushing [66]. Other mucocutaneous adverse effects occurred in less than 1 % of subjects.…”

Section: Tolerabilitymentioning

confidence: 89%

Safety of high-dose nicotinamide: a review

et al. 2000

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Section: Tolerabilitymentioning

confidence: 89%

Safety of high-dose nicotinamide: a review

et al. 2000

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“…Nicotinic acid (niacin), an alternative form of vitamin B3, has for decades been used to treat elevated cholesterol and reduce the cardiovascular events and progression rate of atherosclerotic disease . Known side effects of nicotinic acid include flushing, nausea and vomiting, hypotension, headaches and itch, presumably due to its vasodilatory effects and release of prostaglandin D2 and other eicosanoids from the skin . These vasodilatory side effects are not generally observed with NAM …”

Section: Safety Profilementioning

confidence: 99%

Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety

Snaidr

Damian

Halliday

2019

Experimental Dermatology

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Nicotinamide is a water‐soluble vitamin B3 derivative that has many roles in medicine. This review examines the role of nicotinamide in dermatology and its actions in preventing photoageing and skin cancers in humans. Nicotinamide prevents ultraviolet radiation (UV) from reducing ATP levels and inhibiting glycolysis, thus preventing the UV radiation‐induced energy crisis. This enhances DNA repair and reduces UV‐induced suppression of immunity. Randomised controlled clinical trials have also shown that nicotinamide reduces transepidermal water loss and the development of new non‐melanoma skin cancers in high‐risk humans. This review also examines nicotinamide's safety profile.

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“…Unlike nicotinic acid, nicotinamide does not cause vasodilatory side‐effects and has been well tolerated at high doses (1.5—3 g daily) for a range of clinical and research indications including for inflammatory skin diseases, as a radiosensitiser and in diabetes prevention studies in children and adults . Nicotinamide has an established safety profile even at high doses, although a reversible elevation of liver enzymes and nausea have been reported in some patients at much higher daily doses (8 g daily) .…”

Section: Oral Nicotinamide To Reduce Actinic Cancer: the Ontrac Studymentioning

confidence: 99%

Nicotinamide for skin cancer chemoprevention

Damian

2017

Aust J Dermatology

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Nicotinamide (vitamin B 3 ) has a range of photoprotective effects in vitro and in vivo; it enhances DNA repair, reduces UV radiation-induced suppression of skin immune responses, modulates inflammatory cytokine production and skin barrier function and restores cellular energy levels after UV exposure. Pharmacological doses of nicotinamide have been shown to reduce actinic keratoses and nonmelanoma skin cancer incidence in high-risk individuals, making this a nontoxic and accessible option for skin cancer chemoprevention in this population.

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Niacin or niacinamide? Nicotinic acid or nicotinamide? What is the difference?

Cited by 22 publications

References 3 publications

Safety of high-dose nicotinamide: a review

Safety of high-dose nicotinamide: a review

Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety

Nicotinamide for skin cancer chemoprevention

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