Niacinamide

Bissett, Donald; Oblong, John E.; Berge, Cynthia A.

doi:10.1111/j.1524-4725.2005.31732

Cited by 143 publications

(91 citation statements)

References 27 publications

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“…Twelve healthy Korean women aged 20-59 years with periorbital wrinkles with scores of 3-5 on the baseline facial fine wrinkle grading scale [10] (table 1) were included in the study. Patients with a history of injection with collagen, fat or hyaluronic acid, of dermabrasion, phenol peel, ablative or lifting surgery, or of nonablative or ablative skin resurfacing laser treatment within 2 years prior were excluded.…”

Section: Methodsmentioning

confidence: 99%

Comparison of Microneedle Fractional Radiofrequency Therapy with Intradermal Botulinum Toxin A Injection for Periorbital Rejuvenation

et al. 2013

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Background: For periorbital rejuvenation, injection of botulinum toxin A (BoNT/A) is known to improve both static as well as dynamic wrinkles. A microneedle fractional radiofrequency (MFR) device was recently developed and is a novel and promising tool. Objective: This study compares the effects of these two treatment modalities on periorbital static wrinkles and lines. Methods: Twelve healthy women aged 20-59 years with periorbital wrinkles participated in this study. Each patient received one session of intradermal injection of BoNT/A on the left periorbital area and three sessions of MFR on the right. Clinical improvement, skin elasticity and subjective satisfaction were evaluated at every visit (baseline, 3, 6 and 18 weeks). Results: BoNT/A injection showed superior effects at 3 and 6 weeks. However, the MFR device showed better improvement at 18 weeks. In skin biopsies, the expression of procollagen 3 and elastin was increased on the MFR side compared to the untreated skin and the BoNT/A injection side. The patient satisfaction surveys at 3 weeks showed better satisfaction on the BoNT/A treatment side compared to the MFR treatment side. At 18 weeks, there were no significant differences in patient satisfaction between the two sides. Conclusion: BoNT/A injection rapidly improved periorbital wrinkles, but the effect decreased up to week 18. Compared to BoNT/A injection, MFR therapy showed gradual and long-term improvement in periorbital rejuvenation.

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Section: Methodsmentioning

confidence: 99%

Comparison of Microneedle Fractional Radiofrequency Therapy with Intradermal Botulinum Toxin A Injection for Periorbital Rejuvenation

et al. 2013

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“…Niacynamide (used in the study product in low concentration) has a delicate lightening effect, improves skin texture and exhibits anti-inflammatory activity [34]. Hence, it constitutes a beneficial addition to cosmetic therapy in AV patients.…”

Section: Figurementioning

confidence: 99%

New H2O2 dermocosmetic in acne skin care

Kisiel¹,

Dębowska²,

Dzilińska³

et al. 2018

Our Dermatol Online

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INTRODUCTIONAcne vulgaris (AV) is chronic inflammatory disease of sebaceous glands and hair follicles (so-called folliculosebaceous units) characterized by the presence of both non-inflammatory (i.e. microcomedones, closed comedones and open comedones) and inflammatory lesions (papules, pustules and cysts). AV is the most common skin disease in adolescents, although it is seen more and more often in adults, mostly women. It is estimated that 41% of people aged 25 to 40 suffer from acne lesions for at least 3 to 4 months per year (with a marked predominance in women -female: male ratio of 4:1) [1].AV pathogenesis is complex, involving mostly 4 interdependent pathogenic factors: (i) increased a c t i v i t y o f s e b a c e o u s g l a n d s w i t h s e b u m overproduction; (ii) hyperkeratosis of pilosebaceous duct leading to blockage of pilosebaseous units with excess keratin and sebum, causing comedo formation; (iii) colonization of sebaceous glands ducts with anaerobic bacteria Propionibacterium acnes and increased proliferation of aerobic bacteria Staphylococcus epidermidis and lipophilic yeasts Pityrosporum ovale (which cause irritant action due to free fatty acids derived from hydrolysis of sebum triglycerides); (iv) induction of inflammatory processes in the skin. Other factors involved in the formation of acne lesions include: (i) genetic predisposition (probably polygenic or autosomal dominant with variable penetrance) -genetic factors influence density of androgen receptors in sebaceous glands, 5-α reductase activity, seborrhoea intensity and sebaceous glands size [2,3]; (ii) immunological disturbances -excessive ABSTRACT Background: Acne vulgaris (AV) is a common skin disease with characteristic clinical, chronic course and different etiopathogenesis. AV occurs more and more often among adults, especially women. AV, due to the chronic nature of the skin lesions, often requires many months or even long-term treatment and proper skin care both during the period that does not require administration of drugs, as well as during and after pharmacotherapy. The aim of the study was to evaluate the safety and the anti-acne efficacy of a point-gel containing 2% H2O2 and salicylic acid (0.54%), phytic acid (1%), D-panthenol (1%) and vitamin PP (0.012%). Material and Methods: 24 patients with mild to severe AV used the study product containing hydrogen peroxide for 7 days. The condition of skin patients was assessed instrumentally (VISIA) and clinically by a dermatologist, including assessment of skin lesions visibility in the 10-point analogue scale and the number of particular acne lesions. Results: The product was well tolerated. Dermatological evaluation at day 7 showed a significant decrease in the visibility of acne lesions (P=0.0003) and a significant reduction of number of pustules (P=0.002); an insignificant decrease in numbers of papules and comedones was also observed. Instrumental analysis of VISIA showed insignificant reduction in the number and intensity of skin discolorations, epidermal irregulariti...

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“…It is a humectant, a lipid synthesis promoter, that improves skin barrier function. Panthenol also contributes to fi broblast proliferation and epidermal re-epithelization and, because of this, has been used in the treatment of wound healing, photoaging, hyperpigmentation, pruritus, and various in fl ammatory skin disorders [ 18,19 ] .…”

Section: Niacinamidementioning

confidence: 99%