Nicarbazin Induce Oxidative Response and Colony Stimulating Factor Production in Mouse lung Cells In Vitro

Aslian, Shima; Boojar, Masoud Mashhadi Akbar; Yaghmaei, Parichehreh; Amiri, Saeed Akhoondian

doi:10.13005/bbra/1244

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…The molecular mechanism of nicarbazin is based on inhibiting the development of the first and second generations of the schizont stage of the parasites. There are some molecular mechanisms proposed for nicarbazin's avian adverse effect, but no research group to date has conducted in vivo research [ 33 ]. Nicarbazin is one of the most successful drugs and is still widely used today [ 27 , 34 ].…”

Section: Strategies To Control Avian Coccidiosismentioning

confidence: 99%

Control of Avian Coccidiosis: Future and Present Natural Alternatives

Quiroz-Castañeda

Dantán-González

2015

BioMed Research International

187

147

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Numerous efforts to date have been implemented in the control of avian coccidiosis caused by the Eimeria parasite. Since the appearance of anticoccidial chemical compounds, the search for new alternatives continues. Today, no product is available to cope with the disease; however, the number of products commercially available is constantly increasing. In this review, we focus on natural products and their anticoccidial activity. This group comprises fatty acids, antioxidants, fungal and herbal extracts, and immune response modulators with proven anticoccidial activity, many of which exist as dietary supplements. Additionally, we offer an overview of the poultry industry and the economic cost of coccidiosis as well as the classical strategies used to control the disease.

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Section: Strategies To Control Avian Coccidiosismentioning

confidence: 99%

Control of Avian Coccidiosis: Future and Present Natural Alternatives

Quiroz-Castañeda

Dantán-González

2015

BioMed Research International

187

147

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“…The findings of Aslian et al. () suggest that these adverse events may be a result of oxidative stress in birds.…”

Section: Assessmentmentioning

confidence: 99%

Modification of the terms of authorisation regarding the maximum inclusion level of Maxiban® G160 (narasin and nicarbazin) for chickens for fattening

Additives¹,

Bampidis²,

Azimonti³

et al. 2019

EFS2

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Following the request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the proposed modification of the terms of the authorisation regarding the maximum inclusion level of Maxiban® G160. The FEEDAP Panel cannot conclude on the safety of Maxiban® G160 at a dose level of 70 + 70 mg/kg feed for the target species. The use of Maxiban® G160 in diets for chickens for fattening at the maximum proposed dose complies with the maximum residue levels (MRLs) in force of narasin and 4,4’‐dinitrocarbanilide (DNC) at 0‐day withdrawal except for DNC in kidney which was slightly above the MRL. Compliance with DNC MRLs was seen in all tissues at 1‐day withdrawal. Based on the available data, the FEEDAP Panel cannot conclude on the safety of Maxiban® G160 for the environment due to the risk identified for the terrestrial organisms due to DNC. Moreover, the high persistence and hydrophobicity of DNC indicate that there might be a risk for bioaccumulation but the risk for secondary poisoning was not identified. The potential of DNC to accumulate in soil over the years should be investigated by monitoring in a field study. The FEEDAP Panel would not be in the position to conclude on the efficacy of Maxiban® G160 in chickens for fattening based on the data provided for the dose of 40 + 40 mg narasin + nicarbazin/kg feed.

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