Nicardipine versus salbutamol in the treatment of premature labor. A prospective randomized study

Jannet, D.; Abankwa, Alexander; Guyard, B.; Carbonne, Bruno; Marpeau, L.; Milliez, Jacques

doi:10.1016/s0301-2115(97)02701-2

Cited by 63 publications

(34 citation statements)

References 19 publications

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“…Jannet et al [7], on comparing salbutamol with nicardipine on 45 cases of preterm labor in each group found that both mean gestational age of delivery and percentage of deliveries after 37 weeks were higher in nicardipine group (P value \ 0.05).…”

Section: Discussionmentioning

confidence: 99%

Comparative Study of Nifedipine and Isoxpurine as Tocolytics for Preterm Labor

Singh

Seth

2011

J Obstet Gynecol India

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Objectives This study was done to compare isoxpurine hydrochloride and nifedipine as tocolytic drugs for preterm labor. Methods A prospective cohort study of 832 antenatal women with preterm labor was conducted in the Department of Obstetrics & Gynecology. Out of 400 women found eligible for tocolysis, 200 were given isoxpurine hydrochloride while the other 200 were given nifedipine randomly. The data obtained was statistically analyzed on SPSS 10.0 of Windows 2003. Results Incidence of preterm labor was 22% while the incidence of preterm delivery was 20.9%. Nifedipine was twice more effective than isoxpurine hydrochloride as a tocolytic agent as a tocolytic agent (P value 0.006) while side effects were comparable (P value 0.133). In earlydiagnosed preterm labor, nifedipine had higher efficacy than isoxpurine (P value 6.45 9 10 -6 ) and also higher efficacy than its own in late diagnosed preterm labor (P value 2.08 9 10 -5 ). Conclusions There is a high incidence of preterm labor in India. Nifedipine is a better tocolytic drug than isoxpurine hydrochloride, especially when started with the earliest signs of preterm labor.

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Section: Discussionmentioning

confidence: 99%

Comparative Study of Nifedipine and Isoxpurine as Tocolytics for Preterm Labor

Singh

Seth

2011

J Obstet Gynecol India

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“…[566][567][568][569][571][572][573][574][575][578][579][580] Twelve studies excluded women with multiple gestations. [566][567][568][569]571,[574][575][576][577][578]580,581 Studies that included women with multiple gestations are denoted with an asterisk in the forest plots. 570,572,573,579,582 Data were available on the following outcomes: birth within 48 hours of intervention, birth within 7 days of intervention, spontaneous preterm birth before 37 weeks' gestation, spontaneous preterm birth before 34 weeks' gestation, perinatal mortality and admission to neonatal intensive care.…”

Section: Calcium Channel Blockersmentioning

confidence: 99%

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Honest

Ca²,

Durée³

et al. 2009

Health Technol Assess

189

146

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For primary prevention, an effective, affordable and safe intervention applied to all mothers without preceding testing is likely to be the most cost-effective approach in asymptomatic women in early pregnancy. For secondary prevention among women at risk of preterm labour in later pregnancy, a management strategy based on the results of testing is likely to be more cost-effective. Implementation of a treat-all strategy with simple interventions, such as fish oils, would be premature for asymptomatic women. Universal provision of high-quality ultrasound machines in labour wards is more strongly indicated for predicting spontaneous preterm birth among symptomatic women than direct management, although staffing issues and the feasibility and acceptability to mothers and health providers of such strategies need to be explored. Further research should include investigations of low-cost and effective tests and treatments to reduce and delay spontaneous preterm birth and reduce the risk of perinatal mortality arising from preterm birth.

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“…Among the drugs most used worldwide are calcium channel blockers (nifedipine) and β-mimetics [3]. A large number of studies assessing the effectiveness of such drugs have been published, however they fail to demonstrate a categorical superiority of any drug over the others [4,5,6,7,8,9,10,11,12,13]. Our local environment lacks well-designed studies and there is poor awareness of the differences between the one and only sympathomimetic tocolytic drug available and used in Chile (fenoterol) and those used in the rest of the world (ritodrine).…”

Section: Introductionmentioning

confidence: 99%

Nifedipine versus Fenoterol in the Management of Preterm Labor: A Randomized, Multicenter Clinical Study

Valdés

Salinas

Toledo

et al. 2012

Gynecol Obstet Invest

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Purpose: To compare the efficacy of nifedipine and fenoterol in the management of threatened preterm labor (TPL). Methods: A randomized and multicenter study assessing the tocolytic effect of nifedipine versus fenoterol in patients admitted to the participating maternity units with a diagnosis of TPL and a cost-savings study for economic assessment. For a power of 80% and an α error equal to 0.05, 132 consecutive patients were recruited during the study period; 66 patients were assigned to each group. A χ² analysis and a mean differences test were performed according to variable types and survival curves per intention-to-treat. Results: Demographics were similar in both groups. The latency period was similar in both groups (26.7 vs. 25.6; p = 0.3). There were no differences in the results obtained. Nifedipine failed more frequently to obtain tocolysis when used as a first-line agent (80 vs. 90%, p = 0.0001). The group treated with fenoterol showed more drug adverse events (57.8 vs. 19.0%, p = 0.0001). The economic assessment did not evidence a significant difference in terms of cost savings between groups treated with either drug. Conclusion: The present study failed to demonstrate either clinical or economic superiority of any of the two drugs used in TPL management. The highest failure percentage of nifedipine when used as a first-line agent should encourage further research.

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Nicardipine versus salbutamol in the treatment of premature labor. A prospective randomized study

Cited by 63 publications

References 19 publications

Comparative Study of Nifedipine and Isoxpurine as Tocolytics for Preterm Labor

Comparative Study of Nifedipine and Isoxpurine as Tocolytics for Preterm Labor

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Nifedipine versus Fenoterol in the Management of Preterm Labor: A Randomized, Multicenter Clinical Study

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