“…We would also encourage clinical experts to respond to public consultation, which is a very influential step in the production of NICE guidance. in particular the evidence on which this guidance was based [1]. Our greatest concern was that this guidance, which was intended to make the case for adoption of the product, seemed to be based on a small number of randomised trials each containing only a small number of patients, a point reiterated by Minto et al [2].…”