Nickel alendronate

Abstract

The title compound {sys­tematic name: bis(μ2-dihydrogen 4-aza­niumyl-1-hy­droxy­butane-1,1-di­phos­pho­n­ato)bis­[aqua­(dihydrogen 4-aza­nium­yl-1-hy­droxy­butane-1,1-diphospho­n­ato)nickel(II)] dihydrate}, [Ni2(C4H12NO7P2)4(H2O)2]·2H2O, was synthesiized under hydro­thermal conditions. Its structure is isotypic with the CoII analogue. The crystal structure is built up from centrosymmetric dinuclear complex mol­ecules and the structure is reinforced by a net of inter­molecular O—H⋯O and N—H⋯O hydrogen bonds. One water mol­ecule is bound to the NiII atom in the octahedral coordination sphere, while the second is part of the inter­molecular hydrogen-bond system.

Solid-State Phase Transition Mechanism and Physical–Chemical Study of the Crystal Forms of Monosodium Alendronate: Trihydrate versus Anhydrate

“…Diphosphonate (or bisphosphonate) compounds (Figure a) are commonly used in the treatment of bone diseases, e.g., osteoporosis, bone metastasis, and Paget’s disease. − Their action mechanism is directly linked to the ability to specifically inhibit the bone resorption process mediated by osteoclasts and to easily fix the bone matrix. ,− The scientific technological importance of diphosphonate anions has motivated several coordination chemistry, − structural, − and crystal engineering − studies of this class of compounds.…”