Nickel compounds in the workplaces: Occupations and activities involving high‐risk exposures in Italy

Scarselli, Alberto; Marzio, Davide Di; Marinaccio, Alessandro; Iavicoli, Sergio

doi:10.1002/ajim.22914

Cited by 5 publications

(2 citation statements)

References 15 publications

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“…In the present study, the main pattern of co-exposure includes compounds of nickel and hexavalent chromium (22% of all co-exposed workers). The levels and extent of occupational exposure to both hexavalent chromium and nickel compounds have already been analysed in detail on the basis of data recorded in SIREP following a similar methodology 23 , 24 ) . A recent study on the effects of occupational co-exposure to cadmium and lead concluded that this co-exposure, even at low levels, might have an immunomodulatory effect, suggesting a metal-induced pro-inflammatory immune response 25 ) .…”

Section: Discussionmentioning

confidence: 99%

Occupational carcinogens in Italy: an overview on exposure to cadmium and its compounds

SCARSELLI,

CORFIATI,

DI MARZIO

et al. 2024

INDUSTRIAL HEALTH

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Given the recognized carcinogenicity of cadmium, several regulatory interventions have been carried out over the years to protect exposed workers. The aim of the study is to investigate the prevalence and extent of exposure to cadmium among Italian workers. Data was collected from a nation-wide occupational exposure registry (SIREP, 1996–2022). Gender-specific statistical analysis was carried out for some exposure-related variables (cadmium compound, activity sector, occupational group, firm size). Potentially exposed workers were estimated for some industrial sectors. Concurrent exposures were investigated using cluster analysis. Overall 4,264 measurements were analyzed. Four industrial sectors were found to be most involved by cadmium exposure: base metal manufacturing, fabricated metal products, machinery and equipment, and other transport equipment (55% of measurements). Jewellery/precious-metal workers, and glass/ceramic plant operators were found to be most at exposure risk. A total of 26,470 workers potentially exposed was estimated (69% men). Concurrent exposures to other occupational carcinogens were detected quite frequently (52% of workers). Several situations of exposure and co-exposure to cadmium deserve attention and awareness in order to minimize the risks associated with workers’ health. Recognition of potentially hazardous exposure conditions is an important step in prevention strategies to better protect workers against cancer-causing agents.

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Section: Discussionmentioning

confidence: 99%

Occupational carcinogens in Italy: an overview on exposure to cadmium and its compounds

SCARSELLI,

CORFIATI,

DI MARZIO

et al. 2024

INDUSTRIAL HEALTH

Self Cite

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“…More frightening is that epidemiological reports have proved that occupational Ni exposure could lead to a high incidence of nasal and lung cancers [ 8 , 9 ]. As early as 1990, Ni and its compounds were classified as first-class carcinogens to humans by WHO’s International Agency for Research on Cancer (IARC) [ 10 ]. Interestingly, Ni is the essential element for most organisms as well, so it is impossible to avoid its widespread appearance in modern industries such as refining, electroplating, welding, and the production of nickel-cadmium batteries, or even in food people live on such as vegetables, nuts, and chocolate [ 3 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Nickel at Environmentally Relevant Concentrations on Human Corneal Epithelial Cells: Oxidative Damage and Cellular Apoptosis

et al. 2022

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Nickel (Ni) is ubiquitous in the environment and evidence has suggested that Ni can cause ocular surface inflammation, especially in fine particulate matter and personal products. Continuous daily exposure to Ni-containing dust may adversely impact the human cornea, whereas the underlying mechanism of this phenomenon remains not fully understood. Here, human corneal epithelial cells (HCEC) were employed to analyze the toxicity of Ni via detections of cell morphology, cell viability, reactive oxygen species production, cell apoptosis rate, and apoptotic gene expression levels after exposure for 24 h to uncover the damage of Ni to the cornea. A concentration-dependent inhibition of HCECs’ viability and growth was observed. In particular, Ni at 100 μM significantly decreased cell viability to 76%, and many cells displayed an abnormal shape and even induced oxidative damage of HCEC by increasing ROS to 1.2 times, and further led to higher apoptosis (24%), evidenced by up-regulation of apoptotic genes Caspase-8, Caspase-9, NF-κB, IL-1β, and Caspase-3, posing a risk of dry eye. Our study suggested that Ni induces apoptosis of HCEC through oxidative damage. Therefore, Ni pollution should be comprehensively considered in health risks or toxic effects on the ocular surface.

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Immunotoxicity of nickel: Pathological and toxicological effects

Guo

Liu

Jian

et al. 2020

Ecotoxicology and Environmental Safety

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Nickel compounds in the workplaces: Occupations and activities involving high‐risk exposures in Italy

Cited by 5 publications

References 15 publications

Occupational carcinogens in Italy: an overview on exposure to cadmium and its compounds

Occupational carcinogens in Italy: an overview on exposure to cadmium and its compounds

Effects of Nickel at Environmentally Relevant Concentrations on Human Corneal Epithelial Cells: Oxidative Damage and Cellular Apoptosis

Immunotoxicity of nickel: Pathological and toxicological effects

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