Immunotoxicity of nickel: Pathological and toxicological effects

Guo, Hongrui; Liu, Huan; Jian, Zhijie; Cui, Hengmin; Fang, Jing; Zuo, Zhicai; Deng, Junliang; Li, Yinglun; Wang, Xun; Zhao, Ling; He, Ran; Tang, Huaqiao

doi:10.1016/j.ecoenv.2020.111006

Cited by 36 publications

(16 citation statements)

References 104 publications

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“…Cytokine levels increased in Ni-induced inflammation responses, and Ni activates inflammation through toll like (TL)4-mediated nuclear factor-κB (NF-κB) and signal transduction cascades mitogen-activated protein kinase (MAPK) pathways. Ni has been indicated to inactivate NK cells and macrophages both in vitro and in vivo.” [ 163 ]…”

Section: Commonality Of Contributing Factors Between Ibd and Id - Detailsmentioning

confidence: 99%

Common contributing factors to COVID-19 and inflammatory bowel disease

Kostoff

Briggs²,

Kanduc

et al. 2021

Toxicology Reports

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Section: Commonality Of Contributing Factors Between Ibd and Id - Detailsmentioning

confidence: 99%

Common contributing factors to COVID-19 and inflammatory bowel disease

Kostoff

Briggs²,

Kanduc

et al. 2021

Toxicology Reports

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“…Nickel depresses the production of antibody, the phagocyte function, and interferon activity. 93 Arsenic (As) can alter the production of interferon and antibodies. Cell-mediated reactions are largely affected.…”

Section: Metals and Viral Infections: A Complex Interactionmentioning

confidence: 99%

Understanding the relationship between viral infections and trace elements from a metallomics perspective: implications for COVID-19

Jesus

Andrade

2020

Metallomics

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“…Ni is a well-known essential co-factor of at least nine bacterial enzymes therefore indirectly influencing human health as part of the natural microbiome or pathogens [20,[26][27][28]. Besides its high allergenic potential, Ni can also act as an immunotoxic and carcinogenic agent, can contribute to acute and chronic cardiovascular and respiratory diseases and it has revealed embryotoxic and teratogenic properties in animal studies [29][30][31][32][33][34].…”

Section: Physicochemical Properties Physiologic Functions and Toxicity Of Ni Co And Pd Ionsmentioning

confidence: 99%

Immunological Mechanisms of Metal Allergies and the Nickel-Specific TCR-pMHC Interface

Riedel

Aparicio‐Soto

Curato

et al. 2021

IJERPH

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Besides having physiological functions and general toxic effects, many metal ions can cause allergic reactions in humans. We here review the immune events involved in the mediation of metal allergies. We focus on nickel (Ni), cobalt (Co) and palladium (Pd), because these allergens are among the most prevalent sensitizers (Ni, Co) and immediate neighbors in the periodic table of the chemical elements. Co-sensitization between Ni and the other two metals is frequent while the knowledge on a possible immunological cross-reactivity using in vivo and in vitro approaches remains limited. At the center of an allergic reaction lies the capability of a metal allergen to form T cell epitopes that are recognized by specific T cell receptors (TCR). Technological advances such as activation-induced marker assays and TCR high-throughput sequencing recently provided new insights into the interaction of Ni2+ with the αβ TCR-peptide-major histocompatibility complex (pMHC) interface. Ni2+ functionally binds to the TCR gene segment TRAV9-2 or a histidine in the complementarity determining region 3 (CDR3), the main antigen binding region. Thus, we overview known, newly identified and hypothesized mechanisms of metal-specific T cell activation and discuss current knowledge on cross-reactivity.

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Immunotoxicity of nickel: Pathological and toxicological effects

Cited by 36 publications

References 104 publications

Common contributing factors to COVID-19 and inflammatory bowel disease

Common contributing factors to COVID-19 and inflammatory bowel disease

Understanding the relationship between viral infections and trace elements from a metallomics perspective: implications for COVID-19

Immunological Mechanisms of Metal Allergies and the Nickel-Specific TCR-pMHC Interface

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