Nickel Deficiency in Rats

Nielsen, Forrest H.; Myron, Duane R.; Givand, Samuel H.; Zimmerman, Thomas J.; Ollerich, Dwayne A.

doi:10.1093/jn/105.12.1620

Cited by 93 publications

(16 citation statements)

References 11 publications

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“…Arsenic compounds can sometimes be taken as poisons, while arsenic is presumed to be an essential element for livestock. 6 Whether or not it is also an essential element for humans remains to be studied.…”

Section: Introductionmentioning

confidence: 99%

Intake of different chemical species of dietary arsenic by the japanese, and their blood and urinary arsenic levels

Yamauchi

Takahashi

Mashiko

et al. 1992

Applied Organom Chemis

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We calculated the intake of each chemical species of dietary arsenic by typical Japanese, and determined urinary and blood levels of each chemical species of arsenic. The mean total arsenic intake by 35 volunteers was 195 f 235 (15.8-1039) pg As day-', composed of 76% trimethylated arsenic (TMA), 17.3% inorganic arsenic (Asi), 5.8% dimethylated arsenic (DMA), and 0.8% monomethylated arsenic (MA): the intake of TMA was the largest of all the measured species. Intake of Asi characteristically and invariably occurred in each meal. Of the intake of Asi, 45-75% was methylated in v i m to form MA and DMA, and excreted in these forms into urine. The mean measured urinary total arsenic level in 56 healthy volunteers was 129 k 92.0 pg As dm-3, composed of 64.6% TMA, 26.7% DMA, 6.7% Asi and 2.2% MA. The mean blood total arsenic level in the 56 volunteers was 0.73 f 0 . 5 7 pg dl-I, composed of 73% TMA, 14% DMA and 9.6% Asi. The urinary TMA levels proved to be significantly correlated with the whole-blood TMA levels (r=0.376; P < 0.01).

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Section: Introductionmentioning

confidence: 99%

Intake of different chemical species of dietary arsenic by the japanese, and their blood and urinary arsenic levels

Yamauchi

Takahashi

Mashiko

et al. 1992

Applied Organom Chemis

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“…The direct influence of deficient Ni supply on the reproductive performance described by Nielsen et al (68,69) could not be confirmed in studies by Schnegg and Kirchgessner (102). The Ni reserves of the progeny could, however, be lowered by depletion of the mothers.…”

Section: Nickelmentioning

confidence: 82%

A Comparative View on Trace Elements and Growth

Kirchgeßner¹,

Roth²,

Spoerl³

et al. 1977

Ann Nutr Metab

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The term ‘essentiality’ of trace elements is interpreted. The major human diseases due to trace element deficiency (Fe, Cu, Zn, Cr) are briefly considered. In growing animals the first clinical deficiency symptom most often is a growth retardation. In order to diagnose a deficient situation before the manifestation of clinical symptoms, model studies with growing animals are presented to show criteria that respond sensitively even to suboptimum intake of trace elements (Zn, Cu, Fe, Ni). Activity measurements of enzymes and hormones are found suitable. During the phase of reproduction, which is closely associated with growth, the trace element concentration in milk may provide an additional diagnostic means. In conclusion, the problems of diagnosing the supply status are discussed. A possibility for determination of the trace element requirement is indicated.

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“…The growth dependence on nickel was more signifi cant in the second depleted generation, which also showed anemia, manifested in decreased hemoglobin and hematocrit values [ 5 ]. Nickel deprivation during reproduction in rats increased perinatal mortality [ 168 ], while in breeding goats it signifi cantly decreased the success of fi rst insemination and conception rate and increased the number of breeding attempts to achieve pregnancy and the abortion rate [ 169 ]. This effect seems to be related to the ability of nickel to be involved in cyclic nucleotidegated (CNG) channel functions [ 170 ].…”

Section: Effects Of Nickel Depletion In Higher Organismsmentioning

confidence: 99%

Nickel and Human Health

Zambelli

Ciurli

2013

Metal Ions in Life Sciences

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This review focuses on the impact of nickel on human health. In particular, the dual nature of nickel as an essential as well as toxic element in nature is described, and the main forms of nickel that can come in contact with living systems from natural sources and anthropogenic activities are discussed. Concomitantly, the main routes of nickel uptake and transport in humans are covered, and the potential dangers that nickel exposure can represent for health are described. In particular, the insurgence of nickel-derived allergies, nickel-induced carcinogenesis as well as infectious diseases caused by human pathogens that rely on nickel-based enzymes to colonize the host are reviewed at different levels, from their macroscopic aspects on human health to the molecular mechanisms underlying these points. Finally, the importance of nickel as a beneficial element for human health, especially being essential for microorganisms that colonize the human guts, is examined.

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Nickel Deficiency in Rats

Cited by 93 publications

References 11 publications

Intake of different chemical species of dietary arsenic by the japanese, and their blood and urinary arsenic levels

Intake of different chemical species of dietary arsenic by the japanese, and their blood and urinary arsenic levels

A Comparative View on Trace Elements and Growth

Nickel and Human Health

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