Nickel(II) and cobalt(II) complexes of lidocaine: Synthesis, structure and comparative in vitro evaluations of biological perspectives

Tabrizi, Leila; McArdle, Patrick; Erxleben, Andrea; Chiniforoshan, Hossein

doi:10.1016/j.ejmech.2015.09.018

Cited by 53 publications

(17 citation statements)

References 122 publications

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“…Organometallic complexes applied for the treatment of cancer have attracted many biological and organometallic chemists in recent years. Although the antitumor activity of cisplatin was firstly discovered by Rosenberg et al fifty years ago, cisplatin and other platinum‐based drugs are still the leading anticancer metallodrugs . They are mainly used for the treatment of testicular, cervix, intestinal, head and neck cancers .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and biological evaluation of a cobalt(II) complex with 5‐chloro‐8‐hydroxyquinoline as anticancer agent

Zhang

Meng

Liu

et al. 2016

Applied Organom Chemis

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A new cobalt(II) complex (1) of 5‐chloro‐8‐hydroxyquinoline was prepared and structurally characterized using infrared spectroscopy, electrospray ionization mass spectrometry, elemental analysis, single‐crystal X‐ray diffraction as well as powder X‐ray diffraction. Its biological activities including DNA binding and anticancer activity were investigated. The DNA binding study of complex 1 suggested that it interacted with calf thymus DNA mainly via an intercalative binding mode. The in vitro anticancer activity of complex 1 was screened against a series of tumor cell lines as well as the normal liver cell line HL‐7702 using MTT assay. complex 1 showed much higher cytotoxicity than corresponding metal salt and ligand towards the five tested tumor cell lines, in which T‐24 was the most sensitive tumor cell line towards 1, with IC50 value of 7.04 ± 0.06 μM. complex 1 was found to greatly induce cell cycle arrest in T‐24 cells at S phase, and consequently to induce cell apoptosis in a dose‐dependent mode suggested by cell apoptosis analysis via Hoechst 33258 and acridine orange/ethidium bromide staining assays. The cell apoptosis mechanism of 1 was studied targeting the mitochondrion‐mediated pathway, since the apoptotic mechanism in the T‐24 cells treated by 1 was investigated by reactive oxygen species (ROS) detection, intracellular calcium concentration measurement and caspase‐9/3 activity assay. The results suggested that the cell apoptosis induced by 1 was closely related to the loss of mitochondrial membrane potential, ROS production and enhancement of intracellular [Ca2+], which would trigger the caspase‐9/3 activation via a mitochondrial dysfunction pathway. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and biological evaluation of a cobalt(II) complex with 5‐chloro‐8‐hydroxyquinoline as anticancer agent

Zhang

Meng

Liu

et al. 2016

Applied Organom Chemis

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“…Recently, a Co (III) Schiff base complex (Doxovir) was successful in a phase II clinical trial for the treatment of herpes simplex virus13. This study was designed to investigate the wound healing potential of applying a new Co (II) complex with a Schiff base derived from 4-dimethylaminobenzaldehyde with L-asparagine in rats.…”

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confidence: 99%

In vivo Assessment of Antioxidant and Wound Healing Improvement of a New Schiff Base Derived Co (II) Complex in Rats

El-Ferjani

Ahmad

Dhiyaaldeen

et al. 2016

Sci Rep

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Co (II) complex (CMLA) was investigated to evaluate the rate of wound healing in rats. Animals were placed into four groups: gum acacia, Intrasite gel, 10 and 20 mg/ml of CMLA. Wounds were made on the dorsal neck area, then treated with Intrasite gel or CMLA; both of these treatments led to faster healing than with gum acacia. Histology of the wounds dressed with CMLA or Intrasite gel displayed a smaller scar width, required less time to heal and showed more collagen staining and fewer inflammatory cells in comparison to wounds dressed with the vehicle. Immunohistochemistry for Hsp70 and TGF-β showed greater staining intensity in the treated groups compared to the vehicle group. Bax staining was less intense in treated groups compared to the vehicle group, suggesting that CMLA and Intrasite gel provoked apoptosis, responsible for the development of granulation tissue into a scar. CD31 protein analysis showed that the treated groups enhanced angiogenesis and increased vascularization compared to the control group. Furthermore, a significant increase in the levels of GPx and SOD and a decrease in MDA were also observed in the treated groups. This results suggest that CMLA is a potentially promising agent for the wounds treatment.

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“…In fact, dynamic quenching and static quenching are caused by diffusion and ground-state complex formation, respectively. 73 The shape of the SV plot gives information on the quenching mechanism involved. The Stern-Volmer diagram is not linear and is curved (Fig.…”

Section: In Vitro Cytotoxicity Studymentioning

confidence: 99%

Molecular design and synthesis of new dithiocarbazate complexes; crystal structure, bioactivities and nano studies

et al. 2018

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Nickel(II) and cobalt(II) complexes of lidocaine: Synthesis, structure and comparative in vitro evaluations of biological perspectives

Cited by 53 publications

References 122 publications

Synthesis, characterization and biological evaluation of a cobalt(II) complex with 5‐chloro‐8‐hydroxyquinoline as anticancer agent

Synthesis, characterization and biological evaluation of a cobalt(II) complex with 5‐chloro‐8‐hydroxyquinoline as anticancer agent

In vivo Assessment of Antioxidant and Wound Healing Improvement of a New Schiff Base Derived Co (II) Complex in Rats

Molecular design and synthesis of new dithiocarbazate complexes; crystal structure, bioactivities and nano studies

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