Nicorandil Inhibits Cyclic Strain-Induced Interleukin-8 Expression in Human Umbilical Vein Endothelial Cells

Chao, Hung Hsing; Hong, Hong Jye; Cheng, Tzu-Hurng; Shih, Neng Lang; Loh, Shih‐Hurng; Liu, Ju Chi; Chen, Jin Jer; Sung, Li Chin

doi:10.1159/000445075

Cited by 6 publications

(5 citation statements)

References 59 publications

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“…Another recent example of the bidirectional activity of nicorandil can be seen in the regulation of the expression of selected genes, such as heme oxygenase-1 or interleukin-8, by nicorandil in human umbilical vein endothelial cells (HUVECs). Only some of the observed effects were reversed by 5-HD, and thus were linked to mitoK ATP activity [ 51 ]. In addition to the other openers listed above, it has also been suggested that malonate and atpenin A5, which are inhibitors of complex II, can activate mitoK ATP channels and induce cardioprotection [ 52 , 53 ].…”

Section: Modulators Of Mitochondrial Atp-sensitive Potassium Channelsmentioning

confidence: 99%

Alternative Targets for Modulators of Mitochondrial Potassium Channels

et al. 2022

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Mitochondrial potassium channels control potassium influx into the mitochondrial matrix and thus regulate mitochondrial membrane potential, volume, respiration, and synthesis of reactive oxygen species (ROS). It has been found that pharmacological activation of mitochondrial potassium channels during ischemia/reperfusion (I/R) injury activates cytoprotective mechanisms resulting in increased cell survival. In cancer cells, the inhibition of these channels leads to increased cell death. Therefore, mitochondrial potassium channels are intriguing targets for the development of new pharmacological strategies. In most cases, however, the substances that modulate the mitochondrial potassium channels have a few alternative targets in the cell. This may result in unexpected or unwanted effects induced by these compounds. In our review, we briefly present the various classes of mitochondrial potassium (mitoK) channels and describe the chemical compounds that modulate their activity. We also describe examples of the multidirectional activity of the activators and inhibitors of mitochondrial potassium channels.

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Section: Modulators Of Mitochondrial Atp-sensitive Potassium Channelsmentioning

confidence: 99%

Alternative Targets for Modulators of Mitochondrial Potassium Channels

et al. 2022

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“…Studies also confirmed that serum zinc levels in luteal phase of a normal menstruation cycle are particularly lower than those in follicular phase ( 44 ). Some hypotheses suggested that the reduction in serum zinc during the luteal phase may be due to estrogen levels, enhancement of interleukin-1 or regulating progesterone and prolactin activity ( 45 - 47 ). Das and Chowdhury suggested that zinc is taken up by endometrial tissue during the luteal phase to regulate progesterone and estradiol binding receptors ( 48 ).…”

Section: Discussionmentioning

confidence: 99%

Comparison of serum zinc concentrations and body antioxidant status between young women with premenstrual syndrome and normal controls: A case-control study

Fathizadeh

Amani

Haghighizadeh

et al. 2016

IJRM

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Background:Premenstrual syndrome (PMS) is one of the important health problems with high incidence in young women. The exact cause of this syndrome is not clear and some theories have been declared from hormonal factors to nutritional disorders. Objective:We investigated the correlation between serum zinc and antioxidant status with PMS.Materials and Methods: In this case-control study, forty eight young girls were selected from a total sample of 110 students residing at university dormitories including PMS (n=23) and healthy (n=25) groups based on PMS questionnaire. Dietary intake questionnaire and blood samples were collected from all participants. Serum total antioxidant capacity (TAC) and zinc concentrations were also measured.Results:Serum TAC and zinc concentrations were lower in PMS patients compared with healthy groups (p<0.01 and p<0.05, respectively). Healthy controls consumed lower servings of hydrogenated oils (p<0.05). There were significant differences in terms of muscle mass between the PMS and healthy groups (p<0.05). Both serum TAC and zinc levels were negatively correlated to PMS scores (r=-0.39, p<0.05 and r= -0.36; p<0.05, respectively).Conclusion:This study shows that higher TAC and zinc serum levels are associated with lower risk of PMS. PMS cases have more hydrogenated oils than their normal counterparts.

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“…Reduced plasma levels of C-reactive protein and sE-selectin [73] Nitroglycerin No change in asymmetric dimethyl-arginine (ADMA), human soluble P-selectin, interleukin-6, tumor necrosis factor-alpha, intercellular adhesion molecule-1, and oxidized low-density lipoproteins in healthy volunteers [74] Nicorandil Increased Mst1 and p-Mst1 levels in cardiomyocytes subjected to MI injury [75] Nicorandil Inhibition of Toll-like receptor 4 (TLR4)-mediated myeloid differentiation primary response protein 88 (MyD88)-dependent nuclear factor-kappa B (NF-κB) signaling [76] Nicorandil Inhibition of cyclic strain-induced IL-8 expression [77] Nicorandil Reduced expression of 53 cytokines after percutaneous intervention in patients with coronary artery disease [78] Nicorandil Inhibition of TNF-alpha in vitro [79] Nicorandil Inhibition of the activation of NF-kappaB, expression of adhesion molecules, and cytokine production [80] Nicorandil Inhibition of TNFalpha release from lymphocytes [80] Inorganic nitrate Reduced systemic leukocyte rolling and adherence, circulating neutrophil numbers, neutrophil CD11b expression and myeloperoxidase activity [29]…”

Section: Nitroglycerinmentioning

confidence: 99%

Exogenous NO Therapy for the Treatment and Prevention of Atherosclerosis

Gori¹

2020

IJMS

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Amyl nitrite was introduced in 1867 as the first molecule of a new class of agents for the treatment of angina pectoris. In the following 150 years, the nitric oxide pathway has been the subject of a number of pharmacological approaches, particularly since when this elusive mediator was identified as one of the most important modulators of vascular homeostasis beyond vasomotion, including platelet function, inflammation, and atherogenesis. While having potent antianginal and antiischemic properties, however, nitric oxide donors are also not devoid of side effects, including the induction of tolerance, and, as shown in the last decade, of oxidative stress and endothelial dysfunction. In turn, endothelial dysfunction is itself felt to be involved in all stages of atherogenesis, from the development of fatty streaks to plaque rupture and thrombosis. In the present review, we summarize the agents that act on the nitric oxide pathway, with a particular focus on their potentially beneficial antiatherosclerotic and unwanted pro-atherosclerotic effects.

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Nicorandil Inhibits Cyclic Strain-Induced Interleukin-8 Expression in Human Umbilical Vein Endothelial Cells

Cited by 6 publications

References 59 publications

Alternative Targets for Modulators of Mitochondrial Potassium Channels

Alternative Targets for Modulators of Mitochondrial Potassium Channels

Comparison of serum zinc concentrations and body antioxidant status between young women with premenstrual syndrome and normal controls: A case-control study

Exogenous NO Therapy for the Treatment and Prevention of Atherosclerosis

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