Nicotinamide Riboside Improves Enteric Neuropathy in Streptozocin-Induced Diabetic Rats Through Myenteric Plexus Neuroprotection

Costa, Christopher J.; Cohen, Melanie W; Goldberg, D.; Mellado, Wilfredo; Willis, Dianna E.

doi:10.1007/s10620-023-07913-5

Cited by 4 publications

(1 citation statement)

References 34 publications

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“…In STZ-induced diabetic rats, i.p. administered NR every 48 h for six weeks improved enteric neuropathy through myenteric plexus neuroprotection [ 170 ].…”

Section: Nicotinamide Riboside As a Tool To Mitigate Metabolic Disordersmentioning

confidence: 99%

Nicotinamide Riboside, a Promising Vitamin B3 Derivative for Healthy Aging and Longevity: Current Research and Perspectives

Biță

Scorei²,

Ciocîlteu

et al. 2023

Molecules

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Many studies have suggested that the oxidized form of nicotinamide adenine dinucleotide (NAD+) is involved in an extensive spectrum of human pathologies, including neurodegenerative disorders, cardiomyopathy, obesity, and diabetes. Further, healthy aging and longevity appear to be closely related to NAD+ and its related metabolites, including nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). As a dietary supplement, NR appears to be well tolerated, having better pharmacodynamics and greater potency. Unfortunately, NR is a reactive molecule, often unstable during its manufacturing, transport, and storage. Recently, work related to prebiotic chemistry discovered that NR borate is considerably more stable than NR itself. However, immediately upon consumption, the borate dissociates from the NR borate and is lost in the body through dilution and binding to other species, notably carbohydrates such as fructose and glucose. The NR left behind is expected to behave pharmacologically in ways identical to NR itself. This review provides a comprehensive summary (through Q1 of 2023) of the literature that makes the case for the consumption of NR as a dietary supplement. It then summarizes the challenges of delivering quality NR to consumers using standard synthesis, manufacture, shipping, and storage approaches. It concludes by outlining the advantages of NR borate in these processes.

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“…In STZ-induced diabetic rats, i.p. administered NR every 48 h for six weeks improved enteric neuropathy through myenteric plexus neuroprotection [ 170 ].…”

Section: Nicotinamide Riboside As a Tool To Mitigate Metabolic Disordersmentioning

confidence: 99%

Nicotinamide Riboside, a Promising Vitamin B3 Derivative for Healthy Aging and Longevity: Current Research and Perspectives

Biță

Scorei²,

Ciocîlteu

et al. 2023

Molecules

View full text Add to dashboard Cite

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Effects of chitosan and its oligosaccharide on gut microbiota and metabolites disturbed by excessive protein consumption in vivo and in vitro

Wang,

Wang

et al. 2024

Food Bioscience

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Enteric neuroprotection—A matter of balancing redox potentials, limiting inflammation, and boosting resilience

Voss

2024

Neurogastroenterology Motil

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The enteric nervous system (ENS) orchestrates intricate and autonomous functions throughout the gastrointestinal (GI) tract. Disruptions in ENS function are associated GI disorders. This mini review focuses on the past decade's research, utilizing rodent models, with an emphasis on protecting enteric neurons from loss. The review specifically looks at efforts to reduce oxidative stress, limit inflammation, and enhance neuronal resilience. Protective interventions including administration of antioxidants and compounds targeting cellular redox buffer systems, are evaluated for their effectiveness in preventing loss of enteric neurons in the ischemia–reperfusion model and streptozotocin‐induced diabetes model. Interventions such as engrafting mesenchymal stem cells and targeting inflammatory signaling pathways in enteric neurons and glial cells are evaluated in inflammatory bowel disease models including the Winnie mouse, DSS‐, and DNBS/TNBS‐induced colitis models. The review also touches upon neuronal resilience, particularly in the context of Parkinson's disease models. Including estrogen's neuroprotective role, and the influence of metal ions on enteric neuronal protection. Understanding the dynamic interplay within the ENS and its role in disease pathogenesis holds promise for developing targeted therapies to effectively manage and treat various GI ailments.

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Nicotinamide Riboside Improves Enteric Neuropathy in Streptozocin-Induced Diabetic Rats Through Myenteric Plexus Neuroprotection

Cited by 4 publications

References 34 publications

Nicotinamide Riboside, a Promising Vitamin B3 Derivative for Healthy Aging and Longevity: Current Research and Perspectives

Nicotinamide Riboside, a Promising Vitamin B3 Derivative for Healthy Aging and Longevity: Current Research and Perspectives

Effects of chitosan and its oligosaccharide on gut microbiota and metabolites disturbed by excessive protein consumption in vivo and in vitro

Enteric neuroprotection—A matter of balancing redox potentials, limiting inflammation, and boosting resilience

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