2016
DOI: 10.1016/j.neubiorev.2016.04.003
|View full text |Cite
|
Sign up to set email alerts
|

Nicotine, adolescence, and stress: A review of how stress can modulate the negative consequences of adolescent nicotine abuse

Abstract: In order to continue the decline of smoking prevalence, it is imperative to identify factors that contribute to the development of nicotine and tobacco addiction, such as adolescent initiation of nicotine use, adolescent stress, and their interaction. This review highlights the biological differences between adolescent and adults in nicotine use and resulting effects, and examines the enduring consequences of adolescent nicotine administration. A review of both clinical and preclinical literature indicates tha… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

2
32
0
1

Year Published

2017
2017
2024
2024

Publication Types

Select...
9
1

Relationship

0
10

Authors

Journals

citations
Cited by 57 publications
(35 citation statements)
references
References 140 publications
(175 reference statements)
2
32
0
1
Order By: Relevance
“…Importantly, these two nAChRs have not been directly compared in behavioral sensitization to nicotine when an antagonist was administered each day of nicotine administration as was done in the present study. Furthermore, there have not been any studies that have analyzed the relationship between nAChRs and behavioral sensitization to nicotine exposure in adolescence, so this is the first study to analyze nAChRs during this critical period in which nicotine addiction often begins [58]. The fact that MLA was less effective in NQ animals, but NQ animals in Experiment 2 demonstrated downregulation of α7 nAChRs compared NS-treated rats was somewhat surprising.…”
Section: Discussionmentioning
confidence: 99%
“…Importantly, these two nAChRs have not been directly compared in behavioral sensitization to nicotine when an antagonist was administered each day of nicotine administration as was done in the present study. Furthermore, there have not been any studies that have analyzed the relationship between nAChRs and behavioral sensitization to nicotine exposure in adolescence, so this is the first study to analyze nAChRs during this critical period in which nicotine addiction often begins [58]. The fact that MLA was less effective in NQ animals, but NQ animals in Experiment 2 demonstrated downregulation of α7 nAChRs compared NS-treated rats was somewhat surprising.…”
Section: Discussionmentioning
confidence: 99%
“…Self-medication may apply since nicotine is used to lessen stress and anxiety symptoms. The effects of nicotine on stress are mixed: acute nicotine administration mitigates stress by increasing plasma corticosterone levels whereas chronic nicotine administration alters the adaptive response to chronic stress [8]. In turn, chronic stress may reduce nicotine responsiveness through interactions between persistent elevated plasma corticosterone levels and the dopaminergic system.…”
Section: Comparison With Other Studies and Interpretationmentioning
confidence: 99%
“…11 Psychological and social stress increases the risk of smoking initiation. 12,13 Chronic nicotine exposure has been shown to be associated with the dysregulation of the stress response systems including the hypothalamic-pituitary-adrenal (HPA) axis. 14,15 Tobacco use is associated with elevated baseline cortisol levels, as well as blunted cortisol response to acute stress.…”
Section: Introductionmentioning
confidence: 99%