Nicotine and lipopolysaccharide stimulate the formation of osteoclast-like cells by increasing macrophage colony-stimulating factor and prostaglandin E2 production by osteoblasts

Tanaka, Hideki; Tanabe, Natsuko; Shoji, Maiko; Suzuki, Naoto; Katono, Tomoko; Sato, Setsuko; Motohashi, Masafumi; Maeno, Masao

doi:10.1016/j.lfs.2005.08.017

Cited by 87 publications

(93 citation statements)

References 45 publications

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“…Tanka et al [15] demonstrated that I/p injection of E.coli lipopolysaccharid (LPS) stimulates inflammatory response. The response in turn, caused release of chemical mediators such as macrophage colony stimulating factor which in turn activates various cell systems as macrophage and neutrophils.…”

Section: Resultsmentioning

confidence: 99%

Studies on the Immunomodulatory Effects of Lactoferrin in Rats Infected with E. coli

El‐Boshy¹,

Abdalla²,

Hassan³

2013

JIBTVA

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Eighty male albino rats of Westar strain (350 ± 10 g), 10 to 12 weeks old were divided into four groups. The groups treated are as following. The first control group (Gp. I) was given intraperitoneally in normal saline (1 mL). The second group (Gp. II) was orally infected with 3 × 10 12 CFU of E. coli /Kg. BW. The third group (Gp. III) was infected with E. coli and treated with (0.5%) lactoferrin (LF) 72 hours before E. coli infection in filtered tap water for the duration of the experiment (21 days). The fourth group (Gp. IV) was administrated with LF only (0.5%) in drinking water. Two separate blood samples were collected from heart puncture at the end of 1 st , and 3 rd week post-treatment for immunological studies. The Leukogram in E. coli treated group was insignificant compared with the control group while lymphocytosis was clear compared with the infected group. Total protein, albumin, α-globulin and β-globulin were insignificantly changed in LF & E. coli treatment group comparing with infected and control groups. TNF-α and γ-globulin are significantly increased in infected group comparing with other treated groups. In conclusion, lactoferrin has powerful antibacterial activity in a variety of ways as well as a safe immunostimulant protein when it is orally administrated.

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Section: Resultsmentioning

confidence: 99%

Studies on the Immunomodulatory Effects of Lactoferrin in Rats Infected with E. coli

El‐Boshy¹,

Abdalla²,

Hassan³

2013

JIBTVA

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“…However, Tanaka et al 35 suggested that nicotine stimulates the formation of osteoclast-like cells via an increase in macrophage colony-stimulating factor and PGE 2 production by osteoblasts. This could be confirmed by Shoji et al 36 There are contradictory results in PGE 2 synthetic rate, cigarette smoking and bone loss.…”

Section: Discussionmentioning

confidence: 99%

Influence of cigarette smoking on synthesis of eicosanoids, isoprostanes and lipoxygenase metabolites in apical periodontitis

Eder¹,

Koegl²,

Duvillard

et al. 2012

Archives of Oral Biology

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This file was dowloaded from the institutional repository Brage NIH -brage.bibsys.no/nih Eder, A., Koegl, E,. von Duvillard, S., Sinzinger, H., Berent, R. (2012 Conclusions: Our data demonstrate that in smokers with granuloma due to AP products of lipid peroxidation as 8-iso-PGF 2α and products of the LOX-pathway are increased at the expense of cyclooxygenase products. The size of granuloma did not influence the amount of synthesized eicosanoids, IPs or LOX-metabolites out of 14 C-AA whereas cigarette smoking was a significantly influencing and modifiable risk factor.

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“…Nicotine and lipopolysaccharide (LPS) effects on the expression of macrophage colony-stimulating factor (M-CSF), osteoprotegerin (OPG), and prostaglandin E 2 (PGE 2 ) have been evaluated by Tanaka et al (2006) in osteoblasts and osteoclast-like cells. OPG expression was increased in the initial stages of culture with nicotine and LPS but decreased in the later stages of culture.…”

Section: Introductionmentioning

confidence: 99%

Effects of Tobacco Smoking on Chronic Periodontitis and Periodontal Treatment

Buduneli¹

2012

Pathogenesis and Treatment of Periodontitis

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Nicotine and lipopolysaccharide stimulate the formation of osteoclast-like cells by increasing macrophage colony-stimulating factor and prostaglandin E2 production by osteoblasts

Cited by 87 publications

References 45 publications

Studies on the Immunomodulatory Effects of Lactoferrin in Rats Infected with E. coli

Studies on the Immunomodulatory Effects of Lactoferrin in Rats Infected with E. coli

Influence of cigarette smoking on synthesis of eicosanoids, isoprostanes and lipoxygenase metabolites in apical periodontitis

Effects of Tobacco Smoking on Chronic Periodontitis and Periodontal Treatment

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