Nicotine Dependence: Diagnosis, Chemistry and Pharmacological Treatments

Miller, Jake N.; Cocores, James A.; Belkin, Beth M.

doi:10.3109/10401239109147967

Cited by 12 publications

(2 citation statements)

References 26 publications

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“…Therefore, this evidence suggests that the LMTK3 −/− mice could be exhibiting a behavioural pattern consistent with overlapping bipolar and schizophrenia-like behaviour [ 68 ]. Schizoaffective-like behaviour has a mixture of both mood and psychotic symptoms [ 71 ], and the LMTK3 −/− mice could resemble this disease.…”

Section: The Physiological Function Of Lmtk3mentioning

confidence: 99%

The multifaceted role of lemur tyrosine kinase 3 in health and disease

et al. 2021

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In the last decade, LMTK3 (lemur tyrosine kinase 3) has emerged as an important player in breast cancer, contributing to the advancement of disease and the acquisition of resistance to therapy through a strikingly complex set of mechanisms. Although the knowledge of its physiological function is largely limited to receptor trafficking in neurons, there is mounting evidence that LMTK3 promotes oncogenesis in a wide variety of cancers. Recent studies have broadened our understanding of LMTK3 and demonstrated its importance in numerous signalling pathways, culminating in the identification of a potent and selective LMTK3 inhibitor. Here, we review the roles of LMTK3 in health and disease and discuss how this research may be used to develop novel therapeutics to advance cancer treatment.

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Section: The Physiological Function Of Lmtk3mentioning

confidence: 99%

The multifaceted role of lemur tyrosine kinase 3 in health and disease

et al. 2021

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“…Naturally, nicotine only exists in the S shape and is found in Solanaceae night shade family plants such as Nicotiana rustica, Nicotiana tabacum, Duboisia hopwoodii and Asclepias syriaca [1]. It functions as a potent parasympathomimetic, stimulant drug, antiherbivore chemical, antagonist, nicotinic acetylcholine receptor agonist, insecticide and it is widely used as highly addictive unless used in slow-release forms [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Nicotine metal complexes: synthesis, characterization and bioactivities of some main group and some transition metals

Awwad¹,

Ibrahium²,

Shati³

et al. 2021

Bull. Chem. Soc. Eth.

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A number of some main group and transition metal nicotine complexes were synthesized and fully characterized using detailed structural and spectroscopic analysis techniques such as elemental analysis, molar conductivities, magnetic susceptibilities, IR, Raman and NMR techniques. Moreover, scanning electron micrographs and thermogravimetric analyses were also done. Cytotoxic activities of the binary nicotine metal complexes were tested and evaluated against HepG2 (human hepatocellular carcinoma), HPC3 (human prostate cancer), and HCT116 (human colorectal carcinoma) tumor cell lines. The antioxidant activities were examined by free radical scavenging assay. The antimicrobial activities of the synthesized complexes were evaluated against Escherichia coli (gram-negative) and Staphylococcus aureus (gram-positive) microbes. The relationship between the chemical structure of the synthesized complexes and their biological influence as antimicrobial drugs was studied and evaluated. KEY WORDS: Nicotine metal complexes, Cytotoxicity, Antioxidant, Antimicrobial Bull. Chem. Soc. Ethiop. 2020, 34(3), 501-521. DOI: https://dx.doi.org/10.4314/bcse.v34i3.7

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