Nicotine Dependence in Adolescence and Physical Health Symptoms in Early Adulthood

Griesler, Pamela C.; Hu, Mei‐Chen

doi:10.1093/ntr/ntv149

Cited by 10 publications

(8 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This rate aligns with prior work and is concerning as even intermittent, nondaily use can lead to nicotine dependence, 31,32 which is a strong predictor of physical health symptoms (eg, chest pain) in young adulthood. 33 This study highlights the critical need for adolescent smoking initiation and reduction efforts nationwide.…”

Section: Discussionmentioning

confidence: 90%

Screening, Counseling, and Health Care Utilization Among a National Sample of Adolescent Smokers

Merianos

Mahabee‐Gittens

2020

Clin Pediatr (Phila)

View full text Add to dashboard Cite

Our objective was to assess the association between cigarette smoking and tobacco use screening and advising to quit use by a clinician among adolescents nationwide. We also examined the relationships between smoking and health-related indicators and health care utilization. A secondary analysis of the 2017 National Survey on Drug Use and Health was conducted (N = 11 884). Ever smokers were less likely to be screened for tobacco use. Current smokers and those who were nicotine dependent were more likely to have been advised to quit use. Ever and current smokers were significantly more likely to report good/fair/poor health status, illness-related school absenteeism in the past 30 days, and were more likely to have had an emergency department visit or an overnight hospital stay. Standardized tobacco control efforts are needed in health care settings to support clinicians to screen all adolescents for tobacco use and advise every smoker irrespective of smoking frequency to quit use.

show abstract

Section: Discussionmentioning

confidence: 90%

Screening, Counseling, and Health Care Utilization Among a National Sample of Adolescent Smokers

Merianos

Mahabee‐Gittens

2020

Clin Pediatr (Phila)

View full text Add to dashboard Cite

show abstract

“…Epidemiological and clinical data have shown that exposure to tobacco or nicotine can lead to subsequent abuse of nicotine and other recreational drugs in adolescents, and this phenomenon is described as the gateway hypothesis ( 45 ). Parents can affect the health of their children through genetic factors, physical and mental health, health behaviors and socioeconomic status ( 11 ).…”

Section: Methodsmentioning

confidence: 99%

“…The urge to smoke occurs early on after initiation, which drives the increase in frequency of use, exacerbating into nicotine dependence and a more rapid progression to addiction and a neurophysiologic dependence on nicotine ( 9 ). The risk of nicotine dependence in adolescents is associated with intensity of recent cigarette consumption, a slower nicotine metabolism and depression ( 11 ). The CDC warns that if cigarette smoking continues at the current rate among youth, 5.6 million of Americans younger than 18 will die early from a smoking-related illness ( 12 ).…”

Section: Introductionmentioning

confidence: 99%

Multifactorial Etiology of Adolescent Nicotine Addiction: A Review of the Neurobiology of Nicotine Addiction and Its Implications for Smoking Cessation Pharmacotherapy

Mahajan

Homish

Quisenberry

2021

Front. Public Health

View full text Add to dashboard Cite

Nicotine is the primary pharmacologic component of tobacco, and its highly addictive nature is responsible for its widespread use and significant withdrawal effects that result in challenges to smoking cessation therapeutics. Nicotine addiction often begins in adolescence and this is at least partially attributed to the fact that adolescent brain is most susceptible to the neuro-inflammatory effects of nicotine. There is increasing evidence for the involvement of microglial cells, which are the brain's primary homeostatic sensor, in drug dependence and its associated behavioral manifestations particularly in the adolescent brain. A hallmark of neuro-inflammation is microglial activation and activation of microglia by nicotine during adolescent development, which may result in long-term addiction to nicotine. This non-systematic review examines multifactorial etiology of adolescent nicotine addiction, neurobiology of nicotine addiction and the potential mechanisms that underlie the effects of nicotine on inflammatory signaling in the microglia, understanding how nicotine affects the adolescent brain. We speculate, that modulating homeostatic balance in microglia, could have promising therapeutic potential in withdrawal, tolerance, and abstinence-related neural adaptations in nicotine addiction, in the adolescent brain. Further, we discuss nicotine addiction in the context of the sensitization-homeostasis model which provides a theoretical framework for addressing the potential role of microglial homeostasis in neural adaptations underlying nicotine abuse.

show abstract

“…Nicotine dependence (ND) is characterized by tolerance, craving, withdrawal symptoms in case of abstinence, loss of control over the number of cigarettes and the time spent smoking, unsuccessful attempts to quit, neglect of important activities, and smoking despite physical or psychological problems (Griesler et al 2016). Withdrawal symptoms due to nicotine include but are not limited to depressed mood, irritability, nervousness, anger, anxiety, trouble focusing, and impatience (Griesler et al 2016). The unpublished results of a recent national study conducted among adolescents revealed that the prevalence of moderate to high cigarette dependence was 21.8%.…”

Section: Introductionmentioning

confidence: 99%

Adaptation of the Young Adults’ Cigarette Dependence (YACD) Scale for the development and validation of the Adolescent Cigarette Dependence Scale (ACDS)

Hallit

Obeïd

Sacre³

et al. 2021

Environ Sci Pollut Res

View full text Add to dashboard Cite

Vulnerable adolescents may lose control over cigarette use within a day or two after smoking their first cigarette, as nicotine dependence (ND) symptoms may appear before actual daily smoking and usually occur at low levels of daily smoking. Moreover, smoking can cause illnesses and promote other types of substance abuse. Therefore, it was deemed essential to adapt the Young Adults' Cigarette Dependence (YACD) Scale to develop and validate the Adolescent Cigarette Dependence Scale (ACDS) in Lebanese adolescents and evaluate whether cumulative cigarette smoking is associated with nicotine dependence and symptoms of dependence. A cross-sectional study was carried out between August and September 2020, during the partial sanitary lockdown imposed by the government to limit COVID-19, coinciding with the summer holidays for most Lebanese. The total sample consisted of 564 community-dwelling adolescents aged 13 to 18. A factor analysis was performed using a varimax rotation. The Kaiser-Meyer-Olkin (KMO) measurement of sampling adequacy and Bartlett's sphericity test were appropriate. The factors retained corresponded to Eigenvalues > 1. Cronbach's alpha value represented the internal consistency of the scale. The Hooked on Nicotine Checklist (HONC) was used to screen for dependence symptoms. All items of the YACD were extracted, except for items 4 (smoking to concentrate at work) and 18 (smoking as a habit), which yielded a three-factor solution (factor 1 = smoking patterns; factor 2 = positive and negative reinforcements; factor 3 = smoking cessation) with Eigenvalues > 1 (variance explained = 56.18%; KMO = 0.784; Bartlett's sphericity test p < 0.001; α Cronbach = 0.875). The newly generated scale was termed Adolescent Cigarette Dependence Scale (ACDS) and consisted of 19 items. Higher ACDS scores (higher cigarette dependence) were significantly associated with higher HONC scores (higher symptoms of dependence) (rho = 0.647; p < 0.001). Having deceased (B = 8.54) or divorced (B = 4.26) parents and higher cumulative cigarette smoking (B = 0.29) were significantly associated with higher ACDS scores. Higher cumulative cigarette smoking (B = 0.05) was significantly associated with higher HONC scores due to cigarettes. This study could validate a new tool to evaluate nicotine dependence among Lebanese adolescents, the Adolescent Cigarette Dependence Scale (ACDS). This version adapted from the Young Adults' Cigarette Dependence (YACD) Scale is reliable and valuable and correlates well with other scales, such as the HONC. However, further studies are necessary to improve this instrument, adding new questions useful for the diagnosis and evaluation of cigarette dependence.

show abstract

Nicotine Dependence in Adolescence and Physical Health Symptoms in Early Adulthood

Cited by 10 publications

References 44 publications

Screening, Counseling, and Health Care Utilization Among a National Sample of Adolescent Smokers

Screening, Counseling, and Health Care Utilization Among a National Sample of Adolescent Smokers

Multifactorial Etiology of Adolescent Nicotine Addiction: A Review of the Neurobiology of Nicotine Addiction and Its Implications for Smoking Cessation Pharmacotherapy

Adaptation of the Young Adults’ Cigarette Dependence (YACD) Scale for the development and validation of the Adolescent Cigarette Dependence Scale (ACDS)

Contact Info

Product

Resources

About