Nicotine-induced locomotor activity is increased by preexposure of rats to prenatal stress

Koehl, Muriel; Bjijou, Y; Moal, Michel Le; Cador, Martine

doi:10.1016/s0006-8993(00)02803-1

Cited by 49 publications

(17 citation statements)

References 32 publications

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“…stereotypies), and decreased exploration, locomotion and play behaviour [6,[150][151][152]. In contrast, other studies have demonstrated an association of prenatal stress with increased locomotor activity and rearing in open-field and plus-maze tests in adult rat offspring [141,[153][154][155][156]. Thus, it is unclear if increased locomotion in the open-field can be interpreted as a measure of reduced anxiety or as psychomotor hyperactivity.…”

Section: Anxiety Behaviourmentioning

confidence: 99%

RETRACTED: Maternal adversity, glucocorticoids and programming of neuroendocrine function and behaviour

Owen

Andrews

Matthews

2005

Neuroscience & Biobehavioral Reviews

196

148

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Section: Anxiety Behaviourmentioning

confidence: 99%

RETRACTED: Maternal adversity, glucocorticoids and programming of neuroendocrine function and behaviour

Owen

Andrews

Matthews

2005

Neuroscience & Biobehavioral Reviews

196

148

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“…Several studies have revealed that PNS heightens the response to, and/or seeking of, stimulant drugs. Enhanced psychomotor activation in response to stimulants occurs in adult PNS male rats following challenge with amphetamine (Deminiere et al, 1992), cocaine (Kippin et al, 2008), or nicotine (Koehl et al, 2000), as well as in adolescent females (males were not examined in this report) following challenge with methylenedioxymethamphetamine (Morley-Fletcher et al, 2004). Further, greater behavioral sensitization has been observed in adult PNS males following repeated amphetamine injections (Henry et al, 1995) and in adult PNS females, but not males, following repeated cocaine injections (Thomas et al, 2009).…”

Section: Impact Of Prenatal Stress On Animal Models Of Addiction and mentioning

confidence: 89%

Prenatal Stress Alters Progestogens to Mediate Susceptibility to Sex-Typical, Stress-Sensitive Disorders, such as Drug Abuse: A Review

et al. 2011

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Maternal–offspring interactions begin prior to birth. Experiences of the mother during gestation play a powerful role in determining the developmental programming of the central nervous system. In particular, stress during gestation alters developmental programming of the offspring resulting in susceptibility to sex-typical and stress-sensitive neurodevelopmental, neuropsychiatric, and neurodegenerative disorders. However, neither these effects, nor the underlying mechanisms, are well understood. Our hypothesis is that allopregnanolone, during gestation, plays a particularly vital role in mitigating effects of stress on the developing fetus and may mediate, in part, alterations apparent throughout the lifespan. Specifically, altered balance between glucocorticoids and progestogens during critical periods of development (stemming from psychological, immunological, and/or endocrinological stressors during gestation) may permanently influence behavior, brain morphology, and/or neuroendocrine-sensitive processes. 5α-reduced progestogens are integral in the developmental programming of sex-typical, stress-sensitive, and/or disorder-relevant phenotypes. Prenatal stress (PNS) may alter these responses and dysregulate allopregnanolone and its normative effects on stress axis function. As an example of a neurodevelopmental, neuropsychiatric, and/or neurodegenerative process, this review focuses on responsiveness to drugs of abuse, which is sensitive to PNS and progestogen milieu. This review explores the notion that allopregnanolone may effect, or be influenced by, PNS, with consequences for neurodevelopmental-, neuropsychiatric-, and/or neurodegenerative- relevant processes, such as addiction.

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“…The nicotine-induced “structural” alterations in the brain, noted above, correlate with neurobehavioral/cognitive “functional” deficits in exposed animals which mimic deficits seen in children whose mothers smoked during pregnancy (Cornelius and Day 2000; DiFranza et al 2004; Ernst et al 2001) including: increased locomotor activity (Fung 1988; Koehl et al 2000; Nagahara and Handa 1999; Shacka et al 1997), hyperactivity (Ajarem and Ahmad 1998; Newman et al 1999; Sobrian et al 2003; Vaglenova et al 2004), impulsivity (Sobrian et al 2003), and anxiety (Vaglenova et al 2004). In addition, long-term impairments in attention, learning, and memory in smoke exposed animals have been observed through the aid of various paradigms such as, avoidance acquisition (Genedani et al 1983; Peters and Ngan 1982; Vaglenova et al 2004), radial arm maze tasks (Levin et al 1993; Sorenson et al 1991), and operant learning behaviors (Martin and Becker 1971).…”

Section: Introductionmentioning

confidence: 96%

Developmental cigarette smoke exposure: Hippocampus proteome and metabolome profiles in low birth weight pups

et al. 2014

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Exposure to cigarette smoke during development is linked to neurodevelopmental delays and cognitive impairment including impulsivity, attention deficit disorder, and lower IQ. However, brain region specific biomolecular alterations induced by developmental cigarette smoke exposure (CSE) remain largely unexplored. In the current molecular phenotyping study, a mouse model of ‘active’ developmental CSE (serum cotinine>50 ng/mL) spanning pre-implantation through third trimester-equivalent brain development (gestational day (GD) 1 through postnatal day (PD) 21) was utilized. Hippocampus tissue collected at the time of cessation of exposure was processed for gel-based proteomic and non-targeted metabolomic profiling with Partial Least Squares-Discriminant Analysis (PLS-DA) for selection of features of interest. Ingenuity Pathway Analysis was utilized to identify candidate molecular and metabolic pathways impacted within the hippocampus. CSE impacted glycolysis, oxidative phosphorylation, fatty acid metabolism, and neurodevelopment pathways within the developing hippocampus.

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Nicotine-induced locomotor activity is increased by preexposure of rats to prenatal stress

Cited by 49 publications

References 32 publications

RETRACTED: Maternal adversity, glucocorticoids and programming of neuroendocrine function and behaviour

RETRACTED: Maternal adversity, glucocorticoids and programming of neuroendocrine function and behaviour

Prenatal Stress Alters Progestogens to Mediate Susceptibility to Sex-Typical, Stress-Sensitive Disorders, such as Drug Abuse: A Review

Developmental cigarette smoke exposure: Hippocampus proteome and metabolome profiles in low birth weight pups

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