Nicotinic modulation of gene expression in osteoblast cells, MG-63

Altered ultrastructure, density and cathepsin K expression in bone of female muscarinic acetylcholine receptor M3 knockout mice

“…Several cholinergic receptors, transporters, and enzymes were identified in bone forming osteoblasts as well as in bone resorbing osteoclasts [4,5,13]. Acetylcholine and the exogenous ligand nicotine are involved in proliferation of osteoprogenitors and their differentiation into active osteoblasts [13][14][15]. However, cholinergic markers in the non-neuronal system seemed to be reduced in osteoporosis.…”

Factors affecting the incidence of aseptic nonunion after surgical fixation of humeral diaphyseal fracture

“…Many studies have revealed that smoking, and nicotine in particular, has direct, detrimental effects on the health of bone and its ability to heal itself [11][12][13][14][15]. Cigarette smoking has been shown to interfere with bone formation, metabolism, and revascularization [14,15].…”

Drugs of abuse and addiction: A slippery slope toward liver injury

“…Nicotine exposure affects osteoblast proliferation, metabolism, extracellular matrix formation and growth factor signalling cascade including FGF-1, FGF-2, and RUNX2 [90,91]. Interestingly, using hepatic cell line HepaRG, it has been demonstrated that nicotine administration leads to dose-dependent reduction in NNK-induced DNA double strand break [92].…”

“…Curcumin and its analog has modulatory activity on circulatory lipid profile in rats having nicotine-induced toxicity [106]. Melatonin, quercetin and hesperidin alleviated the effect of nicotine toxicity to liver [90][91][92][93][94]. Gender may also be a critical factor that could indicate the level of oxidative stress after nicotine exposure [107].…”