Nigella sativa L. as immunomodulator and preventive effect on renal tissue damage of lupus mice induced by pristane

Hikmah, Zahrah; Endaryanto, Anang; Ugrasena, I Dewa Gede; Rahaju, Anny Setijo; Arifin, Syaiful

doi:10.1016/j.heliyon.2022.e09242

Cited by 12 publications

(8 citation statements)

References 43 publications

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“…For mothers who give birth more than once, breast milk production is much higher than for mothers who give birth for the first time. The number of deliveries that the mother has undergone affects their baby experience (Hikmah et al, 2022).…”

Section: Resultsmentioning

confidence: 99%

The Effect of Black Cumin (Nigella Sativa) on Breastfeeding Mothers

Zakaria

Astuti

2022

j. info kesehat.

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Breast milk is the best nutrient to reduce the pain in nursing mothers and death in infants. However, for nursing mothers, too little milk volume is the cause of problems occurring during the breastfeeding process. Thus, mothers who breastfeed should consume foods that can increase the breast milk volume. One food frequently consumed by mothers to increase breast milk is honey. In fact, natural honey is challenging to discover, and the price is also high which makes it as an obstacle. A more economical alternative is required, one of which is black cumin. It is easy to obtain and the price is also affordable. Black cumin also contains galactagogue to increase prolactin that influences breast milk production. The objective of this study is to identify the effect of black cumin on the volume of breast milk. The study was a randomized controlled trial involving 60 breastfeeding mothers divided into intervention groups and control groups. The intervention group was provided 15 grams of black cumin brewed with 1000C boiling water as much as 200 ml, and the control group was assigned 15 grams of pure honey brewed boiling 1000C as much as 200 ml. Intervention and control were administered on the second day to the day of completion after giving birth. They were measuring instruments which accustomed to measure breast milk pumps. Bivariate analysis employing the Wilcoxon and Mann Whitney tests presented a significant difference between the volume of breast milk (p = 0.001) of the control and intervention groups. This study recommends the application of black cumin as a strategy to increase the volume of breast milk in nursing mothers.

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Section: Resultsmentioning

confidence: 99%

The Effect of Black Cumin (Nigella Sativa) on Breastfeeding Mothers

Zakaria

Astuti

2022

j. info kesehat.

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“…Methyl salicylate 2-O-β-D-lactoside-salicylic acid analogue extracted from the herbal medicine Gaultheria yunnanensis and coptisine, alkaloid in the dried rhizome of Coptis chinensis, have been previously reported to ameliorate lupus-like disease in pristine-treated mice [27,28]. Nigella sativa L. used in traditional Indonesian medicine, Baicalein-flavonoid derived from the roots of the herbal medicine Scutellaria baicalensis Georgi and 3β-acetyloxyoleanolic acid, isolated from the root of Symplocos laurina, also showed an anti-inflammatory and protective effect on the development of lupus nephritis in this murine model [29,30]. Other substances, such as tofacitinib and melatonin, also alleviated the progression of pristane-induced lupus [31][32][33].…”

Section: Discussionmentioning

confidence: 99%

Methyl‐supplemented nutrition delays the development of autoimmune disease in pristane‐induced murine lupus

Bradyanova,

Manoylov,

Boneva

et al. 2024

Immunology

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The aetiology and progression of systemic lupus erythematosus (SLE) resulted from a complex sequence of events generated both from genetic and epigenetic processes. In the current research, the effect of methyl‐supplemented nutrition on the development of SLE was studied in the pristane‐induced mouse model of the disease. The results clearly demonstrated decreased anti‐dsDNA antibody and proteinuria levels, modulation of cytokines and protected renal structures in the group of treated mice. An additional increase in the DNA methylation of mouse B lymphocytes was also observed. The beneficial effect of the diet is due to the methyl‐containing micronutrients with possible anti‐inflammatory and immunomodulating effects on cell proliferation and gene expression. Since these components are responsible for maintaining the physiological methylation level of DNA, the results point to the central role of methylation processes in environmentally triggered lupus. As nutrition represents one of the major epigenetic factors, these micronutrients may be considered novel agents with significant therapeutic outcomes.

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“…An in vitro study conducted by Ciesielska-Figlon and coauthors [20] reported the immunomodulatory effect of N. sativa seed oil by inhibiting proliferation and inducing apoptosis of human T lymphocytes. In another study, N. sativa ethanol extract showed renoprotective and immunomodulatory effects in mice by suppressing the pro-inflammatory cytokines [21]. Furthermore, antioxidant activity of N. sativa promisingly inhibited the oxidative stress-mediated hepatic damage [22].…”

Section: Introductionmentioning

confidence: 94%

Nigella sativa L. Attenuates Oxidative Stress, Inflammation and Apoptosis in Concanavalin A-induced Acute Immunological Liver Damage in Mice

Mushtaq,

Aslam,

Faisal

et al. 2024

Braz. arch. biol. technol.

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Liver's contribution to innate immunity is eminent. However, uncontrolled inflammatory conditions predispose the liver to immune-mediated injury. Nigella sativa L. is traditionally implicated in infectious, inflammatory, metabolic and hepatorenal complications. This study aimed to evaluate the protective role of N. sativa seed extract (NSE) against concanavalin A (ConA)-induced acute immunological liver injury in mice. In vitro, NSE was subjected to quantitative phytochemical characterization and 1,1-diphenyl-2-picryhydrazyl (DPPH) analysis. In vivo, male Balb/c mice were pretreated with NSE (100, 200 and 400 mg/kg/day, p.o.) and pioglitazone (5 mg/kg/day, p.o.) for seven consecutive days. A single dose of ConA (12 mg/kg, i.v.) was injected and samples were collected for biochemical, histopathological and qRT-PCR analyses after 8 h of ConA injection. In vitro analysis showed considerable quantities of polyphenols and significant DPPH scavenging ability of NSE. In mice, ConA resulted in a significant (p<0.05) increase in liver injury markers (ALT, AST, ALP and TBil) and hepatic oxidative stress (SOD, CAT and MDA). Also, a substantial elevation of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) in liver tissues was noticed. Furthermore, ConA HIGHLIGHTS• Nigella sativa seed extract (NSE) possess significant polyphenol contents and antioxidant potential.• NSE attenuated concanavalin A-induced liver injury and oxidative stress.• NSE suppressed liver inflammation through modulating PPARγ/JAK2/STAT3 pathway.• NSE inhibited hepatocyte apoptosis via downregulating Bcl-2/Bax/Caspase-9 pathway.

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Nigella sativa L. as immunomodulator and preventive effect on renal tissue damage of lupus mice induced by pristane

Cited by 12 publications

References 43 publications

The Effect of Black Cumin (Nigella Sativa) on Breastfeeding Mothers

The Effect of Black Cumin (Nigella Sativa) on Breastfeeding Mothers

Methyl‐supplemented nutrition delays the development of autoimmune disease in pristane‐induced murine lupus

Nigella sativa L. Attenuates Oxidative Stress, Inflammation and Apoptosis in Concanavalin A-induced Acute Immunological Liver Damage in Mice

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