Nigella sativa L. for prevention of acute radiation dermatitis in breast cancer: A randomized, double-blind, placebo-controlled, clinical trial

Rafati, Mohammadreza; Ghasemi, Arash; Saeedi, Majid; Habibi, Emran; Salehifar, Ebrahim; Mosazadeh, Mahmood; Maham, Monireh

doi:10.1016/j.ctim.2019.102205

Cited by 39 publications

(37 citation statements)

References 27 publications

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“…The main mechanism of RT-induced proctitis is DNA damage and cell death which trigger the in ammatory responses following exposure to radiation (16). Previous studies indicated that anti-in ammatory agents can decrease the severity of ARP partly by reducing in ammation (17,18).…”

Section: Discussionmentioning

confidence: 99%

Aloe vera for Prevention of Acute Radiation Proctitis in Colorectal Cancer a Preliminary Randomized, Placebo-Controlled Clinical Trial

Sahebnasagh

Saghafi

Ghasemi

et al. 2021

J Gastrointest Canc

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Background Acute radiation proctitis (ARP) is a common complication of radiation therapy (RT). This adverse effect in severe cases ultimately results in interruption of RT and poor outcome. Aloe vera contains multiple antioxidant and anti-in ammatory compounds This study was aimed to evaluate the preventive effects of Aloe vera in ARP in colorectal cancer. Method: twenty eligible colorectal cancer patients, who received radiation, were randomized to receive Aloe vera 3% ointment or placebo for six weeks. At each weekly visit, ARP symptoms were evaluated by Radiation Therapy Oncology Group (RTOG) and clinical presentation criteria. The lifestyle impact of the symptoms, depression and anxiety for assessment of psychosocial status of patients, and quantitative CRP were evaluated as secondary endpoints. Results there was a signi cant improvement in the symptom index for diarrhea and total RTOG scores and quantitative CRP levels (between-subject differences or group effect) (p < 0.05) in Aloe group. The overall time trend (within-subject differences or time effect) was statistically signi cant for rectal bleeding, rectal pain, total clinical scores, proctitis, cystitis, and total RTOG (P < 0.05) in Aloe vera group. The median lifestyle score improved signi cantly with Aloe vera. Intervention patients had a lower probability of presenting anxiety in their overall HAD scale during RT. Conclusion The use of topical formulation of Aloe vera 3% diminished the severity of ARP in colorectal cancer patients. Trial registration: Current Controlled Trials IRCT201606042027N6, registrations date: 2016-04-09.

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Section: Discussionmentioning

confidence: 99%

Aloe vera for Prevention of Acute Radiation Proctitis in Colorectal Cancer a Preliminary Randomized, Placebo-Controlled Clinical Trial

Sahebnasagh

Saghafi

Ghasemi

et al. 2021

J Gastrointest Canc

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“…sativa L. (black seed) has been used primarily as a traditional medicine for a variety of diseases, including skin diseases, bronchial asthma, gastrointestinal disorders, toothache, diabetes mellitus, hypertension, etc. [76][77][78], for more than 2000 yr (16).…”

Section: N Sativa (Black Seed) and Zinc (Zn)mentioning

confidence: 99%

Perspective Adjunctive Therapies for COVID-19: Beyond Antiviral Therapy

Ho¹,

Zheng²,

Wu³

et al. 2021

Int. J. Med. Sci.

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The coronavirus disease 2019 (COVID-19) pandemic is the largest health crisis ever faced worldwide. It has resulted in great health and economic costs because no effective treatment is currently available. Since infected persons vary in presentation from healthy asymptomatic mild symptoms to those who need intensive care support and eventually succumb to the disease, this illness is considered to depend primarily on individual immunity. Demographic distribution and disease severity in several regions of the world vary; therefore, it is believed that natural inherent immunity provided through dietary sources and traditional medicines could play an important role in infection prevention and disease progression. People can boost their immunity to prevent them from infection after COVID-19 exposure and can reduce their inflammatory reactions to protect their organ deterioration in case suffering from the disease. Some drugs with in-situ immunomodulatory and anti-inflammatory activity are also identified as adjunctive therapy in the COVID-19 era. This review discusses the importance of COVID-19 interactions with immune cells and inflammatory cells; and further emphasizes the possible pathways related with traditional herbs, medications and nutritional products. We believe that such pathophysiological pathway approach treatment is rational and important for future development of new therapeutic agents for prevention or cure of COVID-19 infection.

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“…No side effects nor anti-cancer effects were observed at this dosage [ 273 ]. In a randomized, double-blind, placebo-controlled clinical trial comprising 62 breast cancer patients undergoing radiotherapy, Nigella sativa 5% gel significantly reduced the severity of acute radiation dermatitis and delays the onset of moist desquamation [ 97 ] ( Table 3 ). The pharmacokinetic characteristics of thymoquinone such as high lipophilicity, poor solubility and low bioavailability limit its use in humans [ 274 ].…”

Section: Black Cumin ( Nigella Sativa )mentioning

confidence: 99%

Medicinal Herbs Used in Traditional Management of Breast Cancer: Mechanisms of Action

et al. 2020

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Background: Breast cancer is one of the principal causes of death among women and there is a pressing need to develop novel and effective anti-cancer agents. Natural plant products have shown promising results as anti-cancer agents. Their effectiveness is reported as decreased toxicity in usage, along with safety and less recurrent resistances compared with hormonal targeting anti-cancer agents. Methods: A literature search was conducted for all English-language literature published prior to June 2020. The search was conducted using electronic databases, including PubMed, Embase, Web of Science, and Cochrane Library. The search strategy included keywords such as breast cancer, herbs, anti-cancer biologically active components, clinical research, chemotherapy drugs amongst others. Results: The literature provides documented evidence of the chemo-preventative and chemotherapeutic properties of Ginseng, garlic (Allium sativum), Black cohosh (Actaea racemose), Tumeric (Curcuma longa), Camellia sinenis (green tea), Echinacea, Arctium (burdock), Flaxseed (Linum usitatissimum) and Black Cumin (Nigella sativa). Conclusions: The nine herbs displayed anti-cancer properties and their outcomes and mechanisms of action include inhibition of cell proliferation, angiogenesis and apoptosis as well as modulation of key intracellular pathways. However, more clinical trials and cohort human studies should be conducted to provide key evidence of their medical benefits.

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Nigella sativa L. for prevention of acute radiation dermatitis in breast cancer: A randomized, double-blind, placebo-controlled, clinical trial

Cited by 39 publications

References 27 publications

Aloe vera for Prevention of Acute Radiation Proctitis in Colorectal Cancer a Preliminary Randomized, Placebo-Controlled Clinical Trial

Aloe vera for Prevention of Acute Radiation Proctitis in Colorectal Cancer a Preliminary Randomized, Placebo-Controlled Clinical Trial

Perspective Adjunctive Therapies for COVID-19: Beyond Antiviral Therapy

Medicinal Herbs Used in Traditional Management of Breast Cancer: Mechanisms of Action

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