Nigella sativa oil modulates the therapeutic efficacy of mesenchymal stem cells against liver injury in irradiated rats

Radwan, Rasha R.; Mohamed, Heba A.

doi:10.1016/j.jphotobiol.2017.11.037

Cited by 29 publications

(32 citation statements)

References 47 publications

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“…3. These results are supported by previous findings of [20] who reported that irradiation induced a significant depletion in SOD activity associated by a distinct elevation in MDA content, which indicates the extent of lipid peroxidation in liver tissues.…”

Section: Resultssupporting

confidence: 91%

Prophylactic Effect of Opuntia ficus indica Fruit Peel Extract against Irradiation-Induced Colon Injury in Rats

et al. 2019

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Opuntia ficus-indica extract has been used in traditional folk medicine for several purposes and exhibits anti-inflammatory properties. This study was directed to explore the prophylactic effect of O. ficus-indica fruit peel extract against irradiation-induced colitis in rats. GC/MS analysis of the petroleum ether extract led to recognition of 33 compounds in the unsaponifiable fraction and 15 fatty acid methyl esters in the saponifiable part. Thirteen terpenes and sterols were isolated and identified from which ten compounds were not isolated from any part of this species before. Data showed that irradiation induced colon injury as manifested by elevated contents of malondialdehyde, nitric oxide, myeloperoxidase, intercellular adhesion molecule-1, cyclooxygenase-2, tumor necrosis factor alpha, and nuclear factor kappa B, while it reduced superoxide dismutase activity and interleukin 10 content in colonic tissues, which was confirmed by histopathological examination. Pretreatment with O. ficus-indica extract attenuated the alteration in the measured parameters. It could be concluded that O. ficus-indica fruit peel extract can be regarded as a potential agent in limiting colonic complications due to irradiation, possibly by its antioxidant and anti-inflammatory properties.

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Section: Resultssupporting

confidence: 91%

Prophylactic Effect of Opuntia ficus indica Fruit Peel Extract against Irradiation-Induced Colon Injury in Rats

et al. 2019

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“…As seen, irradiation causes damage of more than one tissue. Being a radiosensitive organ, the liver has higher susceptibility against radiation damage (Radwan and Mohamed 2018). This is verified by the increase in MDA in the liver which was 3-fold compared to the kidney and brain (2-folds).…”

Section: Discussionmentioning

confidence: 89%

“…Increased MDA levels indicate the activation of lipid peroxidation as a result of the reaction of ROS with unsaturated free fatty acids of membrane lipids. It is known that exposure to irradiation induces liver damage (El-Gazzar et al 2016;Khattab et al 2017;Ashry et al 2017;Radwan and Mohamed 2018;). It is also reported that γ-radiation causes multiple organ dysfunction especially in the liver and an increase of MDA levels in various tissues depending on the time and dose (Simsek et al 2012;Tawfik et al 2013;Xie et al 2014;El-Gazzar et al 2016).…”

Section: Discussionmentioning

confidence: 99%

“…Radiation is widely used for radiotherapy, medical diagnosis, dental radiography and several imaging protocols. Its exposure is also in question in accidental radiation releases (Radwan and Mohamed 2018). It has been determined that ionizing radiation causes oxidative stress by generating various reactive oxygen species (ROS) molecules such as superoxide, singlet oxygen, and hydrogen peroxide that have the potential to damage critical cellular elements like DNA, proteins, and membrane lipids and consequently lead to physical and chemical damage in cells, resulting in cell death (Koc et al 2003).…”

mentioning

confidence: 99%

“…In liver cancer, hepatic radiotherapy causes irradiation-associated liver damage which can be life-threatening (Radwan and Mohamed 2018). Cancer radiotherapy and accidental exposure to ionizing radiation require new safe and effective radioprotective agents for the purpose of treating the damage to normal tissue induced by exposure to ionizing radiation.…”

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confidence: 99%

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The effect of curcumin on lipid peroxidation and selected antioxidants in irradiated rats

Özçelik

Erişir

Güler³

et al. 2018

Acta Vet. Brno

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The effect of irradiation on oxidants and antioxidants in selected tissues and a possible protective effect of curcumin on these indices were investigated. A total of 28 rats were divided into 3 groups; group 1 was control; group 2 was the irradiation group, saline was administered intraperiotenally (i.p.) for three days and then, 9 Gy gamma irradiation was applied; group 3 was the irradiation + curcumin group: curcumin was given i.p. for three days at 200 mg/kg body weight and then the same dose of irradiation was applied. A significant increase in malondialdehyde (MDA) was detected in the liver, kidney, and brain tissues of the rats as a result of irradiation (P < 0.01). Glutathione peroxidase (GSH-Px) activity in all the tissues (except for kidneys) decreased (P < 0.01), liver SOD (superoxide dismutase) activity decreased (P < 0.05), and GSH (glutathione) levels in kidney and ovary tissues (P < 0.001) significantly increased. While curcumin administration returned the increased MDA levels in the kidneys and brain in result of irradiation to normal (P < 0.01), it did not return the increased MDA levels in the liver tissue to normal (P < 0.001) despite significantly reducing them. While decreased GSH-Px and SOD activity in the liver in result of irradiation increased with the addition of curcumin (P < 0.05), increased GSH levels in the kidneys and ovaries returned to control levels (P < 0.001). When MDA values were examined, it was found that the addition of curcumin protected the liver, kidneys and brain from the oxidative damage caused by irradiation.

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Structural Diversity, Spectral Data, and Pharmacological Effects of Genus Nigella

Luan Nguyen,

Anam,

Hofdey Megbes

et al. 2023

Chemistry & Biodiversity

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Nigella is one of the most studied plants because of its pharmacological properties like anti-parasitic, anti-inflammatory, neuro-protective, hepatoprotective, and anti-cancerous. In this study, about 20 species of the genus Nigella were reviewed and among them, N. damascene, N. glandulifera, and N. sativa are widely studied for their phytochemical and pharmacological effects. This review describes the phytochemical composition of the genus Nigella, which constitutes many of the compounds including alkaloids, flavonoids, saponins, and terpenoids. The extracts produced by using different solvents and the isolated compounds displayed a wide range of biological activity. These compounds were identified by different spectral techniques. The spectral detail of some advanced techniques including EIS-MS, UV/VIS, IR, 13 C-NMR, and 1 H-NMR of some important phytoconstituents of Nigella spp. has been compiled for the first time in this review which will be helpful to explore and further investigate the chemical composition of this genus.

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Nigella sativa oil modulates the therapeutic efficacy of mesenchymal stem cells against liver injury in irradiated rats

Cited by 29 publications

References 47 publications

Prophylactic Effect of Opuntia ficus indica Fruit Peel Extract against Irradiation-Induced Colon Injury in Rats

Prophylactic Effect of Opuntia ficus indica Fruit Peel Extract against Irradiation-Induced Colon Injury in Rats

The effect of curcumin on lipid peroxidation and selected antioxidants in irradiated rats

Structural Diversity, Spectral Data, and Pharmacological Effects of Genus Nigella

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