Nigella Sativa Oil Protects the Rat Ovary from Oxidative Injury Due to Ischemia-Reperfusion

Atasever, Melahat; Bakacak, Zeyneb

doi:10.12659/msm.905356

Cited by 7 publications

(12 citation statements)

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“…Ovarian torsion is one of the reasons of acute abdomen requiring immediate surgical intervention. 1 Ovarian torsion is observed in approximately 2.5-7.4% of the cases operated due to pelvic pain. 1,2 Torsion occurs with ovary's total or partial rotation around its own axis.…”

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confidence: 99%

“…1 Ovarian torsion is observed in approximately 2.5-7.4% of the cases operated due to pelvic pain. 1,2 Torsion occurs with ovary's total or partial rotation around its own axis. Although it is mostly seen among the women in reproductive period, it can also be observed in all age groups.…”

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confidence: 99%

“…3 Early diagnosis and treatment are important for preservation of ovary and reproductive health. 1,2 However, the diagnosis of torsion in early stages is rather difficult, and imaging methods may not always help. 4 It has been reported that while only 38% of cases have been diagnosed correctly before surgical operation, the cases operated immediately for presumed torsion have been misdiagnosed at such a high rate of 56%.…”

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confidence: 99%

“…Finally, necrosis in ovary starts with the deterioration of arterial blood flow. 1,3 Free oxygen radicals are produced during the ischemia period. 3 These oxygen radicals have also been shown to be related to pathogenesis of many diseases.…”

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“…3 These oxygen radicals have also been shown to be related to pathogenesis of many diseases. 1 The free radicals occurring in case of disease or ischemia can cause oxidation of disulphides and may deteriorate thioldisulphide homeostasis. Moreover, free radicals can be reduced by thiol groups as thiol groups can take on an antioxidant function.…”

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Thiol-Disulphide Homeostasis in Ovarian Torsion-Detorsion: An Experimental Rat Model

Avcı¹,

Huyut²,

Altındağ³

et al. 2020

J Clin Obstet Gynecol

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Ovarian torsion is one of the reasons of acute abdomen requiring immediate surgical intervention. There is not any reliable method for its diagnosis. Delay in treatment may result in loss of ovary. In this study, the purpose is to evaluate efficiency of thioldisulphide homeostasis in early diagnosis of ovarian torsion in experimental rat model and in its follow-up care with biochemical and histopathological findings. Material and Methods: In the study, 24 Albino Wistar female rats were divided into three groups. The first group was the sham group. The second group was the torsion group. The last group was the torsion-detorsion group. Histopathological evaluation was carried out in ovaries in all groups, and values of thiol/disulphide homeostasis were measured in serum samples biochemically. Results: Values of native thiol and total thiol were lower in the torsion-detorsion group compared to the other groups. However, there was no significant difference between of native thiol and total thiol levels in the sham and torsion groups. Interestingly, the index of native thiol/total thiol was relatively low in the torsion and torsion-detorsion groups compared to the sham group. However, this decrease was not significant. Conclusion: These results suggest that native thiol/total thiol values may not be useful for early diagnosis of ovarian torsion but it may be used for follow-up care after detorsion

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