Nigerian antimalarial plants and their anticancer potential: A review

Adewole, Kayode Ezekiel

doi:10.1016/j.joim.2020.01.001

Cited by 25 publications

(11 citation statements)

References 240 publications

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“…Some natural compounds from plants and marine organisms have promising applications as anticancer agents ( Lichota and Gwozdzinski 2018 ). Traditionally, medicinal plants have been used for treating cancer in different parts of the world ( Abubakar et al, 2020 ; Adewole 2020 ). Medicinal plants belonging to Z. species and their phytochemicals with anticancer properties are discussed below.…”

Section: Zanthoxylum Species As Potential Sources Of Anticancer Agentsmentioning

confidence: 99%

“…In Kanayatn Dayak Community, West Kalimantan, Indonesia, the stem and root of Z. bungeanum are consumed raw or after boiling in water to prevent alcohol intoxication and treat respiratory diseases (Sepsamli and Prihastanti 2019). Other traditional and ethnobotanical uses of Z. species have been discussed elsewhere (Patiño et al, 2012;Adewole 2020;Lu et al, 2020a;Obakiro et al, 2020;Okagu et al, 2021). The objectives of this review are to discuss (1) the potential of Z. species as sources of bioactive phytochemicals that can be applied in the management and treatment of cancer, microbial and parasitic infections, and sickle cell disease; (2) chemical constituents involved in these biological activities; and (3) safety issues and suggestions for conservation of the plant species.…”

Section: Introductionmentioning

confidence: 99%

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Zanthoxylum Species: A Review of Traditional Uses, Phytochemistry and Pharmacology in Relation to Cancer, Infectious Diseases and Sickle Cell Anemia

et al. 2021

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The health benefits and toxicity of plant products are largely dependent on their secondary metabolite contents. These compounds are biosynthesized by plants as protection mechanisms against environmental factors and infectious agents. This review discusses the traditional uses, phytochemical constituents and health benefits of plant species in genus Zanthoxylum with a focus on cancer, microbial and parasitic infections, and sickle cell disease as reported in articles published from 1970 to 2021 in peer-reviewed journals and indexed in major scientific databases. Generally, Z. species are widely distributed in Asia, America and Africa, where they are used as food and for disease treatment. Several compounds belonging to alkaloids, flavonoids, terpenoids, and lignans, among others have been isolated from Z. species. This review discusses the biological activities reported for the plant species and their phytochemicals, including anticancer, antibacterial, antifungal, antiviral, anti-trypanosomal, antimalarial and anti-sickling properties. The safety profiles and suggestions for conservation of the Z. species were also discussed. Taken together, this review demonstrates that Z. species are rich in a wide range of bioactive phytochemicals with multiple health benefits, but more research is needed towards their practical application in the development of functional foods, nutraceuticals and lead compounds for new drugs.

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Section: Zanthoxylum Species As Potential Sources Of Anticancer Agentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Zanthoxylum Species: A Review of Traditional Uses, Phytochemistry and Pharmacology in Relation to Cancer, Infectious Diseases and Sickle Cell Anemia

et al. 2021

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“…Hepatic endothelial cell–mediated angiogenesis plays an important role that it not only provides oxygen but also helps the HCC cells escape to a new organ ( Adewole, 2020 ; Shang et al, 2020 ). In a hypoxic microenvironment, HCC cells may switch to anaerobic metabolism, create a more aggressive phenotype, and influence the stroma cells.…”

Section: Discussionmentioning

confidence: 99%

UDCA Inhibits Hypoxic Hepatocellular Carcinoma Cell–Induced Angiogenesis Through Suppressing HIF-1α/VEGF/IL-8 Intercellular Signaling

Lin

Huang

et al. 2021

Front. Pharmacol.

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Background: A hypoxic microenvironment may induce angiogenesis and promote the development of hepatocellular carcinoma (HCC). The aim of this study was to evaluate whether ursodeoxycholic acid (UDCA) may inhibit hypoxic HCC cell–induced angiogenesis and the possible mechanisms.Methods: Tube formation and matrigel plug angiogenesis assays were used to evaluate angiogenesis in vitro and in vivo, respectively. Real-time PCR, enzyme-linked immunosorbent assay, and Western blot were used to evaluate the mRNA and protein expressions of hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF), and IL-8, respectively. Dual-luciferase reporter assay was applied to assess the reporter gene expression of hypoxia-response element (HRE).Results: UDCA antagonized hypoxic Huh 7 cell-induced tube formation of EA.hy 926 cells. In HCC cells, UDCA inhibited hypoxia-induced upregulation of VEGF and IL-8 both in mRNA and protein levels. UDCA also inhibited IL-8–induced angiogenesis in vitro and in vivo through suppressing IL-8–induced phosphorylation of ERK. The levels of HIF-1α mRNA and protein and HRE-driven luciferase activity in HCC cells were upregulated by hypoxia and were all inhibited by UDCA. The proteasome inhibitor MG132 antagonized the effect of UDCA on HIF-1α degradation. In hypoxic condition, the phosphorylation of ERK and AKT was obviously increased in HCC cells, which was suppressed by UDCA. Transfection of the HIF-1α overexpression plasmid reversed the effects of UDCA on hypoxic HCC cell–induced angiogenesis, HRE activity, and expressions of IL-8 and VEGF.Conclusions: Our results demonstrated that UDCA could inhibit hypoxic HCC cell–induced angiogenesis through suppressing HIF-1α/VEGF/IL-8–mediated intercellular signaling between HCC cells and endothelial cells.

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“…In folkloric practices, plants such as Salvia spp., Zanthoxylum spp., Allium spp., and Zingiber spp. among others are applied in treating many kinds of tumors and cancers [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. Among these plants, species belonging to the genus Salvia appear to stand out due to their reservoir of many chemicals with cytotoxic properties against cancer cells, antimicrobial, anti-inflammatory and antioxidant capabilities [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic benefits of Salvia species: A focus on cancer and viral infection

Ezema

Ezeorba

Aguchem

et al. 2022

Heliyon

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Man is increasingly being faced with many health conditions, including viral infection, some of which increases the risk to cancer. These infectious agents contribute to the large number of persons with cancer and the worrisome number that die from the diseases. A good range of drugs are currently in place for treating patients infected with viruses, however, some of the drugs' effectiveness are limited by the emergence of drug-resistant strains of the viruses, as well as adverse effects of the drugs. Similarly, the inability of many anticancer drugs to selectively kill cancer cells while sparing hosts’ normal cells limit their use. This warrants more research for newer drugs, especially from chemicals naturally encrypted in plants with anticancer and antiviral activities. In response to infection with cancer-inducing viruses, plants such as Salvia species synthesize and store secondary metabolites to protect themselves and kill these viruses as well as inhibit their ability to induce carcinogenesis. Hence, this review presented a discussion on the potential application of Salvia species in the prevention and management of cancer and viral infection. The study also discusses the cellular mechanisms of action of these herbal products against cancer cells and viruses, where available and provided suggestions on future research directions. The study is believed to spur more research on how to exploit Salvia phytochemicals as candidates for the development of nutraceuticals and drugs for managing cancers and viral infection.

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Nigerian antimalarial plants and their anticancer potential: A review

Cited by 25 publications

References 240 publications

Zanthoxylum Species: A Review of Traditional Uses, Phytochemistry and Pharmacology in Relation to Cancer, Infectious Diseases and Sickle Cell Anemia

Zanthoxylum Species: A Review of Traditional Uses, Phytochemistry and Pharmacology in Relation to Cancer, Infectious Diseases and Sickle Cell Anemia

UDCA Inhibits Hypoxic Hepatocellular Carcinoma Cell–Induced Angiogenesis Through Suppressing HIF-1α/VEGF/IL-8 Intercellular Signaling

Therapeutic benefits of Salvia species: A focus on cancer and viral infection

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