Night blindness and conjunctival xerosis caused by vitamin A deficiency in patients with cystic fibrosis.

Corneal Opacity: A Rare Manifestation of Cystic Fibrosis

“…In children, manifestations of vitamin A deficiency include poor skeletal growth, hepatomegaly, increased intracranial pressure, and ocular changes (7). The ocular manifestations of hypovitaminosis A are conjunctival, and corneal xerosis, keratomalacia including ulceration, night-blindness, severe loss of visual acuity, flecked retina, and pseudotumor cerebri (2)(3)(4)(5)(6)(7)(8). Ocular changes in the published literature occur in the adolescent and early adult periods.…”

“…Ocular findings in CF mainly refer to the tear film and are related to tear hyposecretion and improper composition of tears, leading to dry-eye symptoms, considered by some authors as the primary CF eye manifestations (2)(3)(4)(5)(6). Herein, we describe an 11-month-old boy diagnosed as CF with corneal opacity.…”

Bitot's spots following hemicolectomy

“…The authors observed that brimonidine, nevertheless, fails to meet the suggested criteria for establishing causality of adverse events by drugs. 3 These include the reaction being frequently described and well documented. Our case lends additional weight to the evidence for brimonidine causing granulomatous anterior uveitis.…”

“…Vitamin A deficiency has been reported in various gastrointestinal disorders, including Crohn's disease, 2 cystic fibrosis, 3 primary biliary cirrhosis, 4 Jejuno ileal bypass surgery, 5 and hemicolectomy. 6 The clinical manifestations of vitamin A deficiency include night blindness, xerophthalmia, and follicular hyperkeratosis of the skin.…”

Vitamin therapy in cystic fibrosis–a review and rationale

“…However, a more recent study (7) has found that levels are low on supplementation of 5,000 U/day, but can be maintained with 10,000 U/day following 'loading' with a large dose, e.g. 100,000 U/ day.…”