Nighttime Blood Pressure in Normotensive Subjects With Chronic Insomnia: Implications for Cardiovascular Risk

Lanfranchi, Paola; Pennestri, Marie‐Hélène; Fradette, Lorraine; Dumont, Marie; Morin, Charles M.; Montplaisir, Jacques

doi:10.1093/sleep/32.6.760

Cited by 175 publications

(110 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Decreased SWS is associated with a 1.8‐fold increased risk of developing hypertension in elderly men (Fung et al, 2011). The circadian rhythm of BP is blunted in patients with insomnia, even in those who are normotensive (Lanfranchi et al, 2009). Inversely, non‐dippers have poor quality of sleep (Pedulla et al, 1995).…”

Section: Melatonin In the Treatment Of Circadian Rhythm And Sleep Dismentioning

confidence: 99%

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation

Zisapel

2018

British J Pharmacology

573

350

View full text Add to dashboard Cite

In mammals, a central circadian clock, located in the suprachiasmatic nuclei (SCN) of the hypothalamus, tunes the innate circadian physiological rhythms to the ambient 24 h light–dark cycle to invigorate and optimize the internal temporal order. The SCN‐activated, light‐inhibited production of melatonin conveys the message of darkness to the clock and induces night‐state physiological functions, for example, sleep/wake blood pressure and metabolism. Clinically meaningful effects of melatonin treatment have been demonstrated in placebo‐controlled trials in humans, particularly in disorders associated with diminished or misaligned melatonin rhythms, for example, circadian rhythm‐related sleep disorders, jet lag and shift work, insomnia in children with neurodevelopmental disorders, poor (non‐restorative) sleep quality, non‐dipping nocturnal blood pressure (nocturnal hypertension) and Alzheimer's disease (AD). The diminished production of melatonin at the very early stages of AD, the role of melatonin in the restorative value of sleep (perceived sleep quality) and its sleep‐anticipating effects resulting in attenuated activation of certain brain networks are gaining a new perspective as the role of poor sleep quality in the build‐up of β amyloid, particularly in the precuneus, is unravelled. As a result of the recently discovered relationship between circadian clock, sleep and neurodegeneration, new prospects of using melatonin for early intervention, to promote healthy physical and mental ageing, are of prime interest in view of the emerging link to the aetiology of Alzheimer's disease.Linked ArticlesThis article is part of a themed section on Recent Developments in Research of Melatonin and its Potential Therapeutic Applications. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v175.16/issuetoc

show abstract

Section: Melatonin In the Treatment Of Circadian Rhythm And Sleep Dismentioning

confidence: 99%

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation

Zisapel

2018

British J Pharmacology

573

350

View full text Add to dashboard Cite

show abstract

“…Chronic insomnia is associated with elevated nocturnal systolic blood pressure and reduced day-to-night blood pressure dipping [78]. Chronic insomnia is also considered a significant risk factor in the development of mild to moderate hypertension [79,80].…”

Section: Long-term Consequences Of Insomniamentioning

confidence: 99%

Epidemiology of Insomnia

Morin

Jarrin

2013

Sleep Medicine Clinics

Self Cite

196

View full text Add to dashboard Cite

This paper summarizes recent epidemiological evidence on insomnia, including its prevalence, incidence, and risk factors, as well as its course and consequences. There is now substantial evidence that insomnia is a significant public health problem. It is a highly prevalent condition, both as a symptom and a syndrome, and is often a persistent condition over time. Its persistence is associated with increased risk for mental (major depression), physical (hypertension), and occupational health problems (disability). Chronic insomnia also carries heavy economic burden, both in terms of direct healthcare costs and, more importantly, in terms of human resources loss due to the illness and lack of treatment. These findings have direct implications for community-based prevention and intervention programs and for future research including the need for: a) longitudinal, population-based studies aimed at evaluating whether we can prevent insomnia among at-risk individuals; b) clinical studies evaluating whether the morbidity associated with chronic insomnia is reversible; and c) prospective health economic evaluations of prevention programs using different dissemination technologies. Key Points• The epidemiology of insomnia has received increased attention in the last decade and investigators have moved from a purely cross-sectional approach to a more prospective and longitudinal approach.• Progress on the epidemiology of insomnia has been hampered by important methodological shortcomings including, but not limited to, the lack of a consistent case definition and standardized assessment procedures across studies.• Additional prospective and longitudinal studies are needed to identify early precursors of insomnia and factors moderating its trajectories over time.• A better understanding of how insomnia evolves over time and what factors trigger an episode or perpetuate it over time is critical for developing effective prevention and treatment programs. Outline• Introduction • Nature of insomnia complaints and updated diagnostic criteria • Prevalence and correlates of insomnia • Incidence and risk factors • Course of Insomnia -persistence, remission, relapse • Consequences and burden of insomnia

show abstract

“…[8][9][10] Earlier studies have indicated that there is an association between insomnia and hypertension incidence. [11][12][13] In a study in Chinese population, the prevalence of hypertension in those with no insomnia, occasional insomnia and frequent insomnia was reported to be 37.3%, 43.0% and 48.0% respectively.…”

Section: Introductionmentioning

confidence: 99%

A cross-sectional, multi-centric, epidemiology study to determine the prevalence of insomnia and related sleep habits in Indian hypertensive patients

Karnik¹,

Peethambaran²,

Adsule³

2017

Int J Res Med Sci

View full text Add to dashboard Cite

Background: Hypertension is a leading risk factor affecting mortality and disability-adjusted life years worldwide. The objective of the study was to determine the prevalence of insomnia, co-morbid medical conditions, lifestyle attributes, related sleep habits and sleep quality among Indian hypertensive patients.Methods: Adults (≥18 years) with newly diagnosed or known history of hypertension, willing to participate were enrolled in this cross-sectional, epidemiological study. Several variables including lifestyle attributes, sleep habits, quality, medications, demographics, medical/surgical history and other details pertaining to hypertension were analyzed. Insomnia was assessed by Athens Insomnia Scale (AIS) in patients not identified in the past one month.Results: All the 657 enrolled patients completed the study (mean age: 55.4±11.61 years; men: 53.7%; women: 46.3%). Prevalence of insomnia among hypertensive population was approximately 47.2% (n=310; 95% CI: 43.4, 51.0). Number of patients newly diagnosed with insomnia by AIS scale was higher compared with patients already diagnosed with insomnia (34.9% [95% CI: 31.2, 38.5] vs. 12.3% [95% CI: 9.81, 14.8]). Common medical conditions associated with hypertension were diabetes mellitus (61.1%) and dyslipidemia (28.3%). More than half of the hypertensive patients with insomnia had sleep-related problems once or twice a week. Further, the daytime impact of insufficient sleep on wellbeing and functioning was markedly decreased in insomniac patients.Conclusions: Prevalence of insomnia among patients suffering from hypertension was higher than that reported in general Indian population in various studies. Present study shows that about 75% insomniac cases were undiagnosed, indicating that insomnia diagnosis may have been missed in a large proportion of hypertensive patients.

show abstract

Nighttime Blood Pressure in Normotensive Subjects With Chronic Insomnia: Implications for Cardiovascular Risk

Cited by 175 publications

References 37 publications

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation

Epidemiology of Insomnia

A cross-sectional, multi-centric, epidemiology study to determine the prevalence of insomnia and related sleep habits in Indian hypertensive patients

Contact Info

Product

Resources

About