2015
DOI: 10.1038/nature14171
|View full text |Cite
|
Sign up to set email alerts
|

NIK1-mediated translation suppression functions as a plant antiviral immunity mechanism

Abstract: Plants and plant pathogens are subject to continuous co-evolutionary pressure for dominance, and the outcomes of these interactions can substantially impact agriculture and food security1–3. In virus– plant interactions, one of the major mechanisms for plant antiviral immunity relies on RNA silencing, which is often suppressed by co-evolving virus suppressors, thus enhancing viral pathogenicity in susceptible hosts1. In addition, plants use the nucleotide-binding and leucine-rich repeat (NB-LRR) domain-contain… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

6
209
0
2

Year Published

2015
2015
2021
2021

Publication Types

Select...
8

Relationship

2
6

Authors

Journals

citations
Cited by 201 publications
(217 citation statements)
references
References 33 publications
6
209
0
2
Order By: Relevance
“…Total nucleic acids were extracted from systemically infected leaves using a cetyltrimethylammonium bromide (CTAB)-based method (63). Viral DNA accumulation was measured using qPCR as described previously (26). Relative viral DNA accumulation levels were calculated by the comparative threshold cycle (C T ) method (64).…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Total nucleic acids were extracted from systemically infected leaves using a cetyltrimethylammonium bromide (CTAB)-based method (63). Viral DNA accumulation was measured using qPCR as described previously (26). Relative viral DNA accumulation levels were calculated by the comparative threshold cycle (C T ) method (64).…”
Section: Methodsmentioning
confidence: 99%
“…Recently, R gene-mediated resistance has been proposed as another essential defense strategy against geminiviruses. For example, the begomovirus nuclear shuttle protein (NSP)-interacting kinase 1 (NIK1) is able to activate antiviral immunity against cabbage leaf curl virus (CaLCuV) (25,26). Besides the above-mentioned defense mechanisms, host factors such as SNF1-related protein kinase 1 (SnRK1) have also been involved in defense against geminiviruses (27)(28)(29).…”
mentioning
confidence: 99%
“…Another class of receptors, NB-LRRs, counteractively recognize pathogen effector proteins and induce strong defense reactions, called hypersensitive responses; this mechanism is termed effector-triggered immunity (ETI) (50,51). Several NB-LRRs that perceive virus invasion and induce ETI have been identified (52), and recent studies of Arabidopsis RLKs (53,54) suggest the existence of an immune receptor that perceives dsRNAs or other viral factors as viral PAMPs and induces PTI. In animals, Toll-interleukin 1-like receptors (TLRs), which are structurally similar to plant RLKs and NB-LRRs, perceive viral RNA and DNA in endosomes and on cell membranes (55).…”
Section: Discussionmentioning
confidence: 99%
“…In order to gain new insights into the molecular mechanisms of NIK1 in antiviral immunity, arabidopsis transgenic lines harbouring the gain-of-function mutant T474D on a nik1 knockout background were analysed for gene expression (Zorzatto et al, 2015). The constitutive activation of NIK-mediated signalling resulted in the down-regulation of translation-related genes and the suppression of global translation, decreasing the loading of host mRNAs in actively translating polysomes (Zorzatto et al, 2015).…”
Section: Downstream Components Of the Nik-mediated Antiviral Responsementioning
confidence: 99%
“…Plants have also been found to use innate pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) to limit viral infection (Kørner et al, 2013). More recently, a transmembrane immune receptor, which is structurally similar to co-receptor-like kinases involved in PTI, has been shown to activate host translation suppression to fight DNA viruses, a newly discovered mechanism for antiviral defences in plants (Zorzatto et al, 2015). Viral infections can also lead to hormonal disruption, which manifests as simultaneous induction of many antagonistic hormones and triggering of defence responses (Alazem and Lin, 2015).…”
Section: Introductionmentioning
confidence: 99%